Molecular Biology of the Cell by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter by by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morg

Index I:11
polytene chromosomes 208–211
rRNA genes 181F, 330
chromosomes, homologous see homologs
chromosomes, numbered human see
human chromosome
chronic myelogenous leukemia (CML)
1093–1095, 1135–1136
chymotrypsin, compared with elastase
119F
Ci (Cubitus interruptus) transcription
regulator 871–873
CICR (Ca 2+ -induced calcium release) 838
cilia
built from microtubules 941–942
microtubules and 890–891
olfactory receptors 843, 844F
planar cell polarity and 1189
primary cilia 824F, 845F, 873
stereocilia 890, 892, 924, 1189
see also axonemes
ciliary dyneins (axonemal dyneins)
937–938, 942
circadian clocks 876–879, 1183
circular DNA
conservative site-specific
recombination 293F
in mitochondria 804
in prokaryotes 23F
replication 242F, 255F
circumferential belts 924
cis-acting lncRNAs 435F, 436
cis-double bonds, in phospholipid tails
566, 571
cis-Golgi network (CGN) 716
cis-regulatory sequences 402, 406–407,
409
CRE as 836
as enhancers 386
Eve gene 393, 395
in gene control regions 384–385
and genome annotation 477
immunoglobulin chains 1320
insulators and 391
master regulators and 399–401
nucleosomes and 379–380
occupation by transcription regulators
505
reporter genes and 501
as sequence logos 375, 378F
transcription regulator recognition
and binding 373–375, 379–381,
383–384
cisternae, Golgi apparatus 642, 715–716
cisternae, rough ER 671F
cisternal maturation model 720–721
cisternal space 669
citrate synthase 106
citric acid cycle
excess citrate from 760
macromolecule precursors from 85F
mitochondria and 664, 758–759
overview 106–107
in plants 786
CK1 (casein kinase 1) 870
CKIs (Cdk inhibitor proteins) 970–971,
972F, 973T, 1003–1004,
1013–1014, 1015F
Cl – (chloride ion) channels 612–613, 629
clamp loader complex 247–249
class switch recombination 1323
class switching, B lymphocytes 1320,
1322–1323, 1335–1336, 1338F
classical cadherins 1037T, 1038,
1039–1040F, 1042
classical pathway, complement system
1302–1303, 1318T
clathrin-coated pits, plasma-membrane
553F, 731, 734, 1280
clathrin coated vesicles
adaptor proteins 698–699
assembly 697–698, 700F, 703, 727
coat structure 699F
protein delivery to 736, 853
claudins 1048–1051
cleavage furrows 996–1000
clonal analysis 1221F, 1222
clonal deletion
absence of co-stimulation 1337
immunological self-tolerance
1313–1314, 1321
negative selection 1332
clonal expansion 808, 1309–1311
clonal inactivation/clonal suppression
immunological self-tolerance 1314
clones
the body as a clone of the egg 1091
mutant, and cancers 1091–1094,
1097F
subclones in cancer 1096, 1097F,
1118–1119, 1123
Clostridium difficile 1264
cloverleaf structures 335–336
CLRs (C-type lectin receptors) 1300
cluster analysis approach 504
CMC (critical micelle concentration) 583,
584F
CNS see central nervous system
CNVs (copy number variations) 232, 492
co-immunoprecipitation 457, 505, 506F
co-repressors 385, 386F, 390, 392, 394,
395F
co-stimulatory proteins/signals
B7 proteins 1337–1338
dendritic cell expression 1305, 1306F,
1314, 1326, 1327F, 1337, 1338F
helper T cells 1314, 1335
naïve lymphocyte response
1310–1311F, 1316F, 1332
co-translational processes
contrasted with post-translational
670, 678F
protein import into ER 670, 674
size limits 744
co-transporters see symporters
coactivators 385–386, 388–389, 392,
394, 395F
coat-recruitment GTPases 703
coated vesicles
coat assembly switching, Golgi
apparatus 713
three types 697
coatomer 713
“coccus” ending 1267
Cockayne syndrome 271
codon-anticodon matches 345, 804
codon bias 482
codons (nucleic acids)
amino acid equivalents 7, 334
mitochondrial usage 804–805
stop and start codons 347–349
synonymous codons 219–220
coenzyme A 68–69
see also acetyl CoA
coenzyme Q (ubiquinone) 765–766, 767F,
768–770, 771F, 772–773
coenzymes
nucleotides as 101
and vitamins 146–148
see also activated carriers
cofactors, electron-carrying 764
cofilin (actin depolymerizing factor) 905,
910, 914, 954, 957, 958F
cohesins 215, 550, 977–979, 982, 992,
993F, 1004, 1007–1008F, 1009.
coiled coils
cytoskeletal filaments 915F, 931F,
936, 937–938F, 945, 950F
derived from α-helices 116–117, 124,
137
in intermediate filaments 894,
945–946, 950F
in kinesin tails 936
leucine zipper motif 376
in myosin II 915
see also DNA supercoiling
coincidence detectors 699, 733, 825
colchicine 459, 904T, 929, 935, 939, 993
collaboration, in multicellular organisms
1091
collagen
assembly 130
triple helix 124–125, 1061–1062
Type IV collagen 1058F, 1062,
1069–1073
Type XVII collagen 1037T, 1062, 1070,
1076F
vesicular transport of procollagen 704
collagen family proteins
as extracelluar matrix macromolecules
1057, 1061–1064
fibril-associated collagens 1062–1064
fibrillar collagens 1058F, 1062–1064
nonfibrillar collagens 1063T
and their properties 1063T
collagen fibers 1058, 1062, 1064
collagen fibrils 1057F, 1058, 1060,
1062–1065, 1069F
color blindness 300F
colorectal cancers
common genetic abnormalities
1123–1124
driver mutations 1112F, 1117
epigenetic changes 1110F
evidence on stem cells from 1220
tumor progression example
1122–1125
combination therapies, for cancer and
AIDS 1139–1140
combinatorial controls
Eve gene 394–395
gene expression and cell type
396–398, 399, 1150, 1160
logic functions governing 430
miRNAs 430
of transcription regulators 396, 397F,
399, 520–521
combinatorial diversification 1320
combinatorial regulatory codes 166
commensalism 1264, 1277, 1298
commissural neurons 1202–1204
committed precursors see transit
amplifying cells
committed progenitor cells
fate of 1245–1246
Page numbers with an F refer to a figure; page numbers with a T refer to a table.