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MDCK-MRP2 - Dkfz

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214<br />

Forschungsschwerpunkt C<br />

Krebsrisikofaktoren und Krebsprävention<br />

[68] Korz C., Pscherer A., Benner A., Mertens D., Schaffner<br />

C., Leupolt E., Döhner H., Stilgenbauer S., Lichter P.: Evidence<br />

for distinct pathomechanisms in B-cell chronic lymphocytic leukemia<br />

and mantle cell lymphoma by quantitative expression analysis<br />

of cell cycle and apoptosis-associated genes. Blood 99 (12)<br />

4554-4561, 2002.<br />

[69] Kröber A., Seiler T., Benner A., Bullinger L., Brückle E.,<br />

Lichter P., Döhner H., Stilgenbauer S.: V(H) mutation status,<br />

CD38 expression level, genomic aberrations, and survival in<br />

chronic lymphocytic leukemia. Blood 100 (4) 1410-1416, 2002.<br />

[70] Kuntz C., Kienle P., Schmeding M., Benner A., Autschbach<br />

F., Schwalbach P.: Comparison of laparoscopic versus conventional<br />

technique in colonic and liver resection in a tumor-bearing<br />

small animal model. Surg.Endosc. 16 (8) 1175-1181, 2002.<br />

[71] Laack E., Mende T., Dürk H., Kneba M., Dickgreber N.,<br />

Welte T., Müller T., Scholtze J., Graeven U., Jasiewicz Y., Edler<br />

L., Hossfeld D.K.: Gemcitabine, vinorelbine and cisplatin combination<br />

chemotherapy in advanced non-small cell lung cancer: a<br />

phase II trial. Europ.J.Cancer 38 654-660, 2002.<br />

[72] Laack E., Nikbakht H., Peters A., Kugler C., Jasiewicz Y.,<br />

Edler L., Brümmer J., Schumacher U., Hossfeld D.K.: Expression<br />

of CEACAM1 in adenocarcinoma of the lung: a factor of independent<br />

prognostic significance. J.Clin.Oncol. 20 (21) 4279-4284,<br />

2002.<br />

[73] Laack E., Nikbakht H., Peters A., Kugler C., Jasiewicz Y.,<br />

Edler L., Hossfeld D.K., Schumacher U.: Lectin histochemistry of<br />

resected adenocarcinoma of the lung. Helix pomatia agglutinin<br />

binding is an independent prognostic factor. Am.J.Pathol. 160 (3)<br />

1001-1008, 2002.<br />

[74] Laufs S., Gentner B., Nagy K.Z., Jauch A., Benner A.,<br />

Naundorf S., Kühlcke K., Schiedlmeier B., Ho A.D., Zeller W.J.,<br />

Frühauf S.: Retroviral vector integration occurs into preferred<br />

genomic targets of human bone marrow repopulating cells. Blood<br />

101 (6) 2191-2198, 2003.<br />

[75] Leupolt E., Stilgenbauer S., Kröber A., Benner A., Lichter<br />

P., Döhner H.: Clonal evolution in B-CLL-association with IgVH homology,<br />

disease progression and in-vivo resistance to therapy.<br />

Onkol. 25(S4), p.172 (608), 2002.<br />

[76] Liebisch P., Erne S., Scheck D., Wellmann A., Einsele H.,<br />

Straka C., Goldschmidt H., Benner A., Stilgenbauer S., Döhner<br />

H.: In multiple myeloma, five common genomic aberrations (+1q,<br />

+9q, +11q, 13q-, t14q) display a non-random distribution and<br />

suggest novel pathogenetic pathways. Onkol. 26(S5), p.121<br />

(P684), 2003.<br />

[77] Liebisch P., Wellmann A., Wendl C., Roth K., Benner A.,<br />

Stilgenbauer S., Döhner H.: Trisomies of chromosomes 1q, 9q,<br />

and 11q in multiple myeloma - non-random distribution of three<br />

highly frequent aberrations. Onkol. 25(S4), pp.73-74 (252),<br />

2002.<br />

[78] Lutz W.K., Vamvakas S., Kopp-Schneider A., Schlatter J.,<br />

Stopper H.: Deviation from additivity in mixture toxicity: relevance<br />

of nonlinear dose-response relationships and cell line differences<br />

in genotoxicity assays with combinations of chemical<br />

mutagens and y-radiation. Environ.Hlth.Persp. 110 (Suppl.6)<br />

915-918, 2002.<br />

[79] Manegold C., Mezger J., Pilz L.R., Schott K., Koschel G.,<br />

Hruska D.: Single-agent gemcitabine and docetaxel given sequentially<br />

every 3 weeks in advanced NSCLC: final results of a<br />

randomized phase-II-study show effective treatment. Onkol.<br />

26(S5), p.140 (P753), 2003.<br />

[80] Manegold C., Pilz L., Koschel G., Schott K., Hruska D.,<br />

Mezger J.: Final results from two randomized phase II studies<br />

with single agent gemcitabine and docetaxel given sequentially in<br />

various doses and schedules are effective in advanced NSCLC.<br />

Proc.ASCO (No.1273), 2002.<br />

[81] Manegold C., Pilz L., Koschel G., Schott K., Hruska D.,<br />

Mezger J.: Survival data from two randomized phase II studies<br />

show effectiveness for therapy of advanced NSCLC by single<br />

agent gemcitabine and docetaxel given sequentially in various<br />

