31.05.2018 Views

4. Uluslararası Beyaz Et Kongresi

Bildiriler Kitabı

Bildiriler Kitabı

SHOW MORE
SHOW LESS

You also want an ePaper? Increase the reach of your titles

YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.

Sonuç olarak, LA hem yağda hem de suda çözünebilen tek antioksidandır. Okside antioksidanları<br />

indirgeyerek yeniden antioksidan özellik kazandırabilmekte ve mitokondri içinde güçlü bir<br />

antioksidan olarak aktivite göstermektedir. Bu anlamda “mucize bir antioksidan (19) ve evrensel<br />

antioksidan (13, 14)” olarak tanımlanır. LA’nın kanatlı kümes hayvanlarının metabolizmasına<br />

ve yemlerinde tek veya diğer antioksidanlarla birlikte kullanımına yönelik daha fazla bilimsel<br />

çalışmalara ihtiyaç duyulmaktadır.<br />

Kaynaklar<br />

1. Packer L, Witt EH, Tritschler HJ. Alpha-Lipoic acid as a biological antioxidant. Free Radic.<br />

Biol. Med. 1995; 19: 227-250.<br />

2. Reed LJ, Busk BG, Gunsalus IC, Schnakenberg GHF. Crystalline a lipoic-acid: a catalytic<br />

agent associated with pyruvate dehydrogenase. Science, 1951; 114: 93-9<strong>4.</strong><br />

3. Gomes MB, Negrato CA. Alpha-lipoic acid as a pleiotropic compound with potential<br />

therapeutic use in diabetes and other chronic diseases. Diabetology & Metabolic Syndrome,<br />

2014; 6: 80.<br />

<strong>4.</strong> Krämer K, Packer L. Nutraceuticals in Health and Disease Prevention: R-α-Lipoic Acid.<br />

Marcel Dekker Incorporated, New York. 2001; 9:143.<br />

5. Gözükara EM. Biyokimya. İnonu Universitesi Tıp Fakultesi yayınları Malatya: 1989;<br />

55,56,705,845-848.<br />

6 Bullock MW, Brockamann JA, Patterson EL, Pierce JV, Macchi ME. Proposed structures for<br />

protogen-A and protogen-B. J.Am. Chem Soc., 1954; 76: 1827-1828.<br />

7. Biewenga GP, Haenen GRMM, Bast A. The pharmacology of the antioxidant: Lipoic acid.<br />

Gen. Pharmacol., 1997; 29: 315–331.<br />

8. Roy S, Packer L. Redox regulation of cell functionsby alpha-lipoate: biochemical and<br />

molecular aspects. Biofactors, 1998; 8: 17-21.<br />

9. Jacob S, Streeper RS, Fogt DL, Hokama JY, Tritschler HJ, Dietze GJ, Henriksen EJ. The<br />

antioxidant alphalipoic acid enhances insulin-stimulated glucose metabolism in insulinresistant<br />

rat skeletal muscle. Diabetes, 1996b; 45:1024-1029.<br />

10. Streeper RS, Henriksen EJ, Jacob S, Hokama JY, Fogt DL, Tritschler HJ. Differential effects<br />

of lipoic acid stereoisomers on glucose metabolism in insulin-resistant skeletal muscle. Am.<br />

J. Physiol., 1997; 273:E185-191.<br />

11. Jacob S, Henriksen EJ, Schiemann AL, Simon I, Clancy DE, Tritschler HJ, Jung WI, Augustin<br />

HJ, Dietze GJ. Enhancement of glucose disposal in patients with type 2 diabetes by alphalipoic<br />

acid. Arzneimittelforschung, 1995; 45: 872-87<strong>4.</strong><br />

12. Evans JL, Goldfine ID. Alpha-lipoic acid: a multifunctional antioxidant that improves insulin<br />

sensitivity in patients with type 2 diabetes. Diabetes Technol. Ther., 2000; 2: 401413.<br />

13. Rozzana MS, Zaiton Z, Rajikin MH, Fadzilah S, Zanariyah A. Supplementation with<br />

Alpha Lipoic Acid improves the in vitro development of embryos in nicotine-treated mice.<br />

Biomedical Research, 2005; 16 (1): 28-32<br />

1<strong>4.</strong> Karaca EG. Lipoik asit: evrensel antioksidan. AKÜ-Fen Bilimleri Dergisi, 2007; 8(1):231-<br />

245.<br />

15. Zhang Y, Hongtrakul K, Ji C, Ma QG, Liu LT, Hu XX. Effects of dietary alpha-lipoic acid<br />

on anti-oxidative ability and meat quality in Arbor Acres broilers. Asian-Aust. J. Anim. Sci,<br />

2009; 22: 1195-1201.<br />

707

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!