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Molecular Biology of the Cell by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter by by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morg

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888 Chapter 15: Cell Signaling

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fluorescent reporters uncover signaling dynamics in living biological

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proteins come together and when they’re apart. Science 326,

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modifications with interaction domains. Nat. Rev. Mol. Cell Biol.

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blinkers: dynamics of regulatory and signaling pathways in the cell.

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phosphorylation. Nat. Rev. Mol. Cell Biol. 8, 530–541.

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G domain, a canonical switch motif. Annu. Rev. Biochem.

80, 943–971.

Signaling Through G-protein-coupled Receptors

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activation. Cell 151, 14–23.

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of cAMP generation in mammalian cells: a tale of two systems.

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complexes: getting to the heart of the matter. Trends Mol. Med.

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signaling and drug development. N. Engl. J. Med. 355, 2003–2011.

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Robishaw JD & Berlot CH (2004) Translating G protein subunit diversity

into functional specificity. Curr. Opin. Cell Biol. 16, 206–209.

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and function of G-protein-coupled receptors. Nature 459, 356–363.

Shenoy SK & Lefkowitz RJ (2011) beta-Arrestin-mediated receptor

trafficking and signal transduction. Trends Pharmacol. Sci.

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intertwining molecular networks. Nat. Rev. Mol. Cell Biol.

10, 609–622.

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studies on the regulation of Ca 2+ /calmodulin dependent protein

kinase II. Curr. Opin. Struct. Biol. 23, 292–301.

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dynamics. Nat. Methods 5, 29–36.

Signaling Through Enzyme-coupled Receptors

Jura N, Zhang X, Endres NF et al. (2011) Catalytic control in the

EGF receptor and its connection to general kinase regulatory

mechanisms. Mol. Cell 42, 9–22.

Lemmon MA & Schlessinger J (2010) Cell signaling by receptor tyrosine

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13, 616–630.

Manning BD & Cantley LC (2007) AKT/PKB signaling: navigating

downstream. Cell 129, 1261–1274.

Mitin N, Rossman KL & Der CJ (2005) Signaling interplay in Ras

superfamily function. Curr. Biol. 15, R563–R574.

Pitulescu ME & Adams RH (2010) Eph/ephrin molecules—a hub for

signaling and endocytosis. Genes Dev. 24, 2480–2492.

Qi M & Elion EA (2005) MAP kinase pathways. J. Cell Sci.

118, 3569–3572.

Rawlings JS, Rosler KM & Harrison DA (2004) The JAK/STAT signaling

pathway. J. Cell Sci. 117, 1281–1283.

Roskoski R, Jr (2004) Src protein-tyrosine kinase structure and

regulation. Biochem. Biophys. Res. Commun. 324, 1155–1164.

Schwartz MA & Madhani HD (2004) Principles of MAP kinase signaling

specificity in Saccharomyces cerevisiae. Annu. Rev. Genet.

38, 725–748.

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integration to cancer, diabetes and ageing. Nat. Rev. Mol. Cell Biol.

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Alternative Signaling Routes in Gene Regulation

Bray SJ (2006) Notch signalling: a simple pathway becomes complex.

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signalling and its roles in development and disease. Nat. Rev. Mol.

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Huang P, Chandra V & Rastinejad F (2010) Structural overview of

the nuclear receptor superfamily: insights into physiology and

therapeutics. Annu. Rev. Physiol. 72, 247–272.

Markson JS & O’Shea EK (2009) The molecular clockwork of a proteinbased

circadian oscillator. FEBS Lett. 583, 3938–3947.

Mohawk JA, Green CB & Takahashi JS (2012) Central and peripheral

circadian clocks in mammals. Annu. Rev. Neurosci. 35, 445–462.

Niehrs C (2012) The complex world of WNT receptor signalling.

Nat. Rev. Mol. Cell Biol. 13, 767–779.

Signaling in Plants

Chen M, Chory J & Fankhauser C (2004) Light signal transduction in

higher plants. Annu. Rev. Genet. 38, 87–117.

Dievart A & Clark SE (2004) LRR-containing receptors regulating plant

development and defense. Development 131, 251–261.

Kim TW & Wang ZY (2010) Brassinosteroid signal transduction from

receptor kinases to transcription factors. Annu. Rev. Plant Biol.

61, 681–704.

Mockaitis K & Estelle M (2008) Auxin receptors and plant development:

a new signaling paradigm. Annu. Rev. Cell Dev. Biol. 24, 55–80.

Stepanova AN & Alonso JM (2009) Ethylene signaling and response:

where different regulatory modules meet. Curr. Opin. Plant Biol.

12, 548–555.

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