Molecular Biology of the Cell by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter by by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morg

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Julian Hart LewisAugust 12, 1946—April 30, 2014
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Page 2: THE CELLMolecular Biology ofSixth E
Page 5: Garland ScienceVice President: Deni
Page 9 and 10: viiiPREFACEcase, we now provide the
Page 11 and 12: xNOTE TO THE READERMoreover, there
Page 13 and 14: xiiNOTE TO THE READERshort answer,
Page 15 and 16: xivACKNOWLEDGMENTSFrancisco), Berti
Page 17 and 18: xviACKNOWLEDGMENTSUniversity), Doug
Page 19 and 20: xviiiACKNOWLEDGMENTSChapel Hill), A
Page 21 and 22: xxSpecial FeaturesTable 1-2 Some Mo
Page 23 and 24: xxiiDETAILED CONTENTSGlycolysis Ill
Page 25 and 26: xxivDETAILED CONTENTSConservative S
Page 27 and 28: xxviDETAILED CONTENTSThe Bacterial
Page 29 and 30: xxviiiDETAILED CONTENTSMembrane-Ben
Page 31 and 32: xxxDETAILED CONTENTSAccessory Prote
Page 33 and 34: xxxiiDETAILED CONTENTSCancer Cells
Page 35 and 36: xxxivDETAILED CONTENTSCells of One
Page 37 and 38: 2 Chapter 1: Cells and Genomes(A)10
Page 39 and 40: 4 Chapter 1: Cells and Genomestempl
Page 41 and 42: 6 Chapter 1: Cells and Genomespolys
Page 43 and 44: 8 Chapter 1: Cells and GenomesLife
Page 45 and 46: 10 Chapter 1: Cells and GenomesSumm
Page 47 and 48: 12 Chapter 1: Cells and Genomesgeoc
Page 49 and 50: 14 Chapter 1: Cells and GenomesHSV1
Page 51 and 52: 16 Chapter 1: Cells and GenomesGTTC
Page 53 and 54: 18 Chapter 1: Cells and Genomes764
Page 55 and 56: 20 Chapter 1: Cells and Genomestran
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22 Chapter 1: Cells and Genomespart
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24 Chapter 1: Cells and Genomesthis
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26 Chapter 1: Cells and Genomes(B)(
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28 Chapter 1: Cells and Genomesearl
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30 Chapter 1: Cells and GenomesFigu
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36 Chapter 1: Cells and Genomeshour
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38 Chapter 1: Cells and GenomesWe A
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40 Chapter 1: Cells and Genomes1-5
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43Cell Chemistry andBioenergeticsch
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THE CHEMICAL COMPONENTS OF A CELL45
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MBoC6 e3.03/2.12CATALYSIS AND THE U
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CATALYSIS AND THE USE OF ENERGY BY
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MBoC6 m2.51/2.29CATALYSIS AND THE U
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HOW CELLS OBTAIN ENERGY FROM FOOD73
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CHAPTER 2 END-OF-CHAPTER PROBLEMS89
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91phosphoric acid, H 3 PO 4 . It is
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93WATER AS A SOLVENTMany substances
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Na + +95HYDROPHOBIC FORCESHHCHHCHHW
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97α AND β LINKSThe hydroxyl group
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99LIPID AGGREGATESFatty acids have
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101NOMENCLATURE A nucleoside or nuc
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103THE ENTROPY, SThe second law (bu
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105Step 6 The two moleculesof glyce
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107Step 3 In the first offour oxida
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109Proteinschapter3When we look at
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THE SHAPE AND STRUCTURE OF PROTEINS
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ACIDIC SIDE CHAINSaspartic acid(Asp
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PROTEIN FUNCTION133soluble protein
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PROTEIN FUNCTION135ligandbindingsit
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PROTEIN FUNCTION137polypeptide liga
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PROTEIN FUNCTION139B BAAthe surface
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PROTEIN FUNCTION141rate of reaction
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143THE DOUBLE-RECIPROCAL PLOTA typi
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PROTEIN FUNCTION145SLOW(A)NHHOCOHHC
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PROTEIN FUNCTION147Table 3-2 Many V
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PROTEIN FUNCTION149FATTY ACID SYNTH
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PROTEIN FUNCTION151Feedback inhibit
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PROTEIN FUNCTION153percent enzyme a
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PROTEIN FUNCTION155tyrosinekinasesu
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PROTEIN FUNCTION157Figure 3-65 How
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PROTEIN FUNCTION159NLys63ubiquitinM
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PROTEIN FUNCTION161NH 2GTPswitch he
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PROTEIN FUNCTION163which walks alon
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PROTEIN FUNCTION165unstructuredregi
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PROTEIN FUNCTION167We can gain some
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SUMMARY169can we hope to understand
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IPARTIIIII IV VBasic Genetic Mechan
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THE STRUCTURE AND FUNCTION OF DNA17
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THE STRUCTURE AND FUNCTION OF DNA17
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CHROMOSOMAL DNA AND ITS PACKAGING I
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CHROMATIN STRUCTURE AND FUNCTION195
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THE GLOBAL STRUCTURE OF CHROMOSOMES
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HOW GENOMES EVOlvE217nucleotide seq
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HOW GENOMES EVOlvE219millions of ye
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HOW GENOMES EVOlvE221ancestorarmadi
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HOW GENOMES EVOLVE223human β-globi
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HOW GENOMES EVOLVE225blocks from ma
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HOW GENOMES EVOlvE227Mutations in t
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HOW GENOMES EVOLVE229Figure 4-75 A
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HOW GENOMES EVOlvE231compared. For
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HOW GENOMES EVOLVE233density ofknow
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237DNA Replication, Repair,and Reco
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DNA REPLICATION MECHANISMS239gamete
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DNA REPLICATION MECHANISMS2415′ t
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DNA REPLICATION MECHANISMS2433′5
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DNA REPLICATION MECHANISMS245Figure
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DNA REPLICATION MECHANISMS249The Pr
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DNA REPLICATION MECHANISMS251error
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THE INITIATION AND COMPLETION OF DN
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DNA REPAIR267OOHNH 2 NGNO CH 2OP O
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DNA REPAIR269Figure 5-39 The most c
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DNA REPAIR271Figure 5-42 The recogn
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DNA REPAIR273produces G, which cann
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DNA REPAIR275(A) NONHOMOLOGOUS END
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HOMOLOGOUS RECOMBINATION277sequence
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HOMOLOGOUS RECOMBINATION2795′3′
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HOMOLOGOUS RECOMBINATION281Figure 5
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HOMOLOGOUS RECOMBINATION2835′3′
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HOMOLOGOUS RECOMBINATION285DNAMOVES
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TRANSPOSITION AND CONSERVATIVE SITE
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299How Cells Read the Genome:From D
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FROM DNA TO RNA301Figure 6-2 Schema
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FROM DNA TO RNA303Figure 6-6 Uracil
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FROM DNA TO RNA305modern DNA polyme
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FROM DNA TO RNA307(A)closed complex
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FROM DNA TO RNA3095′3′DNA of E.