doses and schedules. J.Cancer Res.Clin.Oncol. 128(Suppl.1),<br />

p.74 (P376), 2002.<br />

C060<br />

Biostatistik<br />

DKFZ 2004: Wissenschaftlicher Ergebnisbericht 2002 - 2003<br />

[82] Markowetz F., Edler L., Vingron M.: Support vector machines<br />

for protein fold class prediction. Biometr.J. 45 (3) 377-<br />

389, 2003.<br />

[83] Möhler T., Hillengass J., Höpfner S., Benner A., Schlenzka<br />

J., Neben K., Egerer G., Görner M., Ho A.D., Goldschmidt H.:<br />

Thalidomide and CED chemotherapy followed by stem cell transplantation<br />

for poor prognosis multiple myeloma. Onkol. 26(S5),<br />

p.132 (P720), 2003.<br />

[84] Müller A., Drings P., Rittgen W., Manegold C.: CNS-relapse<br />

after multimodality treatment of stage III non-small cell<br />

lung cancer. J.Cancer Res.Clin.Oncol. 128(Suppl.1), p.76<br />

(P384), 2002.<br />

[85] Neben K., Korshunov A., Benner A., Wrobel G., Hahn M.,<br />

Golanov A., Lichter P.: Identification of novel prognostic markers<br />

in medulloblastoma by gene expression experiments. Onkol.<br />

26(S5), p.37 (V352), 2003.<br />

[86] Neben K., Korshunov A., Wrobel G., Tews B., Benner A.,<br />

Hahn M., Golanov A., Lichter P.: Gene expression patterns in<br />

ependymoma correlate with tumor location and patient age.<br />

Onkol. 26(S5), p.203 (P981), 2003.<br />

[87] Oberemm A., Querfurth N., Dieterich A., Meckert C.,<br />

Brandenburger L., Herzig A., Lindner Y., Krause E., Ittrich C.,<br />

Kopp-Schneider A., Richter-Reichhelm H.B., Gundert-Remy U.:<br />

Proteomic analysis of TCDD-mediated effects in marmoset liver<br />

and thymus. Naunyn-Schmiedeb.Arch.Pharmacol. 367(Suppl.1),<br />

p.R153 (599), 2003.<br />

[88] Oberemm A., Querfurth N., Meckert C., Brandenburger L.,<br />

Herzig A., Kalenberg K., Krause E., Ittrich C., Kopp-Schneider<br />

A., Hellmann J., Bannasch P., Richter-Reichhelm H.B., Gundert-<br />

Remy U.: Proteomic investigation into n-nitrosomorpholine mediated<br />

changes in rat liver. Toxicol.Lett. 144(Suppl.1), p.s103<br />

(379), 2003.<br />

[89] Öhm C., Ittrich C., Mezger J., Langenbuch T., Eckardt<br />

M.J., Lehban H., Rehm M., Schulz G., Seipelt G., Ehlert T., Stauch<br />

M., Wolters U., Edler L.: Gemcitabine and vindesin combination<br />

regimen in inoperable metastatic non-small cell lung cancer: a<br />

phase II study. Onkol. 26(S5), p.141 (P754), 2003.<br />

[90] Pauli T., Pilz L., Rittgen W.: A stochastic model of the<br />

human skin under consideration of cell proliferation and differentiation<br />

and its realization as a simulation model.<br />

Inf.Biom.Epidem.Med.Biol. 34(3), pp.309-311, 2003.<br />

[91] Renwick A.G., Barlow S.M., Hertz-Piccioto I., Boobis A.R.,<br />

Dybing E., Edler L., Eisenbrand G., Greig J.B., Kleiner J., Lambe<br />

J., Müller D.J.G., Smith M.R., Tritscher A., Tuijtelaars S., van den<br />

Brandt P., Walker R., Kroes R.: Risk characterization of chemicals<br />

in food and diet. Final part of Food Safety in Europe (FOSIE):<br />

Risk assessment of chemicals in food and diet (EC concerted action<br />

QLK1-1999-00156). Food Chem.Toxicol. 41 (9 special issue)<br />

1211-1271, 2003.<br />

[92] Salowsky R., Heiss N.S., Benner A., Wittig R., Poustka A.:<br />

Basal transcription activity of the dyskeratosis congenita gene is<br />

mediated by Sp1 and Sp3 and a patient mutation in a Sp1 binding<br />

site is associated with decreased promoter activity. Gene 293 (1-<br />

2) 9-19, 2002.<br />

[93] Schlenk R.F., Benner A., Hartmann F., del Valle F., Weber<br />

C., Pralle H., Fischer J., Gunzer U., Pezzutto A., Weber W.,<br />

Grimminger W., Preiss J., Hensel M., Fröhling S., Döhner K., Haas<br />

R., Döhner H.: Risk-adapted postremission therapy in acute myeloid<br />

leukemia: results of the German multicenter AML HD93<br />

treatment trial. Leukem. 17 (8) 1521-1528, 2003.<br />

[94] Schlenk R.F., Fröhling S., Benner A., Addamo B.,<br />

Hartmann F., del Valle F., Pralle H., Fischer J.T., Kölbel C.B.,<br />

Grimminger W., Mergenthaler H.G., Preiss J., Hensel M.,<br />

Glasmacher A., Peschel C., Waterhouse C., Salwender H.,<br />

Biedermann H.G., Kneba M., Kremers S., Koller E., Griesinger F.,<br />

Döhner K., Haas R.: Phase III- study of all-trans retinoic acid in<br />

previously untreated patients 61 years or older with acute myeloid<br />

leukemia: AMLSG ULM study HD98B. Onkol. 26(S5), p.1<br />

(V137), 2003.

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