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Molecular Biology of the Cell by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter by by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morg

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MBoC6 n6.100/6.01

300 Chapter 6: How Cells Read the Genome: From DNA to Protein

human X chromosome: 155 million nucleotide base pairs (~5% of genome)

total length of this section = 1.25 million nucleotide pairs

Mir718

Mecp2

Opn1lw

Tex28

Opn1mw

Tex28

Opn1mw

Tex28

Tktl1

Flna

Emd

Colorblindness

Rpl10

Dnase1l1

Taz

Atp6ap1

Gdi1

Fam50a

Plxna3

Lage3

Ubl4a

Slc10a3

Fam3a

G6pd

Ikbkg

Fam223b

Ctag1b

Ctag1b

Fam223b

Ikbkg

Ctag2

Gab3

Abcd1

Plxnb3

Srpk3

Idh3g

Ssr4

Pdzd4

L1cam

Avpr2

Arhgap4

Naa10

Renbp

Hcfc1

Tmem187

Irak1

DNA

Adrenoleukodystrophy

Mir3202

conservation

100

0

Snora70

Incontinentia Pigmenti

Dkc1

Mpp1

Smim9

F8

Mir1184-3

Snora36a

Snora56

Hemophilia A

KEY:

intron

exon

100

intergenic region

non-synonymous

difference in

Neanderthal sequence

microRNA or

snoRNA

Incontinentia Pigmenti

disease phenotype caused by

nucleotide changes in the

indicated gene

0

conservation across species

(alignments of 100 vertebrate genomes)

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