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FROM DNA TO RNA311Table 6-3 The Gen
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FROM DNA TO RNA313enhancer(binding
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FROM DNA TO RNA315(A)EUKARYOTES(B)P
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FROM DNA TO RNA317Figure 6-22 Eukar
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FROM DNA TO RNA3195′3′exonsintr
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FROM DNA TO RNA321The Spliceosome U
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FROM DNA TO RNA323intronexon ~200in
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FROM DNA TO RNA32510-30 nucleotides
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FROM DNA TO RNA327hnRNPproteinsSR p
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FROM DNA TO RNA329(A)HO(B)OCHN NHba
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FROM DNA TO RNA331ribosomalproteins
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FROM RNA TO PROTEIN333granule clust
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FROM RNA TO PROTEIN335attached amin
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FROM RNA TO PROTEIN337PHriboseNNONN
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FROM RNA TO PROTEIN339(A)tRNA5′3
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FROM RNA TO PROTEIN34170S80SMW 2,50
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FROM RNA TO PROTEIN343Figure 6-63 T
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FROM RNA TO PROTEIN345Figure 6-66 R
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FROM RNA TO PROTEIN347RNA core, whi
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FROM RNA TO PROTEIN349P Pribosome-b
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FROM RNA TO PROTEIN351Inhibitors of
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FROM RNA TO PROTEIN353start codonin
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FROM RNA TO PROTEIN355growingpolype
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FROM RNA TO PROTEIN357Although our
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FROM RNA TO PROTEIN359(A)(B)hexamer
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FROM RNA TO PROTEIN361which directs
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THE RNA WORLD AND THE ORIGINS OF LI
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THE RNA WORLD AND THE ORIGINS OF LI
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369Control of Gene Expressionchapte
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AN OVERVIEW OF GENE CONTROL371no. o
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CONTROL OF TRANSCRIPTION BY SEQUENC
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377β SHEET DNA RECOGNITION PROTEIN
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TRANSCRIPTION REGULATORS SWITCH GEN
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TRANSCRIPTION REGULATORS AS GENE SW
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TRANSCRIPTION REGULATORS AS GENE SW
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MOLECULAR GENETIC MECHANISMS THAT C
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MECHANISMS THAT REINFORCE CELL MEMO
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POST-TRANSCRIPTIONAL CONTROLS413DNA
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POST-TRANSCRIPTIONAL CONTROLS415Fig
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POST-TRANSCRIPTIONAL CONTROLS417Unt
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POST-TRANSCRIPTIONAL CONTROLS419apo
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POST-TRANSCRIPTIONAL CONTROLS421If,
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POST-TRANSCRIPTIONAL CONTROLS423for
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POST-TRANSCRIPTIONAL CONTROLS425sca
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POST-TRANSCRIPTIONAL CONTROLS427AAA
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REGULATION OF GENE EXPRESSION BY NO
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IIIPARTIII IV VWAYS OF WORKING WITH
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ISOLATING CELLS AND GROWING THEM IN
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ISOLATING CELLS AND GROWING THEM IN
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PURIFYING PROTEINS445indefinitely s
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PURIFYING PROTEINS447(A)VELOCITYSED
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PURIFYING PROTEINS449solvent flow s
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PURIFYING PROTEINS451In other cases
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ANALYZING PROTEINS453(A)cathodesamp
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ANALYZING PROTEINS455(A)(B)gel onto
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ANALYZING PROTEINS457acid and then
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ANALYZING PROTEINS459FASTTUMBLINGde
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ANALYZING PROTEINS461x-ray diffract
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ANALYZING AND MANIPULATING DNA463se
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ANALYZING AND MANIPULATING DNA4655
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ANALYZING AND MANIPULATING DNA467Pu
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ANALYZING AND MANIPULATING DNA469ba
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ANALYZING AND MANIPULATING DNA471PR
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ANALYZING AND MANIPULATING DNA473hy
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ANALYZING AND MANIPULATING DNA475ch
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ANALYZING AND MANIPULATING DNA477Wi
