Molecular Biology of the Cell by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter by by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morg

Index I:45
introduced 695, 696F
secretory granules 132
secretory proteins
active precursors 743–744
aggregation in TGN 742–743
secretory vesicles
budding from TGN 716, 742
endocytosis 744F
exocytosis 741–744
localization 744
maturation and acidification 743
membrane removal by endocytosis
746–748
phosphoinositides in 701F
Rab3a in 706T
synaptic vesicles as 745
securin 971, 973, 978, 992–994, 1009
sedimentation velocity and equilibrium
446–447
segment-polarity genes 1159–1162
segmental duplications, double strand
breaks 228
segmentation clock 1178–1179
segmentation genes
insect bodies 1159, 1160F
regulatory hierarchy 1161F
in vertebrates 1177
selectins 720
cell-cell adhesion 1054–1055
E-, L- and P-selectin 1054–1055
homing receptors 1312
structure and function 1055F
selective advantage see natural selection
selectivity filters, ion channels 613, 618,
619F, 622F
selenocysteine 350
self-amplification
caspase cascade in apoptosis 1023
complement cascade 1303
of embryonic asymmetry 1152
of nerve impulses 621, 623
of Rab domains 707
self-assembly
in cells 9, 128–129
glycolipids 575
lipid bilayers 566
self-association, cytoskeletal filaments
893, 897
self-organization, embryonic development
1145
self-phosphorylation, P-type pumps 607
self-renewing tissues 1120, 1217
self-sealing, lipid bilayers 568, 569F
self-tolerance see immunological
self-tolerance
“selfish DNA” see mobile genetic elements
SEM (scanning electron microscopy)
chick embryo neural tube 1192F
frog neuromuscular junction 630F
fungal infection on Drosophila 1299F
NK cell attacking a cancer cell 1304F
olfactory neuron cilia 844F
osteoclast on bone matrix 1231F
pericytes 1236F
principles 558–561
semiconservative replication
of centrosomes 984
of DNA 240, 242F, 447
Semliki forest virus 1275F
senescence see replicative cell
senescence
sensitive period, visual system 1212
sensitivity of target cells 824
sensory mother cells 1172, 1173F
sensory neurons 1172, 1208–1209
separases 993, 1009
septins 949–950, 959, 999
septum, Z-ring and 896
sequence logos 308, 375, 378F
sequential induction 1153–1154, 1160
serine
phosphatidyl- 566–567, 571T, 574
phosphorylation during transcription
388F
phosphorylation in RNA polymerase
tails 312, 316–317
phosphorylation in the nucleosome
196–197
structure 113
serine kinases in protein kinase evolution
155F
serine proteases 1072
Asp-His-Ser catalytic triad in 136F
complement system 1302
domain shuffling in 121F, 123
elastase and chymotrypsin compared
119F
as a protein family 119, 121F
serine/threonine kinases
AKT as 860
distinguished from tyrosine kinases
819–820
PKA as 834–835
plant photoproteins 884
serotonin
as an excitatory neurotransmitter 629
cyclic AMP response 834F
GPCRs activated by 832
serotonin secretion 1218, 1219F, 1239,
1241T
serum, distinguished from plasma 1011
seven-pass transmembrane proteins
Frizzled as 870
Smoothened as 872
see also G-protein coupled receptors
Sevenless (Sev) RTK 855
sex chromosomes
in different organisms 486
dosage compensation and 410
as nonhomologous 180
X-chromosome sample sequence
300F
X-inactivation 410–411, 412F, 1252
sex hormones 99, 875–876
sexual reproduction
haploid-diploid cycle 486
homologous recombination and 277,
282
and horizontal gene transfer 19–20
see also meiosis
shadowing (electron microscopy) 560
SH2 (Src homology 2) domains
as an interaction domain 822, 824F
in cytoplasmic tyrosine kinases 862
evolutionary tracing 136–137
multicellularity and 122
phosphorylation and 154, 156
phosphotyrosine binding via 852–855,
859, 863, 864F
positioning role 135
structure 115–116, 118F
versatility 121–122
SH3 (Src homology 3) domains
as an interaction domain 822, 824F
binding to proline-rich domains 853
inhibitory action 118F, 122, 156, 157F
tyrosine kinases and 854–855, 863,
864F
in ZO scaffold proteins 1050F
shelterins 263
shibire mutant, Drosophila 702F
Shigella flexneri 1268, 1284F, 1287,
1288–1289F
Shine-Dalgarno sequence 348, 349F,
422, 423F
shotgun sequencing 479
shugoshin 1009
shuttle system, NADH 760
shuttling proteins 654
sialic acids 575, 717, 1056, 1279, 1303
Sic1 protein 973T, 1003–1004
sigma (σ) factors 306, 307–308F,
309–310, 384
sigmoidal relationships 517
sigmoidal responses 827–828, 841
signal hypothesis 672, 673F
signal patches 647, 728, 729F
signal peptidases 647, 664, 673, 677
signal processing, intracellular 825
signal-processing proteins
Src kinase example 155–156, 157F
types of response to signal
concentrations 827–831
signal-recognition particles see SRPs
signal sequences
amino acid sequences 647, 648T
discovery 672
internal 659, 663F, 664, 677–679,
680–681F
within sorting signals 647
for successful gene transfer 801
translocation into chloroplasts and
664–666
translocation into endoplasmic
reticulum 672–675, 677
translocation into mitochondria and
659, 661F, 663
translocation into peroxisomes and
667–668
signal transduction, cell-surface receptors
818
signal variability
among cell populations 829
as noise 822
signaling centers 1153, 1160, 1167–1168,
1178
signaling hubs, Ras and Rho as 854
signaling mechanisms
compared 158F
in nerve cells 621
see also cell signaling
signaling molecules
response and turnover 825–826
see also hormones
signaling pathways
discovery in Drosophila embryos
1154
Hedgehog pathway 1150, 1154, 1160
JAK-STAT signaling pathway
863–864, 1304
NFκB signaling pathway 873–874,
1301
PI 3-kinase-Akt signaling pathway
860–861, 1017, 1030F
Page numbers with an F refer to a figure; page numbers with a T refer to a table.