Diagnostic ultrasound ( PDFDrive )

70 PART I Physics
Enhancement
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Time
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FIG. 3.18, cont’d (B) Time-intensity replenishment curves for each of the 25 slices, measured simultaneously. The total acquisition time is
about 15 seconds; the contrast agent is Deinity.
A
B
FIG. 3.19 Molecular Ultrasound Imaging of Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2) With Targeted Microbubbles.
Figure shows 40-MHz images of a MeWo subdermal tumor derived from human melanoma cells in a mouse after injection of VEGFR-2–targeted
microbubbles. (A) Circulating bubbles have left the vascular system; those imaged are adhering to the receptor target. Microbubble-speciic signal
is shown as a green overlay. (B) After disruption lash, the bubble echoes disappear. The difference in bubble signal between these two images
quantiies adhesion of the tracer to the target receptor. Scale units are millimeters. (Reproduced with permission from Rychak JJ, Graba J, Cheung
AM, et al. Microultrasound molecular imaging of vascular endothelial growth factor receptor 2 in a mouse model of tumor angiogenesis. Mol
Imaging. 2007;6[5]:289-296. 103 )