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479SEQUENCING WHOLE GENOMESShotgun
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481ION TORRENT SEQUENCINGAnother wi
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ANALYZING AND MANIPULATING DNA483ge
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STUDYING GENE EXPRESSION AND FUNCTI
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487TYPES OF MUTATIONSDELETION: dele
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MATHEMATICAL ANALYSIS OF CELL FUNCT
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529Visualizing Cellschapter9Underst
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LOOKING AT CELLS IN THE LIGHT MICRO
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LOOKING at CELLS IN THE LIGHT MICRO
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LOOKING at CELLS IN THE LIGHT MICRO
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LOOKING AT CELLS AND MOLECULES IN T
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IIIPARTIII IV VInternal Organizatio
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THE LIPID BILAYER567hydrophilichead
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THE LIPID BILAYER569(A)hydrogen bon
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THE LIPID BILAYER571are catalyzed b
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THE LIPID BILAYER573cholesteroltran
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THE LIPID BILAYER575Glycolipids Are
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MEMBRANE PROTEINS57786NH 2PPlipidbi
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MEMBRANE PROTEINS579membrane protei
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MEMBRANE PROTEINS581lipidbilayerFig
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MEMBRANE PROTEINS583(A)carbohydrate
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MEMBRANE PROTEINS585hydrophobictail
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MEMBRANE PROTEINS587(A)patch ofbact
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MEMBRANE PROTEINS589newly fusedhybr
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MEMBRANE PROTEINS591anterior headpo
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MEMBRANE PROTEINS593plasmamembrane(
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597Membrane Transport of SmallMolec
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PRINCIPLES OF MEMBRANE TRANSPORT599
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TRANSPORTERS AND ACTIVE MEMBRANE TR
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channels and the electrical PROPERT
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channels and the electrical propert
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chapter 11 end-of-chapter problems6
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641Intracellular Compartmentsand Pr
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THE ComparTMENTALIZATION OF CELLS64
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THE TRANSPORT OF MOLECULES BETWEEN
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THE TRANSPORT OF PROTEINS INTO MITO
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PEROXISOMES667Catalase uses the H 2
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THE ENDOPLASMIC RETICULUM669preexis
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THE ENDOPLASMIC RETICULUM671nucleus
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THE ENDOPLASMIC RETICULUM673mRNA5
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MBoC6 m12.41/12.41THE ENDOPLASMIC R
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THE ENDOPLASMIC RETICULUM677Figure
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THE ENDOPLASMIC RETICULUM679stop-tr
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THE ENDOPLASMIC RETICULUM681stop-tr
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THE ENDOPLASMIC RETICULUM683(A)NH 2
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THE ENDOPLASMIC RETICULUM685Oligosa
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THE ENDOPLASMIC RETICULUM687How do
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THE ENDOPLASMIC RETICULUM689fatty a
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THE ENDOPLASMIC RETICULUM691As disc
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695Intracellular Membrane Trafficch
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THE MOLECULAR MECHANISMS OF MEMBRAN
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TRANSPORT FROM THE ER THROUGH THE G
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TRANSPORT FROM THE TRANS GOLGI NETW
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TRANSPORT INTO THE CELL FROM THE PL
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753Energy Conversion:Mitochondria a
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THE MITOCHONDRION755(A)MITOCHONDRIO
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THE MITOCHONDRION757Figure 14-7 Int
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THE MITOCHONDRION759MATRIXFOOD MOLE
Page 796 and 797:
THE MITOCHONDRION761Finally, mitoch
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THE PROTON PUMPS OF THE ELECTRON-TR
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PANEL 14-1: Redox Potentials 765HOW
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ATP PRODUCTION IN MITOCHONDRIA775Ta
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ATP PRODUCTION IN MITOCHONDRIA777fl
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ATP PRODUCTION IN MITOCHONDRIA779(A
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ATP PRODUCTION IN MITOCHONDRIA781H
Page 818 and 819:
CHLOROPLASTS AND PHOTOSYNTHESIS783L
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CHLOROPLASTS AND PHOTOSYNTHESIS785C
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CHLOROPLASTS AND PHOTOSYNTHESIS787L
