Molecular Biology of the Cell by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter by by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morg

I:34 Index
myoepithelial cells 1232, 1233F
myofibrils 918–921
myosin
access to actin bundles 912
actin and, in muscle contraction
916–920
in actin arrowheads 898
ATP hydrolysis by 916
in cell migration 954–955
in the contractile ring 890
fusion with GFP 548F
as a motor protein 162
in non-muscle cells 923–925
myosin gene mutations 923
myosin protein superfamily 924–925
myosin I 924
myosin II 911, 915–918, 923–924, 936,
948, 953, 955–957
adherens junction links 1042, 1044
in cell motility 955–957
light and heavy chains 915, 922–923,
923F, 957, 958F
myosin XIV 924F, 1282
myostatin 1196–1197
myotendinous junctions 1075, 1076T
myotonia 627
myotonic dystrophy 324
myristic acid 578
N
N-formylated peptides 958
N-linked oligosaccharides 683–684,
685–686, 716–720
complex and high-mannose 717
N-terminal histone tails see histone tails
N-termini
acetylation and degradation 360–361
anchoring Src kinases 155
cadherin linking 1040F
polypeptide backbone 110F
pro-peptides, protein precursors 744
signal sequences at 647, 663, 679
Na + -Ca 2+ exchanger 607
Na + -driven Cl – -HCO 3 -exchanger 604
Na + gradient 602, 603F, 604, 605F, 608,
616
Na + -H + antiporters 781
Na + -independent Cl – -HCO 3
–
exchanger
604–605
Na + -K + pump proteins 585F, 607–608.
615
Na + -linked symporters 603, 604F, 605,
632
NAD + (nicotinamide adenine dinucleotide)
as an electron carrier 754
regeneration 760
NADH dehydrogenase complex
(Complex I) 767–770, 769F
NADH (reduced nicotinamide adenine
dinucleotide)
as an activated carrier 64
as an electron donor 67–68, 764
in catabolic reactions 68, 74
production by glycolysis 74–78
production in the citric acid cycle
82–84, 759
respiratory-chain complexes and
766–768
NADPH oxidase complex 1301
NADPH (reduced nicotinamide adenine
dinucleotide phosphate)
as an activated carrier 64
as an electron carrier 67–68, 760
in anabolic reactions 68
in photosynthesis 755, 784
as a reducing agent 68F
naïve B and T cells
co-stimulatory signal requirement
1314
locating APCs 1311
in lymphocyte differentiation 1310
naïve B cells 1316–1317, 1322
naïve T cells 1314, 1326, 1328,
1332–1333, 1335–1337, 1338F
NANA (N-acetylneuraminic acid) 575F,
717F
nanodiscs 586
Nanog gene 1254F
Nanog protein 378F, 506F
nanomachines see protein machines
nanoparticles
immunogold electron microscopy 557
quantum dots as 538
Nanos protein 1158F
natural killer (NK) cells 1240, 1241T, 1304,
1333–1334
natural selection
mutation and 15–16
and pathogens 1289
protein structure and 119–120
purifying selection 219–220, 221F,
223, 225, 231
small selective advantages 226
and tumor progression 1091–1092,
1096, 1104, 1118, 1119F, 1125
NCAMs (neural cell adhesion molecules)
1055–1056, 1338F
Ndc80 complex 987, 988F, 990F, 991
Neanderthals 220, 223–224, 232F, 300F,
479
nebulin 919, 920F
necroptosis 1021
necrosis
contrasted with programmed cell
death 1021, 1022F
as typical of cancer cells 1099, 1110F,
1116
negative feedback
Cdc20-APC/C 993
in cell regulation 515–516
in cell signaling 829–830, 853
circadian clocks and 876–878
delayed negative feedback 516, 517F,
1179F
Hedgehog pathway 873
Hes and Her genes 1178, 1179F
JAK-STAT signaling pathway 863
NFκB pathway 874, 875F
rate constant fluctuations 516F
Smad signaling pathway 866
Wnt signaling pathway 871
negative feedback loops 402
common to all cells 402
rod cells 845
negative regulation of enzymes 151, 152F
negative selection 1332, 1333F
negative staining 559–561
Neisseria gonorrhoeae
antibiotic resistance 19
protection against the complement
system 1303
Neisseria meningitidis 1291
Neisseria spp.
phase variation 1290
nematodes see Ascaris; Caenorhabditis
elegans
neoblasts 1248–1249
neoplasms, defined 1092
see also cancers; tumors
Nernst equation 615–616
nerve cells see neurons
nerve impulses see action potentials
nerve terminals 1209
nesprins (KASH proteins) 949, 959
netrins 1202–1204
network motifs 402
see also feedback
neural crest cells 951, 959, 1041–1042,
1076T, 1186
neural development 1198–1213
four phases 1199F
vertebrates 1199–1200
neural map formation 1204–1206
neural stem cells 1201F, 1250–1251
neural tube 1040F, 1041, 1045F, 1186,
1192, 1199
neuraminic acid, N-acetyl- (NANA) 575F
neurites 940, 1202
neuroblasts 1173–1174, 1179–1180, 1200
neurodegenerative diseases
amyloid fibrils in 130–131
neurofilaments in 947
plectin gene mutations and 949
stem cell potential 1250–1251
neurofilament proteins (NF-L, NF-M and
NF-H) 944T, 947
neurogenesis, in Drosophila 1173–1174
neurogenic ectoderm 1166, 1173–1174,
1179, 1186
neurological diseases 939
neuromuscular junctions
acetylcholine receptors 630–631
regeneration 1071–1072
synapse formation 1209, 1210F, 1211
neuromuscular transmission and ion
channels 632–633
neuronal doctrine 441
neuronal migration 913F
neuronal specificity 1205
neurons
absence of energy storage 87
activity-dependent synaptic change
1211–1212
basket cell 1198F
commissural neurons 1202–1204
computation by single neurons
633–636
as examples of long-distance
signaling 815
firing rate 623, 635
firing rule 1212
fluorescence microscopy 543F
growth cone 858, 943, 951
intermediate filaments 947, 948F
lateral inhibition 867, 868F
liver cell conversion to 396, 397F
microtubule-associated proteins 932,
940F
migration 1200, 1201F
myelin sheathing 625
neurotrophic factors and 1208–1209
normal neuronal death 1208
olfactory receptor 844F