Molecular Biology of the Cell by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter by by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morg

I:8 Index
speed of protein and ribozyme 363
catalytic cascades (enzyme cascades)
848, 873, 881
catastrophe, microtubules 927–928,
932–935, 986
catastrophe factors 934–935, 986
catenins
as adaptor proteins 1042
α-catenin 1042–1043, 1044F
β-catenin 868–871, 1037T, 1042,
1045, 1124
p120-catenin 1042, 1046F
γ-catenin (plakoglobin) 1037T, 1042,
1046F
Caulobacter crescentus 897, 898F
caveolae
in endocytosis 572
as pinocytic vesicles 731–732
TGFβ inactivation 866
CBC (cap-binding complex) 317, 323F,
325, 327F
CBP (CREB-binding protein) 836
CCR5 receptor 1279
CD4 co-receptors 1330T, 1331–1333,
1335–1338
CD4 receptor 1279
CD8 co-receptors 1330T, 1331–1333,
1335–1336, 1337F, 1338
CD31 protein 1312
CD40 receptors 1337
Cdc2 protein (now Cdk1) 463F, 969T
Cdc3 protein 950F
Cdc6 protein 975, 976F
Cdc12 protein 950F
Cdc14 phosphatase 995
Cdc20 protein 971, 972F, 973, 993–994,
1003
Cdc25 phosphatase 970, 973T, 979, 1014
Cdc28 protein (now Cdk1) 969T
Cdc42, as Rho family member 854T, 858,
956–957
Cdh1 protein 971, 973T, 1003–1004,
1013–1014
Cdks (cyclin-dependent kinases)
and cyclins in vertebrates and yeast
969T
inactivation 1002, 1116
role in cell cycle control system 968
cDNA (complementary DNA)
cloning 470–471
DNA microarrays and 503, 504F
RNA sequencing using 477, 503–504
CDP-choline (cytidine-diphosphocholine)
689F
Cdt1 protein 975, 976F
cell adhesion
at cell-matrix junctions 1074
cell-substratum adhesion 954–955,
956F
loss of, in apoptosis 1023
protein CD31 1312
see also cell-cell adhesion
cell cannibalism 1248
cell-cell adhesion
β-catenin and 870
in the bloodstream 1054–1055
control of 582–583, 870
desmosomes in 946
embryonic cell sorting 1187–1188
immunoglobulins in 1055–1056
T cell binding 1325–1326
tissue remodeling 1043–1045
vertebrate embryo patterning 1178
cell-cell contact
contact-dependent signaling 815F
desmosomes 946
hematopoietic stem cells 1244
immunological synapses 1344F
lateral inhibition dependent on 1152,
1173F
Rac and Rho in actin organization at
957, 958F
signaling dependent on 1150
cell-cell junctions
anchoring junctions 1036, 1037T
cadherin mediation 1037F, 1188
focal adhesions 863
intermediate filaments 891
major forms 1038–1056
microtubules 931–932
planar cell polarity 1190
repulsive interactions 1188, 1206
see also cell-matrix junctions; gap
junctions; tight junctions
cell coats 582, 583F
cell cortex
actin filaments beneath 592, 891, 907
cortical cytoskeleton 591–593
in mitosis 913
cell cycle
accessory proteins and 895
Caenorhabditis elegans 33
changes in the nucleolus 330F
eukaryotic 185, 258F, 964–966
homologous recombination use 275
length and cell type 1012
M and S phase 963
mitosis 978–995
model organisms 966
overview 963–967
permanent arrest 1016
regulatory transitions 967
response to DNA damage 276,
1014–1015
Saccharomyces cerevisiae 31–32
subnuclear structures and 331
suggested timekeeping role 1180
temperature-sensitive mutations and
489
withdrawal of sympathetic neurons
1018
see also cell division
cell-cycle control system
overview 967–974
regulatory proteins 973T, 1108, 1115
resetting 975, 1003
transcriptional regulation in 971
cell-cycle network, feedback 516
cell death, programmed
apoptosis and necroptosis 1021
contrasted with necrosis 1021, 1022F,
1099, 1115–1116
see also apoptosis
cell determination 1148
cell division
asymmetric 1001–1002, 1153,
1173–1174, 1222
control of cell growth and 1010–1018
cytoskeleton in 890, 892F
Lgr5 cell cycle times 1221
limits, for human cells 1016,
1099–1100
mitogens in 1011–1012
rate in hematopoietic stem cells 1243
see also meiosis; mitosis
the cell doctrine 529
cell fate determinants 1002, 1243F, 1246
cell-free cloning 474
cell-free systems 451, 673, 1224F
cell fusion prevention, by membrane lipids
570
cell growth
control and the PI-3-kinase-Akt
pathway 861
control of, in plants 1085
control of cell division and 1010–1018
distinguished from cell proliferation
1011
key regulatory pathways 1113–1114
see also growth factors
cell lines
eukaryotic 442–444
mouse fibroblast 1106
RNA interference 499
cell mass regulation 1194–1196
cell-matrix junctions
actin-linked 1036
anchoring junctions 1037T
epithelial tissue 1035–1036
integrin mediation 1037F, 1079
response to mechanical forces
1080–1081
transmembrane receptors 1074–1081
cell membranes
composition 571T
proportion of protein 576
three classes of lipids 566–568
see also plasma membranes
cell memory
and chromatin structure 194, 197,
206, 387
and differentiation 392, 397F, 401–402
in embryonic development 1148,
1150, 1162, 1164
Hox complexes and 1164
intracellular signaling pathways 825,
829, 843F
overriding with cell reprogramming
1251
and positive feedback 520, 829
reinforcement mechanisms 404–413
see also epigenetic inheritance
cell migration
cell sorting in 1188
chemotaxis and 958–960
cytoskeletal coordination in 959–960
endothelial cells 1235
environmental cues 1185–1186
neurons 1200, 1201F
polarization and 951–960
survival factors and 1186–1187
three components 951
cell numbers
body size correlation with 1193
regulation as cell mass 1194–1196
cell plates 1000–1001, 1082
cell polarization 748–750
in epithelia 749, 1047
microtubules 927, 940F
and migration 951–960
planar cell polarity 1189–1190
and Rho family proteins 955–959
role of the cytoskeleton 892–893