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570 PART II Abdominal and Pelvic Sonography

FIG. 16.6 Postmenopausal Large Ovarian Cyst. TVS image of a

7-cm ovarian cyst that contains no internal echoes or septations and

had not changed in size over 4 years.

and greater than 1 cm in diameter be followed by serial yearly

sonographic examinations without surgical intervention unless

there is an increase in size or change in the characteristics of

the lesion. Cysts measuring less than 1 cm are felt to be almost

certainly benign and follow-up is not necessary. Surgery is usually

recommended for postmenopausal simple cysts greater than 7 cm

and for those containing multiple internal septations or one or

more solid nodules. However, magnetic resonance imaging (MRI)

is better able to characterize these larger cysts in which small

mural nodules can be missed by ultrasound and thus may be a

reasonable alternative to surgery. 28

NONNEOPLASTIC LESIONS

Functional Cysts

Functional cysts are physiologic and not neoplastic lesions of

the ovary whose appearance and disappearance is hormonally

driven. hese cysts may be simple or hemorrhagic and are commonly

divided into three categories: follicular, corpus luteum,

and theca lutein cysts. Acute abdominal pain caused by internal

hemorrhage, rupture, or leakage is the most common symptom,

but pelvic discomfort may simply be the result of the large size,

greater than 2.5 to 3.0 cm.

A follicular cyst develops when a mature follicle fails to ovulate

or to involute. Because normal follicles can vary from a few

millimeters up to 2.5 cm, a follicular cyst cannot be diagnosed

with certainty until it is larger than 2.5 cm. herefore a simple

cyst less than 2.5 cm in a premenopausal woman should be

referred to as a follicle and considered to be normal. Follicles

and follicular cysts are usually unilateral, asymptomatic, and

frequently detected incidentally on sonographic examination.

Follicular cysts usually regress spontaneously.

Ater ovulation, the corpus luteum develops and may be

identiied sonographically as a small, hypoechoic or isoechoic

structure within the ovary. he corpus luteum usually contains

low-level internal echoes, frequently with a thicker wall than a

follicle and a crenulated appearance. It typically has a peripheral

rim of color around the wall on color Doppler ultrasound (ring

of ire; see Fig. 16.3C). he corpus luteum usually involutes before

menstruation but may persist because of failure of absorption

or internal bleeding. Timor-Tritsch and Goldstein 35 recommend

using the term corpus luteum rather than corpus lutein cyst unless

it is greater than 4 cm. Corpus lutein cysts are less common than

follicular cysts but tend to be larger and more symptomatic. Pain

is the major symptom. hese cysts are usually unilateral and are

prone to hemorrhage and, less commonly, rupture. If the ovum

is fertilized, the corpus luteum continues as the corpus luteum

of pregnancy, which may become enlarged with a simpler cystic

appearance than the original corpus luteum. Maximum size is

reached at 8 to 10 weeks of gestation, and by 16 weeks the cyst

has usually resolved. 36

heca lutein cysts are associated with high beta–human

chorionic gonadotropin (B-hCG) levels and are the largest of

the functional ovarian cysts, increasing the risk of ovarian torsion.

hese cysts typically occur in patients with gestational trophoblastic

disease but can also be seen as a complication of drug

therapy for infertility causing ovarian hyperstimulation syndrome.

Sonographically, theca lutein cysts are usually bilateral, multilocular,

and very large. Similar to other functional cysts, they

may undergo hemorrhage or rupture.

Although hemorrhage may occur in all types of functional

cysts, it is most frequently seen in corpus luteal cysts. Women

with hemorrhagic cysts frequently present with acute onset of

pelvic pain. Hemorrhagic cysts show a spectrum of indings

because of the variable sonographic appearance of blood (Fig.

16.7, Video 16.2). he appearance depends on the amount of

hemorrhage and the time of the hemorrhage relative to the time

of the sonographic examination. 37-39 he internal architecture is

much better appreciated on TVS when compared to TAS because

of its superior resolution. An acute hemorrhagic cyst is usually

hyperechoic and may mimic a solid mass. However, it usually

has a smooth posterior wall and shows posterior acoustic enhancement,

indicating the cystic nature of the lesion. Difuse low-level

internal echoes may be appreciated, although this appearance

is more frequently seen in endometriomas. As the clot hemolyzes,

a reticular-type pattern is demonstrated internally containing

intertwining linear internal echoes representing ibrin strands. 40

hese should not be confused with septations, which are thicker.

As the clot retracts, it will have a concave outer margin with

angularity compared with a solid mural nodule, which will have

a convex outer margin. Color Doppler ultrasound will show no

low within the clot but will demonstrate peripheral vascularity

within the cyst wall. Care should be taken when assessing for

low in hemorrhagic cysts, because a clot can move and show

color without true vascularity. Spectral Doppler can be helpful

in these cases. Patel et al. 40 found that a speciic diagnosis could

be made in approximately 90% of hemorrhagic cysts by demonstrating

the presence of a reticular pattern or a retractile clot.

he presence of echogenic, free intraperitoneal luid in the

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