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CHLOROPLASTS AND PHOTOSYNTHESIS789l
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CHLOROPLASTS AND PHOTOSYNTHESIS7912
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CHLOROPLASTS AND PHOTOSYNTHESIS793T
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CHLOROPLASTS AND PHOTOSYNTHESIS795F
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CHLOROPLASTS AND PHOTOSYNTHESIS797O
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CHLOROPLASTS AND PHOTOSYNTHESIS799c
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THE GENETIC SYSTEMS OF MITOCHONDRIA
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REFERENCES811D. If it takes 468 kJ/
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813Cell Signalingchapter15When thin
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PRINCIPLES OF CELL SIGNALING815(A)(
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PRINCIPLES OF CELL SIGNALING817ABCA
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PRINCIPLES OF CELL SIGNALING819more
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PRINCIPLES OF CELL SIGNALING821GAPP
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PRINCIPLES OF CELL SIGNALING823(A)
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PRINCIPLES OF CELL SIGNALING825over
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PRINCIPLES OF CELL SIGNALING827rela
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PRINCIPLES OF CELL SIGNALING829sign
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PRINCIPLES OF CELL SIGNALING831rece
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SIGNALING THROUGH G-PROTEIN-COUPLED
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SIGNALING THROUGH ENZYME-COUPLED RE
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ALTERNATIVE SIGNALING ROUTES IN GEN
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SIGNALING IN PLANTS881Notch, Wnt, o
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SIGNALING IN PLANTS883(A)(B) ABSENC
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SIGNALING IN PLANTS885CYTOSOLRED LI
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889The Cytoskeletonchapter16For cel
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PANEL 16-1: The Three Major Types o
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FUNCTION AND ORIGIN OF THE CYTOSKEL
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ACTIN AND ACTIN-BINDING PROTEINS899
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903NUCLEOTIDE HYDROLYSISEach actin
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PANEL 16-3 : Actin Filaments 905ACT
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MYOSIN AND ACTIN915150 nmneck or hi
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MYOSIN AND ACTIN917minusendactin fi
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myofibrilMYOSIN AND ACTIN919Figure
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MYOSIN AND ACTIN921transverse (T)tu
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MYOSIN AND ACTIN923muscle: its myos
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MYOSIN AND ACTIN925(A)headMyosin V3
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MICROTUBULES927Figure 16-43 The pre
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MICROTUBULES929time 0 sec 125 sec 3
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MICROTUBULES931nucleating sites(γ-
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PANEL 16-4 : Microtubules 933MICROT
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MICROTUBULES935(A)1 2 3 4 5(B)5 µm
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MICROTUBULES937Figure 16-57 The mec
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MICROTUBULES939A clear example of t
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MICROTUBULES941body all the way to
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MICROTUBULES943many structural feat
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MICROTUBULES945(A)NH 2COOHα-helica
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INTERMEDIATE FILAMENTS AND SEPTINS9
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INTERMEDIATE FILAMENTS AND SEPTINS9
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CELL POLARIZATION AND MIGRATION951C
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CELL POLARIZATION AND MIGRATION953(
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CELL POLARIZATION AND MIGRATION955F
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distance (nm)CHAPTER 16 END-OF-CHAP
Page 998 and 999:
963The Cell Cyclechapter17The only
Page 1000 and 1001:
OVERVIEW OF THE CELL CYCLE965mitosi
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THE CELL-CYCLE CONTROL SYSTEM967Sum
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THE CELL-CYCLE CONTROL SYSTEM969G 1
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THE CELL-CYCLE CONTROL SYSTEM971Cdk
Page 1008 and 1009:
THE CELL-CYCLE CONTROL SYSTEM973Tab
Page 1010 and 1011:
S PHASE975G 1Sprereplicative comple
Page 1012 and 1013:
S PHASE977hinge(A)Smc moleculeCNATP
Page 1014 and 1015:
MITOSIS979M-cyclininhibitoryphospha
Page 1016 and 1017:
9814ANAPHASEshorteningkinetochoremi
Page 1018 and 1019:
MITOSIS983spindle polecentrosome+ +
Page 1020 and 1021:
MITOSIS985G 1 S G 2MFigure 17-26 Ce
Page 1022 and 1023:
MITOSIS987-+nucleation-++++-+- ---+
Page 1024 and 1025:
MITOSIS989+(A) (B) (C) (D) (E)++ ++
Page 1026 and 1027:
MITOSIS991How does plus-end depolym
Page 1028 and 1029:
MITOSIS993inactive APC /CcohesinM-C
Page 1030 and 1031:
MITOSIS995ANAPHASE AANAPHASE BSegre
Page 1032 and 1033:
CYTOKINESIS997remaining interpolar
Page 1034 and 1035:
CYTOKINESIS999astral stimulation mo
Page 1036 and 1037:
CYTOKINESIS1001preprophase band of
Page 1038 and 1039:
