Molecular Biology of the Cell by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter by by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morg

Index I:27
morphogens in 1151, 1153
sequential induction 1153–1154, 1160
in vertebrate embryos 1167F, 1177,
1184, 1198
infants
antibody transport in newborns 737
birth defects 1154
infection strategies 1276–1294
infectious diseases
immunity and the adaptive immune
system 1297
mortality 1263
see also pathogens
inflammasomes 1301
inflammatory response
and cancer 1132
and pathogens 1300–1301
and white blood cells 1240
influenza virus
as a disease-causing virus 1265,
1273T
effect on host-cell transcription 1288
genome reassortment 1291, 1292F
infection by endocytosis 709,
1280–1281
influenza A 1273T, 1280
negative strand genome 1289
nomenclature 1292F
pandemics 1291, 1292F
structures 1274
inheritance
chromosome-wide gene expression
changes 409–411
of organelles 648, 807
see also heredity
inhibitors of protein function 459–460
inhibitory neurotransmitters 629
inhibitory postsynaptic potential 633
inhibitory signals, sequential 820, 821F
initiation factors
eIFs (eukaryotic initiation factors) 347,
348F, 423–428
for IRES 425
phosphorylation 423–424
initiator caspases 1022–1025, 1028
initiator proteins 254–255, 256–257F, 259
innate immune responses
speed of 1298
Toll and Toll-like receptors 1165
innate immune system
as first line of defense 1298–1306
natural killer cells in 1304
innate lymphoid cells 1326
innexins 1051
inosine, in tRNA 336, 337F
inositol 1,4,5-trisphosphate (IP 3 ) 837, 847
inositol phospholipid signaling pathways
836, 848, 852, 853F, 861
inositol phospholipids (phosphoinositides)
572, 574, 836
phosphatidylinositol (PI) 377F, 574
profilin binding 906
see also PIPs
insect vectors 1276
insertional mutagenesis 488, 491
insulator DNA sequences 391, 409
insulin
action via receptor tyrosine kinases
850T
assembly 130
deletion of thymocytes recognizing
1332
PI 3-kinase-Akt signaling pathway and
860, 1114–1115
recycling endosomes and 738
secretion by pancreatic β-cells 1226
insulin receptor 823, 850T, 851–852
Int1 gene 869
integrases 291
integration, intracellular signaling systems
825
integrin clusters and 1079
integrins
active and inactive conformations
1077–1078
binding sites 1075
in cell adhesion and motility 955–956,
959
cytoplasmic tyrosine kinases and
862–863
fibronectin binding 1067–1068
intracellular signaling proteins and
1079–1080
α L β 2 integrin (LFA1) 1055F, 1076T,
1077
as matrix receptors 1074
mediation of cell-cell adhesion 1038,
1054, 1077
mediation of cell-matrix junctions
1037F, 1038
α- and β-subunits 1075
as transmembrane adhesion proteins
1037
types of 1076T
interacting proteins, identifying 457–458
interaction domains 822–824, 852–853,
860
interchromatin granule clusters 213,
331–333
interference effects, in microscopy 531,
532F, 550
interferon-α (IFNα)
as a cytokine 1304
JAK-STAT signaling pathway and
864T, 1304
interferon-β (IFNβ) 1304
interferon-γ (IFNγ)
from helper T effector cells
1335–1336
JAK-STAT signaling pathway and
864T
as a Type II interferon 1304
interleukins
IL1 (interleukin-1) 873, 1257F, 1301
IL3 1257F
IL4 1336
IL5 1335F
IL6 1301, 1335F, 1336
IL10 1335F, 1336
IL12 1301, 1335
IL13 1335F
IL17 1301, 1335F, 1336
IL21 1335F, 1336
intermediate filaments
assembly 124, 946
in cell migration 959
desmosomes and 1036, 1045–1046
flexibility and stretch 895F
hemidesmosomes and 1076
and the nuclear envelope 890
and the nuclear lamina 891, 944
and septins 944–950
intermembrane space, mitochondria 658,
663–664
internal membranes
chloroplasts 27F
eukaryotic cells 24
mitochondria 26F
interphase
as cell cycle stage 185, 964
chromosome state in 185–188, 198,
207–208, 209F
components 964, 965F
interpolar microtubules 982
intestinal crypts 1122, 1124, 1218–1219
intracellular compartments see organelles
intracellular development programs 1179,
1200
intracellular pathogens 1278–1279, 1282,
1283F, 1284–1285
intracellular signaling cascades see
enzyme cascades
intracellular signaling complexes 822,
823F, 851F, 859
intracellular signaling pathways 814
combating noise 820–822
interaction domains 822–824,
852–853, 860
in plants 880–885
response behaviors 824–825
response speeds and turnover rate
825–826
see also signaling pathways
intracellular signaling proteins 578, 700,
814, 1079–1080
intraepithelial neoplasia 1131
intragenic mutations 16, 17F
intralumenal vesicles 724F, 729–730,
735–737, 738F
intrinsic activation pathway, apoptosis
1023–1029
anti-cancer drugs binding to Bcl2
1031
Bcl2 regulation 1025–1028
mitochondrial involvement 1025
intron sequence ambiguities 416
introns (intervening sequences)
consensus nucleotide sequences
319F
discovery 417
evolution rate 220F
in human genome 183F, 184, 224F,
318F
self-splicing 324
size range 319, 321
transcribed, removal by RNA splicing
315–316, 317–318, 320F, 336
unique removal by IRE1 688
invadopodia 952
invariant membrane proteins 1316–1317,
1326, 1336
invariant polypeptide chains, BCR/TCR
1327F, 1328–1329, 1330F, 1337F,
1338
invariant sections, MHC protein 1331
invasin 1281
inversion mutations 487
inverted repeats 289, 603, 604F, 676F
ion-channel-coupled receptors 817F, 818,
843
ion channels
all-or-nothing opening 626
Page numbers with an F refer to a figure; page numbers with a T refer to a table.