MDCK-MRP2 - Dkfz

134
Forschungsschwerpunkt B
Funktionelle und Strukturelle Genomforschung
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*Pfreundschuh*, M., Lichter, P., *Trümper, L. (2001) MDM2 gene
amplification and lack of p53 point mutations in Hodgkin and
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reaction and molecular cytogenetic studies. Br. J. Haematol. 112,
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Lichter, P., *Barth, T.F.E. (2002) Classical Hodgkin’s lymphoma is
characterized by recurrent copy number gains of the short arm
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cell lines are characterized by frequent aberrations on
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Gains of 2p involving the REL locus correlate with nuclear c-Rel
protein accumulation in neoplastic cells of classical Hodgkin’s lymphoma.
Blood 101(9), 3681-3686
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*Schwarzbach, M., *Otano-Joos, M., Ohl, S., *Högel, J.,
*Lehnert, T., Lichter, P., *Otto, H.F., *Mechtersheimer, G. (2002)
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*Wessendorf, S., Nessling, M., Korz, C., *Rieker, R, *Bentz, M.,
*Montgomery, K., *Kucherlapati, R., *Mechtersheimer, G., Eils,
R., Joos, S., Lichter, P. (2002) Microarray based copy number
and expression profiling in dedifferentiated and pleomorphic liposarcoma.
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Lichter, P., *Mühling, J., Freier, K. (2002) [Opportunities and
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[19] Freier, K., Joos, S., *Flechtenmacher, C., Devens, F.,
Benner, A., *Bosch, F.X., Lichter, P., *Hofele, C. (2003) Tissue
microarray analysis reveals site-specific prevalence of onogene
amplifications in head and neck squamous cell carcinoma. Cancer
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[20] Freier, K., *Bosch, F.X., *Flechtenmacher, C., Devens, F.,
Benner, A., Lichter, P., Joos, S., *Hofele, C. (2003) Distinct sitespecific
oncoprotein overexpression in head and neck squamous
cell carcinoma: A tissue microarray analysis. Anticancer Res. 23
(5A), 3971-3977
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P., Joos, S.,*Schackert, G. (2003) Independent molecular development
of metachronous glioblastomas with long-term recurrence
free time. Brain Pathol. 13 (4):598-607
[22] *Weber, R.G., *Rieger, J., *Naumann, U., Lichter, P.,
*Weller, M. (2001) Chromosomal imnbalances associated with response
to chemotherapy and cytotoxic cytokines in human malignant
glioma cell lines. Int. J. Cancer 91, 213-218
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*Knobbe, C.B., Lichter, P., *Reifenberger, G., *Weber, R.G.
(2002) Comprehensive analysis of genomic alterations in
gliosarcoma and its two tissue components. Genes Chromosom.
Cancer 34, 416-427
[24] *Brezniceanu, M.L., *Volp, K., *Bosse,S., *Solbach, C.,
Lichter, P., Joos, S., *Zörnig, M. (2003) HMGB1 inhibits cell death
in yeast and mammalian cells and is abundantly expressed in human
breast carcinoma. FASEB J. 17 (10), 1295-1297
Abteilung B060
Molekulare Genetik
DKFZ 2004: Wissenschaftlicher Ergebnisbericht 2002 - 2003
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Salowsky, R., Münstermann, E., Schick, M., Helmbach, H.,
Gschwendt, B., Korn, B., Kioschis, P., Lichter, P., Schadendorf, D.,
Poustka, A., (2002) Candidate genes for cross-resitance against
DNA damaging drugs. Cancer Research 62, 6698-6705
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Mincheva, A., Lichter, P., *Leder, G., *Gansauge, F., *Sorio, C.,
*Scarpa, A., *Gress, T.M. (2001) Loss of the Y chromosome is a
frequent chromosomal imbalance in pancreatic cancer and allows
differentiation to chronic pancreatitis. Int. J. Cancer 91, 340-344
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Lichter, P., *Kohrer, K. (2003) Comparative sequence and expression
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P., *Kruse, U., *Sippel, A.E. (2003) Genomic organization, splice
products and mouse chromosomal localization of genes for transcription
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Granzow, M., Conrad, C., Kalla, J., Lichter, P., Eils, R. (2001) A
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[30] *Wessendorf, S., Fritz, B., Wrobel, G., Nessling, M.,
Lampel, S., Goettel, D., Kuepper, M., Joos, S., *Hopman, T.,
Kokocinski, F., *Döhner, H., *Bentz, M., Schwaenen, C., Lichter,
P. (2002) Automated screening for genomic imbalances using matrix-based
comparative genomic hybridization (matrix-CGH). Lab.
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[31] *Wessendorf, S., Schwaenen, C., *Kohlhammer, H.,
Wrobel, G., *Barth, T., Nessling, M., *Möller, P., *Döhner, H.,
Lichter, P., *Bentz, M. (2003), Hidden gene amplification in aggressive
B-cell non-Hodgkin lymphoma detected by microarray
based comparative genomic hybridization. Oncogene 22, 1425-
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*Holzmann, K., *Kestler, H.A., *Kienle, D., *Barth, T.F.E.,
*Möller, P., *Ott, G., Kalla, J., Radlwimmer, B., Pscherer, A.,
*Stilgenbauer, S., *Döhner, H., Lichter, P., *Bentz, M. (2004) Genomic
DNA-chip hybridization in t(11:14)-positive mantle cell lymphomas
shows a high frequency of aberrations and allows a refined
characterization of consensus regions. Blood (in press)
[33] *Wessendorf, S., Lichter, P., Schwaenen, C., Fritz, B.,
Baudis, M., *Walenta, K., *Kloess M., *Döhner, H., *Bentz, M.
(2001) Potential of chromosomal and matrix-based comparative
genomic hybridization for molecular diagnostics in lymphomas.
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H., Lichter, P., *Bentz, M. (2003) DNA microarray analysis in malignant
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Genomforschung zur Verbesserung der Diagnostik von
Krebserkrankungen beitragen? Onkologie heute 3, 10-14
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leukemia: Development of a clinical tool and discovery of new recurrent
genomic alterations. Proc. Natl. Acad. Sci. USA 101,
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patterns in acute myeloid leukemia correlate with centrosome
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Oncogene 23, 2379-2384
[39] Fritz, B., Kokocinski, F., Schlingemann, J., Hahn, M. (2003)
Anwendungen der DNA-Chiptechnologie in der Krebsforschung.
BIOspektrum 9, 78-83