CYTOKINESIS1003NUCLEARDIVISIONSNUCL
Page 1040 and 1041:
MEIOSIS1005each other and become ph
Page 1042 and 1043:
MEIOSIS1007axial coresof thehomolog
Page 1044 and 1045:
MEIOSIS1009localized at the kinetoc
Page 1046 and 1047:
CONTROL OF CELL DIVISION AND CELL G
Page 1048 and 1049:
Page 1050 and 1051:
Page 1052 and 1053:
Page 1054 and 1055:
Page 1056 and 1057:
1021Cell Deathchapter18The growth,
Page 1058 and 1059:
CELL DEATH1023adaptorbindingdomainp
Page 1060 and 1061:
CELL DEATH1025killer lymphocyteFas
Page 1062 and 1063:
CELL DEATH1027anti-apoptoticBcl2 fa
Page 1064 and 1065:
CELL DEATH1029IAPs Help Control Cas
Page 1066 and 1067:
CELL DEATH1031underlying mechanism
Page 1068 and 1069:
Page 1070 and 1071:
III1035PARTIII IV VCells in Their S
Page 1072 and 1073:
CELL JUNCTIONS AND THE EXTRACELLULA
Page 1074 and 1075:
CELL-CELL JUNCTIONS1039classical ca
Page 1076 and 1077:
CELL-CELL JUNCTIONS1041(A)(B)50 µm
Page 1078 and 1079:
CELL-CELL JUNCTIONS1043membrane pro
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CELL-CELL JUNCTIONS1045adhesion bel
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CELL-CELL JUNCTIONS1047Tight Juncti
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CELL-CELL JUNCTIONS1049microvilliin
Page 1086 and 1087:
CELL-CELL JUNCTIONS1051largegapjunc
Page 1088 and 1089:
CELL-CELL JUNCTIONS1053Figure 19-26
Page 1090 and 1091:
CELL-CELL JUNCTIONS1055lectin domai
Page 1092 and 1093:
THE EXTRACELLULAR MATRIX OF ANIMALS
Page 1094 and 1095:
THE EXTRACELLULAR MatrIX OF ANIMALS
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Page 1098 and 1099:
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CELL-MatrIX JUNCTIONS1075Integrins
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CELL-MatrIX JUNCTIONS1077receptor o
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CELL-MatrIX JUNCTIONS1079Integrins
Page 1116 and 1117:
CELL-MATRIX JUNCTIONS1081TALINNinte
Page 1118 and 1119:
THE PLANT CELL WALL1083animal extra
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THE PLANT CELL WALL1085turgorpressu
Page 1122 and 1123:
THE PLANT CELL WALL1087In this way,
Page 1124 and 1125:
REFERENCES108919-12 At body tempera
Page 1126 and 1127:
1091Cancerchapter20About one in fiv
Page 1128 and 1129:
CANCER AS A MICROEVOLUTIONARY PROCE
Page 1130 and 1131:
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Page 1138 and 1139:
Page 1140 and 1141:
CANCER-CRITICAL GENES: HOW THEY ARE
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Page 1144 and 1145:
Page 1146 and 1147:
YMBoC6 n20.250/20.24YCANCER-CRITICA
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MBoC6 n20.290/20.28CANCER-CRITICAL
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Page 1160 and 1161:
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CANCER PREVENTION AND TREATMENT: PR
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Page 1168 and 1169:
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1145Development ofMulticellular Org
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OVERVIEW OF DEVELOPMENT1147OVERVIEW
Page 1184 and 1185:
OVERVIEW OF DEVELOPMENT1149Genes In
Page 1186 and 1187:
OVERVIEW OF DEVELOPMENT1151source o
Page 1188 and 1189:
OVERVIEW OF DEVELOPMENT1153Figure 2
Page 1190 and 1191:
MECHANISMS OF patterN FORMatION1155
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MECHANISMS OF PATTERN FORMATION1159
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DEVELOPMENTAL TIMING1177the molecul
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DEVELOPMENtaL TIMING1179(A)inhibito
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DEVELOPMENtaL TIMING1181timefirst-s
Page 1218 and 1219:
DEVELOPMENtaL TIMING1183cells at th
Page 1220 and 1221:
MORPHOGENESIS1185from the propertie
Page 1222 and 1223:
MORPHOGENESIS1187Figure 21-47 Effec
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MORPHOGENESIS1189(A)lamellipodia at
Page 1226 and 1227:
MORPHOGENESIS1191FGF10 made byclust
Page 1228 and 1229:
GROWTH1193SummaryAnimal development
Page 1230 and 1231:
GROWTH119510 µm(A)(B)10 µm(C) (D)
Page 1232 and 1233:
GROWTH1197wild typemyostatin mutant
Page 1234 and 1235:
NEURAL DEVELOPMENT1199Figure 21-67
Page 1236 and 1237:
NEURAL DEVELOPMENT1201embryoniccere
Page 1238 and 1239:
NEURAL DEVELOPMENT1203extracellular
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NEURAL DEVELOPMENT1205lipsnosefaceu
Page 1242 and 1243:
NEURAL DEVELOPMENT1207(A)wild-type
Page 1244 and 1245:
NEURAL DEVELOPMENT1209motorneuronge
Page 1246 and 1247:
NEURAL DEVELOPMENT1211Synaptic Prun
Page 1248 and 1249:
Page 1250 and 1251:
REFERENCES1215(A)control(A)anterior
Page 1252 and 1253:
1217Stem Cells andTissue Renewalcha
Page 1254 and 1255:
STEM CELLS AND RENEWAL IN EPITHELIA
Page 1256 and 1257:
STEM CELLS AND Renewal IN EPITHELIA
Page 1258 and 1259:
Page 1260 and 1261:
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Page 1264 and 1265:
FIBROBLASTS AND THEIR TRANSFORmatio
Page 1266 and 1267:
FIBROBLASTS AND THEIR TRANSFORMATIO
Page 1268 and 1269:
GENESIS AND REGENERATION OF SKELETA
Page 1270 and 1271:
BLOOD VESSELS, LYMPHATICS, AND ENDO
Page 1272 and 1273:
BLOOD VESSELS, LYMPHATICS, AND ENDO
Page 1274 and 1275:
A HIERARCHICAL STEM-CELL SYSTEM: BL
Page 1276 and 1277:
Page 1278 and 1279:
Page 1280 and 1281:
Page 1282 and 1283:
REGENERation AND RepaiR1247Bcl2 pro
Page 1284 and 1285:
REGENERATION AND REPAIR1249(A)irrad
Page 1286 and 1287:
CELL REPROGRAMMING AND PLURIPOTENT
Page 1288 and 1289:
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Page 1298 and 1299:
1263Pathogens and Infectionchapter2
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INTRODUCTION TO PATHOGENS AND THE H
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Page 1306 and 1307:
Page 1308 and 1309:
Page 1310 and 1311:
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CELL BIOLOGY OF INFECTION1277adapto
Page 1314 and 1315:
CELL BIOLOGY OF INFECTION1279machin
