Molecular Biology of the Cell by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter by by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morg

Index I:25
HIV (human immunodeficiency virus)
and cancer 1130T, 1132
capsid structure 562F
combination therapies 1140
detecting in samples 475F
diversification from SIV 1291F
genome 420F
infection and membrane fusion 709,
710F
invasion of helper T cells 1332
regulated nuclear transport and
419–421
replication errors and evolution 1291
transcription attenuation 414
HIV-1 1273T, 1286, 1289, 1291
receptors required 1279–1280
HLA proteins (human leukocyte
associated) 1327
HNPCC (hereditary nonpolyposis
colorectal cancer) 250,
1124–1125
hnRNPs (heterogeneous nuclear
ribonucleoproteins) 323F, 326
Holliday junctions 283F, 284–285
homeodomain family 120, 122, 378F
homeodomain motif 376, 1163
homeostatic mechanisms 1195, 1217,
1226, 1247
homeotic selector see Hox
Homo sapiens
as a eukaryote 16F
as a model organism 29T, 33,
491–492
homogenates
cell-free systems 451
from subcellular fractionation 445
homolog pairing 1005F, 1006–1007
homologous chromosomes
and imprinting 408F
segregation in meiosis I 1008
homologous genes 216
homologous protein species
interchangeability 1146
homologous recombination 276–287
BRCA1 and BRCA2 defects 266T,
267
cellular regulation of 280–282
double strand break repair 275,
278–279, 1116, 1133–1134
in meiosis 282–285
in transgenic organisms 495, 497,
498F
use by cancer cells 1100
homologs
in human cells 180
orthologs and paralogs as 17–18
homophilic binding
axon growth 1202
cadherins and 1038–1042, 1202
contrasted with heterophilic 1039F
DSCAM proteins 1207
immunoglobulin superfamily and
1055, 1056F, 1202
sealing strands 1048
homotypic membrane fusion 712, 721,
748
homunculi 1155, 1205
Hooke, Robert 439, 1081
horizontal gene transfer
antibiotic resistance 19, 289, 1269,
1292–1293
in prokaryotes 18–20
sexual reproduction and 19–20
as source of innovation 16, 17F
three mechanisms 1268
hormone-secreting pituitary cells 840
hormones
in extracellular signaling 815
gene expression response 372, 400
in hematopoiesis 1244
melatonin 877
moderated by cyclic AMP 835T
production through DNA cloning 484
somatostatin 835–836
steroid hormones 875–876
timing of developmental transitions
1182
horseradish peroxidase 735F
horseshoe crab 223
housekeeping genes 406, 407F
Hox (homeotic selector) complex
cell memory and 1164
in humans 1169
serial gene expression 1163–1164,
1169
Hox genes 1162–1164
in pattern refinement 1161–1164,
1169
rhombomeres and 1188
HP1 (heterochromatin-specific protein)
197, 200F, 202F, 204F, 206,
210–211
HPLC (high-performance liquid
chromatography) 449, 457
HPV (human papillomaviruses) 1131,
1265, 1273T
HS4 barrier sequences 202
hsp60 (heat shock protein) 355–357, 662
hsp70 protein family
BiP 683
clathrin removal 702
hsp60 and 355–357
mitochondrial 659, 660–661F, 662
human body
daily ATP turnover in 774
as a microbiological ecosystem
1263–1264
mutation rate 1091, 1094, 1095F
number of cells and cell types 2,
1091, 1217, 1264
number of lymphocytes 1308
proteins unique to humans 122
human brain, number of neurons 627,
1198
human cells
limit on divisions 1016
tRNA and anticodon numbers 336
human chromosome 5 472F
human chromosome 6 132F, 1327
human chromosome 9 472F, 1093, 1094F,
1135F
human chromosome 13 1108
human chromosome 22
compaction in mitosis 187
sample section 183F
translocation with chromosome 9
1093, 1094F, 1135F
human female, errors in meiosis 1010
human genome
analysis, and medical treatment 506
conserved regions as functional 217
evidence of migrations 232
gene density and gene size in 182,
184
as genetic model 36– 37
haplotype blocks 492
human mitochondrial genome
801–802F, 804–805
MHC polymorphisms 1331
mobile genetic elements 218F
mobile genetic elements in 218F, 287,
291–292
mouse genome compared with 220F,
221–222
mutation rates 238
number of genes and proportion
expressed 371
number of genes coding for collagens
1062
number of genes coding for Golgi
enzymes 718
number of genes coding for
intermediate filaments 944, 946
number of genes coding for ion
channels 635
number of genes coding for orphan
receptors 875
number of genes coding for
phosphatases and kinases 819
number of genes coding for receptor
proteins 814, 832
number of mcRNAs produced 429,
435
number of nucleotides 28, 37, 175,
183F, 184T
other statistics 184T
proportion of cancer-critical genes
1112–1113
protein-coding genes 120, 122–123
replication origins 260–261
sample section of chromosome 22
183F
sample section of X-chromosome
300F
size 178, 179, 184T
variability 38, 232–234
human genome project
genomic DNA cloning 471
repetitive DNA problem 479
human microbiota 1263–1275, 1277
human population
as a genetic model 491–492
genome-wide association studies 493
population growth and genetic
variation 231
Hunchback transcription activator 393F,
394, 395F, 1161F, 1179
huntingtin gene 224F
hyaluronan 1057F, 1058–1060, 1061F
hybridization
nucleotide sequences from 472
in recombinant DNA technology 464,
473
in situ hybridization 502, 536
hybridization (DNA)
and homologous recombination
277–278
in microarrays 257, 258F
hybridomas 444
hydride ions, NADH and NADPH 67–68
hydrocarbon tails, fats 83, 98–99
hydrocarbons
as hydrophobic 44, 92
Page numbers with an F refer to a figure; page numbers with a T refer to a table.