Molecular Biology of the Cell by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter by by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morg

Index I:35
optogenetic control in mice 624
presynaptic and postsynaptic
628–629
programmed production 1201F
RNA localization 421
secretory vesicles 744–746
stathmin role in amygdala 935
structure and function 620–621, 940
survival factors 1030F
sympathetic 1018
turnover rate 1250
types and firing properties 627
types of ion channel 614, 631
visualizing in mouse brain 502F
see also axons; central nervous
system; dendrites; glial cells;
synapses
“neurospheres” 1250, 1251F
Neurospora 416–417
neurotransmitter receptors
ionotropic and metabotropic 630
neurotransmitter transporters 603, 604F,
628
neurotransmitters
binding to transmitter-gated channels
629
excitatory and inhibitory 629–630
as extracellular signaling molecules
815–818, 825
in synaptic vesicles 745–746
see also transmitter-gated ion
channels
neurotrophic factors 1208–1209
neurotropic alpha herpesviruses 1288
neutrophils 1239, 1240F, 1241,
1244–1246
chemotaxis 958, 959F
CSFs and production of 1245
cytoskeletal rearrangements 890, 892
as professional phagocytes 739,
740F, 1301
newts
limb regeneration 1248–1249
lung cells 991
NFκB signaling pathway 873–874, 1301
NGF (nerve growth factor)
action via MAP kinases 856
action via receptor tyrosine kinases
850T, 853–854
as a neurotrophic factor 1208–1209
sympathetic neuron growth and 1018
NHEJ see nonhomologous end joining
NHL (non-Hodgkin’s lymphoma) 1092F
nicotinamide derivatives see NADH;
NADPH
nidogen 1058F, 1070, 1071F
nitric oxide (NO) 846–847
nitrogen cycle 85–86
nitrogen fixation 12, 14F, 86
nitrogen in C-N chemical groups 91
nitroglycerine 847
nitrosated polyamines and peptides 267T
nitroxide spin labels 569–570
NLRs (NOD-like receptors) 1300–1301
NMDA receptors (N-methyl-D-aspartate)
636–637
NMR (nuclear magnetic resonance)
studies
of human brain 913F
of protein structure 461–462
of transcription regulators 375
nocodazole 904T
NOD-like receptors (NLRs) 1300
Nodal protein 1168–1169
nodes of Ranvier 625
Noggin protein 1168–1169
noise
in data points 525
in genetic control systems 1246
in intracellular signaling 820–822, 831
in microscope images 532–533, 561
non-crossovers 284–286
non-genetic variability 524
non-histone proteins 187, 209–210
nonclassical cadherins 1037T, 1038,
1039F, 1046F
noncoding DNA
conserved 224–225
in humans and other species 28–29,
182
in the nucleolus 330
regulatory DNA as 7, 29
see also introns
noncoding RNAs 305, 327
localization with in situ hybridization
502
regulation of gene expression
429–436
RNA sequencing and 482
small ncRNAs and RNA interference
429–431
noncovalent interactions/noncovalent
bonds
in biological membranes 565
cytoskeletal filaments 893
four types 44–45, 45T, 94–95
ligand binding 134, 139F, 140
in macromolecules 49–50
membrane-associated proteins 577
in protein folding 110–111, 114
nondisjunction 1010, 1109F
nonenveloped viruses 1274, 1280–1281
nonfibrillar collagens 1063T
nonhomologous end joining (NHEJ)
274–275, 282, 289
B cell switch sequences 1323
homologous recombination and 275F,
278
nonretroviral retrotransposons 291–292
nonsense-mediated mRNA decay 327F,
352–353
normal flora 1264–1265, 1276, 1293,
1298
NOS (NO synthases) 847
Notch protein
activation by proteolysis 869F
O-glycosylation 720, 868
Notch receptor 867–868, 869F, 1117
Notch signaling pathway
diversity 1150
Hes genes 1178
lateral inhibition 1152, 1171–1173,
1224–1225
stem cell maintenance 1224–1225
notochords 1147F, 1167, 1185F, 1189F,
1200F
Noxa protein 1028
NPCs see nuclear pore complexes
NPV (human papillomavirus) 1131–1132
NSF protein 709, 712F
NtrC protein 383F
nuclear envelope
DNA localization and 178–179
Page numbers with an F refer to a figure; page numbers with a T refer to a table.
as feature of eukaryotes 24
inner and outer membranes 649
intermediate filaments and 890
linker proteins 948–949
in mitosis 656–657, 978, 980–981,
985–986, 995
repair factory tethering 213–214
nuclear export signals/receptors 652–655
nuclear import signals/receptors 650,
652, 653F, 654–656
nuclear lamina
heterochromatin and 211–212
intermediate filaments and 179, 180F,
891, 944
in mitosis 656, 986, 995
role 649, 650F
nuclear lamins
A-type lamins 948
caspase cleavage of 1023
nuclear localization signals 650–651,
652–653F, 654–655, 657
amino acid phosphorylation 655
import receptor binding 652
nuclear matrix or scaffold 214
nuclear pore complexes (NPCs)
arrangement 651F
export of mRNA-protein complexes
326–327
gated transport 646
import receptor binding 652
phosphorylation in mitosis 985
Ran-GTPase and 653–654
virus entry 1281
nuclear pores 179, 180F, 202F, 213, 327,
559F, 561F
nuclear receptor superfamily 875–876,
877F
nuclear reprogramming 1252–1253
nuclear-to-cytoplasmic ratio 1182
nuclear transplantation 1252
nuclear transport receptors 326, 653
nucleation, actin filament formation
899–900, 902, 906–907,
908–909F, 953, 954F, 1289F
nuclei
as characteristic of eukaryotes 13
DNA virus replication 1278
human chromosome localization
211–212, 213F
as intracellular compartments 642
loss from red blood cells 1245F
noncoding RNAs 327–330
protein import 649
RNA export 325–327, 419–421, 649,
655
subcompartments and structures
213–214, 331–333
transplanted into enucleated eggs
205, 206F, 369–370
transport between cytosol and
649–658
nucleic acid structures 1101
nucleic acid synthesis 71–72
nucleoids 759, 800F
nucleolus 213, 329–330, 331F, 340
snoRNAs 305T, 328
nucleoporins 126, 649–650, 651F, 656
nucleoside triphosphate hydrolysis 894,
896, 902–903
see also ATP hydrolysis; GTP
hydrolysis