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CELL BIOLOGY OF INFECTION1281pumped
Page 1318 and 1319:
CELL BIOLOGY OF INFECTION1283parasi
Page 1320 and 1321:
CELL BIOLOGY OF INFECTION1285earlye
Page 1322 and 1323:
CELL BIOLOGY OF INFECTION1287nucleo
Page 1324 and 1325:
CELL BIOLOGY OF INFECTION1289Lister
Page 1326 and 1327:
CELL BIOLOGY OF INFECTION1291also e
Page 1328 and 1329:
CELL BIOLOGY OF INFECTION1293cell m
Page 1330 and 1331:
Page 1332 and 1333:
1297The Innate and AdaptiveImmune S
Page 1334 and 1335:
THE INNATE IMMUNE SYSTEM1299Figure
Page 1336 and 1337:
THE INNATE IMMUNE SYSTEM1301The act
Page 1338 and 1339:
THE INNATE IMMUNE SYSTEM1303ability
Page 1340 and 1341:
THE INNATE IMMUNE SYSTEM1305inactiv
Page 1342 and 1343:
OVERVIEW OF THE ADAPTIVE IMMUNE SYS
Page 1344 and 1345:
Page 1346 and 1347:
Page 1348 and 1349:
Page 1350 and 1351:
B CELLS AND IMMUNOGLOBULINS1315Myas
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B CELLS AND IMMUNOGLOBULINS1317intr
Page 1354 and 1355:
B CELLS AND IMMUNOGLOBULINS1319vari
Page 1356 and 1357:
MBoC6 m25.37/24.31B CELLS AND IMMUN
Page 1358 and 1359:
B CELLS AND IMMUNOGLOBULINS1323VDJ
Page 1360 and 1361:
T CELLS AND MHC PROTEINS1325they ei
Page 1362 and 1363:
T CELLS AND MHC PROTEINS1327recepto
Page 1364 and 1365:
T CELLS AND MHC PROTEINS1329and pre
Page 1366 and 1367:
T CELLS AND MHC PROTEINS1331able to
Page 1368 and 1369:
T CELLS AND MHC PROTEINS1333Figure
Page 1370 and 1371:
T CELLS AND MHC PROTEINS1335Effecto
Page 1372 and 1373:
T CELLS AND MHC PROTEINS1337βαBCR
Page 1374 and 1375:
T CELLS AND MHC PROTEINS1339In both
Page 1376 and 1377:
Page 1378 and 1379:
G:1GlossaryABC transporters A large
Page 1380 and 1381:
Glossary G:3on the basal lamina tha
Page 1382 and 1383:
Glossary G:5carcinoma Cancer of epi
Page 1384 and 1385:
Glossary G:7co-receptor In immunolo
Page 1386 and 1387:
Glossary G:9electrons from cytochro
Page 1388 and 1389:
Glossary G:11giving rise to all the
Page 1390 and 1391:
Glossary G:13free-energy change (
Page 1392 and 1393:
Glossary G:15Hedgehog protein Secre
Page 1394 and 1395:
Glossary G:17inner nuclear membrane
Page 1396 and 1397:
Glossary G:19lysosomal storage dise
Page 1398 and 1399:
Glossary G:21multipass transmembran
Page 1400 and 1401:
Glossary G:23specific G protein (Go
Page 1402 and 1403:
Glossary G:25environment in small v
Page 1404 and 1405:
Glossary G:27a specific voltage sen
Page 1406 and 1407:
Glossary G:29scanning electron micr
Page 1408 and 1409:
Glossary G:31mammalian cell cycle w
Page 1410 and 1411:
Glossary G:33transmembrane adhesion
Page 1412 and 1413:
I:1IndexNoteThe index covers the ma
Page 1414 and 1415:
Index I:3amino acidsabbreviations 1
Page 1416 and 1417:
Index I:5gene segments 1319-1320, 1
Page 1418 and 1419:
Index I:7calnexin 685, 712calreticu
Page 1420 and 1421:
Index I:9cell proliferationaccompan
Page 1422 and 1423:
Index I:11polytene chromosomes 208-
Page 1424 and 1425:
Index I:13crime see forensic scienc
Page 1426 and 1427:
Index I:15linked to mutations 479,
Page 1428 and 1429:
Index I:17electron crystallography
Page 1430 and 1431:
Index I:19regulation of protein syn
Page 1432 and 1433:
Index I:21epigenetic inheritance an
Page 1434 and 1435:
Index I:23Gleevec ® 1135, 1136FGli
Page 1436 and 1437:
Index I:25HIV (human immunodeficien
Page 1438 and 1439:
Index I:27morphogens in 1151, 1153s
Page 1440 and 1441:
Index I:29lateral diffusion in bila
Page 1442 and 1443:
Index I:31medaka fish 547FMediator
Page 1444 and 1445:
Index I:33in evolution of large org
Page 1446 and 1447:
Index I:35optogenetic control in mi
Page 1448 and 1449:
Index I:37p53 proteinapoptosis-prom
Page 1450 and 1451:
Index I:39plasma, distinguished fro
Page 1452 and 1453:
Index I:41immunoglobulin fold 121mo
Page 1454 and 1455:
Index I:43bacterial 249Feukaryotic
Page 1456 and 1457:
Index I:45introduced 695, 696Fsecre
Page 1458 and 1459:
Index I:47specimen preparationelect
Page 1460 and 1461:
Index I:49tetheringby disordered re
Page 1462 and 1463:
Index I:51γ-tubulin 929, 930F, 982
Page 1464 and 1465:
Index I:53of ADP/ATP carrier protei
Page 1469:
Enterprise HouseNewHelens StreetStD
Page 1474 and 1475:
Renegade:Adjective‘Having rejecte
Page 1476 and 1477:
How the few control the many and al
Page 1478 and 1479:
Somewhere you can hear my voiceI kn
Page 1480 and 1481:
ContentsCHAPTER 1CHAPTER 2CHAPTER 3
Page 1482 and 1483:
why perception is the target 24/7 o
Page 1484 and 1485:
governments, corporations and autho
Page 1486 and 1487:
new deals’ demanding that very ce
Page 1488 and 1489:
away. Fascists do not impose fascis
Page 1490 and 1491:
The perceptual download continues t
Page 1492 and 1493:
convince themselves to believe the
Page 1494 and 1495:
One is akin to pushing against an o
Page 1496 and 1497:
Order’ used by Cult frontmen like
Page 1498 and 1499:
manufacturing both the ‘problem
Page 1500 and 1501:
population at the bo om under their
Page 1502 and 1503:
lockdown house arrest is brutally e
Page 1504 and 1505:
Cult?’ and ‘Escaping Wetiko’.
Page 1506 and 1507:
window rolled down automatically. V
Page 1508 and 1509:
subjected to mass control because h
Page 1510 and 1511:
politicians. While operating throug
Page 1512 and 1513:
I have exposed them in fine detail
Page 1514 and 1515:
and detailed background in other wo
Page 1516 and 1517:
manipulate your people into the pos
Page 1518 and 1519:
be the manipulating force behind th
Page 1520 and 1521:
Figure 8: Liberty’s mirror image
Page 1522 and 1523:
a acked Jews, not least in his book
Page 1524 and 1525:
at the Cult-owned World Economic Fo
Page 1526 and 1527:
Revolution ‘by these internationa
Page 1528 and 1529:
through a global network of organis
Page 1530 and 1531:
instigated Second World War that he
Page 1532 and 1533:
business empire collapsing as a for
Page 1534 and 1535:
There are so many constituent scams
Page 1536 and 1537:
successful presidential campaigns.
