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CHAPTER 46 Duplex Sonography of the Neonatal and Infant Brain 1583

A

B

C

D

FIG. 46.9 Seven-Week-Old Infant With Progressive Liver Failure, Severe Neurologic Deterioration, and Brain Death. (A) Initial ultrasound

study and pulsed wave Doppler tracing from anterior cerebral artery appear unremarkable. (B) Follow-up imaging during devastating neurologic

deterioration shows no relevant brain perfusion on power Doppler imaging. (C) Sagittal midline power Doppler imaging also fails to show venous

low within the superior sagittal sinus, conirming lack of brain perfusion. (D) Complete lack of brain perfusion was also conirmed by nuclear medicine

perfusion study.

decrease in the I/E ratio was more prominent for the EDV compared

with the peak systolic low velocity and time average low

velocity. 60

VASCULAR MALFORMATIONS

Pediatric cerebral arteriovenous malformations (AVMs) difer

substantially from adult forms in their angioarchitecture, clinical

presentation, systemic hemodynamic impact, and overall functional

outcome. 61 Pediatric AVMs are frequently istulous or

multifocal, oten exert a hemodynamic efect on the entire venous

system, and rarely manifest with high low–related vasculopathy

or low-related aneurysms. Systemic manifestations with cardiac

overload are a key clinical feature increasing morbidity and

mortality. Chronic venous stasis and/or ischemia in combination

with a vascular steal may cause chronic cardiac insuiciency

and result in irreversible brain damage. he so-called “melting

brain” is a well-known devastating complication of the vein of

Galen aneurysmal malformation (VGAM), which is the most

common neonatal intracranial vascular malformation. Diferentiation

between “true” and “false” VGAM is essential. 62 In the true

VGAM, arteries drain directly into a dilated, persisting interhemispheric

prosencephalic vein (Markowski vein) without

connection to the deep venous system. In “false” VGAM, subpial

AVMs adjacent to the cerebellum, brainstem, or deep supratentorial

territories drain into a normally developed vein of Galen,

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