Molecular Biology of the Cell by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter by by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morg

I:14 Index
RAB proteins on 705
cytotoxic T lymphocytes 611
CD8 expression 1331–1332
class I MHC presentation 1326,
1329F, 1330T
dendritic cell activation 1329, 1333,
1335
foreign protein recognition 1327F,
1328
killing target cells 1333–1334
NK cells resembling 1304–1305, 1333
as a T cell class 1325
D
D gene segments 1320
D-V (dorsoventral) axis
animal body plan 1147
cortical rotation, Xenopus 1167
Dorsal transcription regulator and
1164–1165, 1166F
nervous system development 1199,
1200F
polarization of the embryo 1155–1158
retinotopic map 1206
vertebrate equivalent 1169
Dally and Dally-like proteoglycans 1073
Danio rerio see zebrafish
DAPI dye 537–538F, 800F
dark-field microscopes 533–534, 535F
databases, protein
mass spectrometry matching
456–457
and protein structure prediction 462
DDK kinase 975, 976F
ddNTP (dideoxy nucleoside triphosphates)
478
de-differentiation 398, 1249
de novo methyl transferases 404–405,
406F
de novo mutations 494
deamination
of 5-methlycytosine 405
adenine to inosine 335, 336–337F,
418
arginine to NO 847
cytosine to uracil 267T, 268, 269F,
272F, 418, 1322–1323
of DNA yielding unnatural bases
271–273
RNA editing 418–419
death receptors 1024–1025
decapping mRNA 426–428
decorin 1058F, 1060
default secretory pathway 741
defensins 1298, 1302
degenerative disease treatment
1258–1259
degradation complex 870
degrons 158
degrowth 1248
dehydrogenation and hydrogenation 56
Deinococcus radiodurans 483
delayed K + channels 634–635
delayed negative feedback 516, 517F
delayed response genes 1013F
deletion mutations 487
Delta protein 867, 868F, 1172, 1173F,
1178–1179, 1224
denaturing of DNA 472
denaturing of proteins 114, 453, 584
dendrites
in neural development 1198, 1199F,
1200–1201, 1206–1207, 1208F
role in neurons 621, 940
self-avoidance 1206–1207
dendritic cells
antigen processing 1330F
co-stimulatory protein expression
1306F, 1314, 1326, 1337, 1338F
cytotoxic T cells and 1333, 1335
derived from monocytes 1240, 1243F
Langerhans cells as 1226F, 1240
linking innate and adaptive immune
systems 1305, 1306F
negative selection in thymocytes
1332
as professional APCs 1307, 1328
role as antigen peptide presenters
1240, 1305
surface proteins displayed 1306F,
1326, 1327F, 1330
T cell binding and activation
1324–1326, 1331
use of cross-presentation against
viruses and tumors 1329
dense-core secretory granules see
secretory vesicles
deoxyribose
stability conferred by 366
structure 100
dephosphorylation, M-Cdk and 970–971,
978, 993–995, 998
depth of field 533F, 558–559
depurination 267T, 268–269, 270F
dermatan sulfate 1058
desensitization see adaptation
desmin 944T, 948–949, 1046
desmocollins 1037T, 1038, 1039F, 1046F
desmogleins 1037T, 1038, 1039F, 1046F
desmoplakin 1037T, 1046F
desmosomes 893F, 946, 1036, 1226F
desmotubules 1053, 1054F
detergent solubilization, membrane
proteins 583–586, 766
deterministic models 524
detoxification
carcinogen activation and 1128
of oxygen 796
by peroxisomes 667
in smooth ER 670
developing tissues see embryonic
development
developmental complexity and gene
repression 390
diabetes
β-cell renewal and 1226
insulin levels and cancer risk 1115
as a multigenic condition 493
Type I as an autoimmune diseases
1315, 1332–1333
diacylglycerol 819, 837, 838F, 859, 862F
Diap gene 1197F
Dicer enzyme 430F, 431–433
Dictyostelium 559F, 958
dideoxy sequencing 466F, 477–478
Didinium 25F
differential equations
coupled differential equations 515
and deterministic models 524
for positive feedback 518
protein concentrations and 513–514
and transient behavior 512–513
differential-interference-contrast
microscopes 533–535, 560F,
1002F
differentiation
from the blastomere 1148F
embryoid bodies from iPSs 1257F
epigenetic inheritance and 205
four general statements 371
genetic mechanisms maintaining
392–404
reprogramming cell types 396, 398
retention in culture 441–442
stepwise commitment in
hematopoiesis 1243–1244
terminally differentiated cells 400,
816, 1012, 1121
transcription regulator activation
1170–1171
variations in cancer cells 1121, 1122
without changes in the genome 369
diffraction effects, in microscopy 531,
539F
diffraction limit to resolution 532, 549,
551, 554
diffusion
within lipid layers 569–570, 601
passive diffusion into nuclei 650
and reaction rates 59–60
and signal molecule gradients
1151–1153, 1158F, 1166
of small molecules across membranes
598
diffusion coefficients 570, 589
diffusion-limited reaction rates 143, 148
digestion, enzymatic 74
digital cameras in microscopy 555
digital image enhancement 534
digoxigenin 467
dihydroxyacetone 96
dihydroxyacetone phosphate 104
dilated cardiomyopathy 923
dilution effects 513–514
dimerization/dimers
α- and β-tubulin 925
ATP synthases 778, 779F
caspases 1023–1025, 1026F
fibronectin 1067
helix-loop-helix proteins 377
integrins 1075
of MHC proteins 1327
polypeptide 123
of RTKs on ligand binding 851
single-pass transmembrane proteins
580
T cell receptors 1325
TGFβ superfamily 865
transcription regulators 375–378
tyrosine-kinase-associated receptors
862
dimorphism, pathogenic fungi 1271–1272
diplotene 207F, 1006, 1007F, 1010
DISC (death-inducing signaling complex)
1024–1025
discontinuous responses 827, 829
see also switches
diseases
analysis using stem cells 1258–1259
linked to DNA repair 266T
linked to integrin defects 1076–1077
linked to mitochondrial mutations
807–808