Page 1538 and 1539:
allegiance to Sabbatian-controlled
Page 1540 and 1541:
hate’ hate groups to condemn anyo
Page 1542 and 1543:
CHAPTER THREEThe Pushbacker stingUn
Page 1544 and 1545:
what you want to hear than those wh
Page 1546 and 1547:
Trump Derangement Syndrome as it be
Page 1548 and 1549:
times before over 30 years under di
Page 1550 and 1551:
connections - like all major busine
Page 1552 and 1553:
insurrectionists and conspiracy the
Page 1554 and 1555:
standby given the strength of feeli
Page 1556 and 1557:
invaded the building at gunpoint an
Page 1558 and 1559:
obviously pre-planned assault was l
Page 1560 and 1561:
This disingenuous lady may one day
Page 1562 and 1563:
children are in reality teenage boy
Page 1564 and 1565:
use diversion and division to targe
Page 1566 and 1567:
denied an income and the right to e
Page 1568 and 1569:
ProPublica, National Journal, The G
Page 1570 and 1571:
fascist shutdown orders and took th
Page 1572 and 1573:
would have been with a ‘deadly bi
Page 1574 and 1575:
when both are serving the same Cult
Page 1576 and 1577:
There we have the prophetic Rockefe
Page 1578 and 1579:
controlled World Health Organizatio
Page 1580 and 1581:
The Cult plays the long game and pr
Page 1582 and 1583:
January, 2020. This was ‘before C
Page 1584 and 1585:
pivotal position in American health
Page 1586 and 1587:
is naturally in the body or relates
Page 1588 and 1589:
The question must be asked of what
Page 1590 and 1591:
clueless and only repeating the par
Page 1592 and 1593:
be moving westward and it somehow m
Page 1594 and 1595:
Why China?Scamming the world with a
Page 1596 and 1597:
developed close economic, military,
Page 1598 and 1599:
think that the conspiracy involved
Page 1600 and 1601:
CHAPTER FIVEThere is no ‘virus’
Page 1602 and 1603:
The pyramid structure through which
Page 1604 and 1605:
official who will probably have the
Page 1606 and 1607:
include doctors who go through life
Page 1608 and 1609:
Mullis asked why their work had bee
Page 1610 and 1611:
ridiculous. ‘Everybody knows’ t
Page 1612 and 1613:
then follow the postulates sequence
Page 1614 and 1615:
some 40 Freedom of Information requ
Page 1616 and 1617:
Here’s your ‘virus’ - it’s
Page 1618 and 1619:
The shocking thing about the above
Page 1620 and 1621:
conduct control experiments to see
Page 1622 and 1623:
If you were to look in the scientif
Page 1624 and 1625:
far indistinguishable from human me
Page 1626 and 1627:
eugenics of the Third Reich in Nazi
Page 1628 and 1629:
was from the beginning a computer-g
Page 1630 and 1631:
animated video explanation on david
Page 1632 and 1633:
billion people having ‘flu-like
Page 1634 and 1635:
Italy was a redesignation of diagno
Page 1636 and 1637:
will feel panicky and less able to
Page 1638 and 1639:
monumentally wrong? Ah, but it make
Page 1640 and 1641:
cows. Fewer than 200 deaths followe
Page 1642 and 1643:
paper that would serve as legitimiz
Page 1644 and 1645:
elderly’. Rosemary Frei highlight
Page 1646 and 1647:
and death projections for the gover
Page 1648 and 1649:
University. She analysed the impact
Page 1650 and 1651:
the 5G system of millimetre waves w
Page 1652 and 1653:
and died of a chronic illness yet h
Page 1654 and 1655:
The nightly shroud-waving and shock
Page 1656 and 1657:
that lockdown fascism was to ‘pro
Page 1658 and 1659:
thousands of old people who tested
Page 1660 and 1661:
‘War-zone’ hospitals mythAgain
Page 1662 and 1663:
in power were rather less concerned
Page 1664 and 1665:
the definition of a ‘vaccine’,
Page 1666 and 1667:
to the average age that people die
Page 1668 and 1669:
CHAPTER SEVENWar on your mindOne be
Page 1670 and 1671:
Facebook, Google, Amazon and their
Page 1672 and 1673:
The reason for the ‘Covid’ cata
Page 1674 and 1675:
‘behavioural scientists, health a
Page 1676 and 1677:
Hurd went to the elite Eton College
Page 1678 and 1679:
support pu ing London under a lockd
Page 1680 and 1681:
and military or a compliant populat
Page 1682 and 1683:
particularly among the young denied
Page 1684 and 1685:
a United Nations rapporteur (invest
Page 1686 and 1687:
you’ … ‘My heart aches for so
Page 1688 and 1689:
founded on mind control. Three word
Page 1690 and 1691:
alone with a woman that’s not the
Page 1692 and 1693:
researching mind control in detail
Page 1694 and 1695:
masks, why they have been enforced
Page 1696 and 1697:
potential consequences. She said it
Page 1698 and 1699:
wear a mask that was absolutely ine
Page 1700 and 1701:
We were told that the world could g
Page 1702 and 1703:
geologists found tiny plastic fibre
Page 1704 and 1705:
Against masks: Breathing in your ow
Page 1706 and 1707:
respect, always has been, always wi
Page 1708 and 1709:
subservience to an abusive partner.
Page 1710 and 1711:
has a questioning and critical mind
Page 1712 and 1713:
benefits if the a itudes are person
Page 1714 and 1715:
NHS over ‘Covid’ and we have se
Page 1716 and 1717:
carefully constructed language. An
Page 1718 and 1719:
themselves and each other - peer to
Page 1720 and 1721:
An example is the policeman who wou
Page 1722 and 1723:
mental and emotional processes that
Page 1724 and 1725:
officer’ for US Special Forces. R
Page 1726 and 1727:
Woke are the same. See if you find
Page 1728 and 1729:
shops, transport companies and busi
Page 1730 and 1731:
obsession: Preparing collective per
Page 1732 and 1733:
you are dealing with the unquestion
Page 1734 and 1735:
and a er $15 million was deleted fr
Page 1736 and 1737:
and see Old Glory trampled in the d
Page 1738 and 1739:
organisation that supports violent
Page 1740 and 1741:
Marxist takeovers. Our cultural pas
Page 1742 and 1743:
with the Rockefellers and Rothschil
Page 1744 and 1745:
Private jets for climate justiceThe
Page 1746 and 1747:
domestic pets, to humans. Just befo
Page 1748 and 1749:
change’. He said the effect of Co
Page 1750 and 1751:
Figure 9: The idea that the gas of
Page 1752 and 1753:
them - including, no especially, th
Page 1754 and 1755:
companies immunity from prosecution
Page 1756 and 1757:
manipulated figures of the World He
Page 1758 and 1759:
transcription’ can convert RNA in
Page 1760 and 1761:
UK doctor and freedom campaigner Ve
Page 1762 and 1763:
it targets DNA. The Johnson & Johns
Page 1764 and 1765:
If you wanted to depopulate a signi
Page 1766 and 1767:
word ‘genocide’ for what was ha
Page 1768 and 1769:
was dead, but naturally the vaccina
Page 1770 and 1771:
‘vaccine’. Another seven ‘vac
Page 1772 and 1773:
reported and I have seen some estim
Page 1774 and 1775:
and Big Pharma-dominated Medicines
Page 1776 and 1777:
‘vaccinations’ were seriously u
Page 1778 and 1779:
not ‘vaccines’ made the differe
Page 1780 and 1781:
the jabs that ‘confer immunity’
Page 1782 and 1783:
humanity and condemned his plans to
Page 1784 and 1785:
airport. They are jailed in internm
Page 1786 and 1787:
they are for getting their vaccine.
Page 1788 and 1789:
obviously affects breathing and wou
Page 1790 and 1791:
disease which can lead to Alzheimer
Page 1792 and 1793:
shops etc. It’s time covid-denyin
Page 1794 and 1795:
cloud in our brains ... We’re goi
Page 1796 and 1797:
at any moment to deliver its payloa
Page 1798 and 1799:
radiation which is information can
Page 1800 and 1801:
Peter Diamandis, can be seen in a w
Page 1802 and 1803:
destroyed by persuading the Cult-cr
Page 1804 and 1805:
These are all dots in the same pict
Page 1806 and 1807:
Many women’s rights organisations
Page 1808 and 1809:
where the government published plan
Page 1810 and 1811:
significantly of all unvaccinated w
Page 1812 and 1813:
for those in power. A Forbes articl
Page 1814 and 1815:
about. Researchers were investigati
Page 1816 and 1817:
Sabbatians have taken over the cybe
Page 1818 and 1819:
percent (Fig 11 overleaf). Take thi
Page 1820 and 1821:
a state of being aware. Forget ‘f
Page 1822 and 1823:
Yes, what is ‘human’? That is w
Page 1824 and 1825:
Figure 12: The brain receives infor
Page 1826 and 1827:
sub-conscious mind. This explanatio
Page 1828 and 1829:
Figure 14: How holograms are create
Page 1830 and 1831:
The question will be asked of why,
Page 1832 and 1833:
which becomes behaviour which, coll
Page 1834 and 1835:
Reptilian Agenda recorded at his th
Page 1836 and 1837:
unseen realms which means almost al
Page 1838 and 1839:
crucial to that as we shall see. In
Page 1840 and 1841:
Yaldabaoth and the Archons are said
Page 1842 and 1843:
seen as a ‘god’ capable of ‘m
Page 1844 and 1845:
Figure 17: Artist Neil Hague’s ve
Page 1846 and 1847:
have a particular pre-puberty energ
Page 1848 and 1849:
exclusion claimed to inclusion; and
Page 1850 and 1851:
which it controls through ‘money
Page 1852 and 1853:
become very different to the origin
Page 1854 and 1855:
Kurzweil’s ‘cloud’? The plan
Page 1856 and 1857:
is transmi ed to the brain as elect
Page 1858 and 1859:
existence of a simulation means tha
Page 1860 and 1861:
in a $2.3 trillion ‘coronavirus
Page 1862 and 1863:
Propulsion Laboratory, has said pub
Page 1864 and 1865:
Wow …The reality that humanity th
Page 1866 and 1867:
CHAPTER TWELVEEscaping WetikoLife i
Page 1868 and 1869:
realms of possibility which allow e
Page 1870 and 1871:
the operator (Fig 21). Indigenous a
Page 1872 and 1873:
they have no compassion or empathy
Page 1874 and 1875:
wetikoized mind.’ Wetiko consciou
Page 1876 and 1877:
possession) can be anything from ex
Page 1878 and 1879:
hierarchies, corporate media, Silic
Page 1880 and 1881:
changes and that can only change by
Page 1882 and 1883:
Earth. SpaceX, like everyone else,
Page 1884 and 1885:
centrally control all water and foo
Page 1886 and 1887:
and absorb human consciousness - wh
Page 1888 and 1889:
protest in Bristol in which police
Page 1890 and 1891:
beating the elite in court and he f
Page 1892 and 1893:
their thuggery and crimes they will
Page 1894 and 1895:
yes to the question you are unknowi
Page 1896 and 1897:
‘wheels of light’ in the Sanskr
Page 1898 and 1899:
heart is connected to that level of
Page 1900 and 1901:
This would create a human that is r
Page 1902 and 1903:
it is, but enough of this nonsense.
Page 1904 and 1905:
PostscriptThe big scare story as th
Page 1906 and 1907:
time to destroy the harvest. This d
Page 1908 and 1909:
Smart Grid and break the receiver-t
Page 1910 and 1911:
paramagnetic particles’. Sensitiv
Page 1912 and 1913:
The scale of madness, inhumanity an
Page 1914 and 1915:
more than 2,000 wires ‘fanned out
Page 1916 and 1917:
War US President Woodrow Wilson not
Page 1918 and 1919:
of the ‘Covid vaccines’ and did
Page 1920 and 1921:
park. Eventually the Nappies turned
Page 1922 and 1923:
Flame on burn desireLove with tongu
Page 1924 and 1925:
In as concise terms as possible, he
Page 1926 and 1927:
The observation that the unpurified
Page 1928 and 1929:
BibliographyAlinsky, Saul: Rules fo
Page 1930 and 1931:
IndexArelationshipsabusiveblaming t
Page 1932 and 1933:
finance and money ref1, ref2, ref3b
Page 1934 and 1935:
fact-checkers ref1masks ref1media r
Page 1936 and 1937:
Nag Hammadi texts ref1, ref2, ref3R
Page 1938 and 1939:
ref1cyber-operationsref1cyberwarfar
Page 1940 and 1941:
Archons ref1censorship ref1, ref2,
Page 1942 and 1943:
the Field ref1, ref2 5G ref3, ref4,
Page 1944 and 1945:
perception ref1political parties re
Page 1946 and 1947:
see social distancing and isolation
Page 1948 and 1949:
Silicon Valley ref1Torah ref1United
Page 1950 and 1951:
perception ref1, ref2Psyop (psychol
Page 1952 and 1953:
Programming (NLP) and the Delphi te
Page 1954 and 1955:
Common Purpose ref1defunding ref1lo
Page 1956 and 1957:
Archons ref1, ref2consciousness ref
Page 1958 and 1959:
Israel ref1Sabbatians ref1technocra
Page 1960 and 1961:
Tsee also artificial intelligence (
Page 1962 and 1963:
immigration, effects of illegal ref
Page 1964 and 1965:
implantable technology ref1Israel r
Page 1966 and 1967:
fear ref1, ref2frequency ref1, ref2
Page 1968 and 1969:
transgender ref1, ref2, ref3, ref4,
Page 1977:
Before you go …For more detail, b
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Molecular Biology of the Cell by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter by by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morg

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