MDCK-MRP2 - Dkfz

58
Forschungsschwerpunkt A
Zell- und Tumorbiologie
[8] Uemura, M.; Kojima, H.; Buchholz, U.; *Kikuchi, E.;
*Matsumoto, M.; *Kikukawa, M.; *Takaya, A.; *Fukui, H.;
*Tsujii, T.; Keppler, D.: Cysteinyl leukotrienes in the bile of patients
with obstructive jaundice. Journal of Gastroenterology 37
(2002) 821-830.
[9] Michalski, C.; Cui, Y.; Nies, A.T.; *Nuessler, A.K.; *Neuhaus,
P.; *Zanger, U.M.; *Klein, K.; *Eichelbaum, M.; Keppler, D.;
König, J.: A naturally occurring mutation in the SLC21A6 gene
causing impaired membrane localization of the hepatocyte uptake
transporter. Journal of Biological Chemistry 277 (2002) 43058-
43063.
[10] Nies, A.T.; König, J.; Keppler, D.: Zytostatika-Resistenz
durch Membranpumpen. TargetForum 2/02 (2002) 34-39.
[11] Keitel, V.; Nies, A.T.; Brom, M.; Hummel-Eisenbeiss, J.;
Spring, H.; Keppler, D.: A common Dubin-Johnson syndrome mutation
impairs protein maturation and transport activity of MRP2
(ABCC2). American Journal of Physiology - Gastrointestinal and
Liver Physiology 284 (2003) G165-G174.
[12] Cui, Y.; Walter, B.: Influence of albumin-binding on the substrate
transport mediated by human hepatocyte transporters
OATP2 and OATP8. Journal of Gastroenterology 38 (2003) 60-
68.
[13] Cui, Y.; König, J.; Nies, A.T.; Pfannschmidt, M.; Hergt, M.;
Franke, W.W.; Alt, W.; *Moll, R.; Keppler, D.: Detection of the
human organic anion transporters SLC21A8 (OATP2) and
SLC21A8 (OATP8) in liver and hepatocellular carcinoma. Laboratory
Investigation 83 (2003) 527-538.
[14] Rius, M.; Nies, A.T.; Hummel-Eisenbeiss, J.; Jedlitschky, G.;
Keppler, D.: Cotransport of reduced glutathione with bile salts by
MRP4 (ABCC4) localized to the basolateral hepatocyte membrane.
Hepatology 38 (2003) 374-384.
[15] Kojima, H.; Nies, A.T.; König, J.; Hagmann, W.; Spring, H.;
Uemura, M.; *Fukui, H.; Keppler, D.: Changes in the expression
and localization of hepatocellular transporters and radixin in primary
biliary cirrhosis. Journal of Hepatology 39 (2003) 693-702.
[16] Fehrenbach, T.; Cui, Y.; *Faulstich, H.; Keppler, D.: Characterization
of the transport of the bicyclic peptide phalloidin by human
hepatic transport proteins. Naunyn-Schmiedeberg’s Archives
of Pharmacology 368 (2003) 415-420.
[17] König, J.; Nies, A.T.; Cui, Y.; Keppler, D.: MRP2, the apical
export pump for anionic conjugates. In: ABC Proteins: From Bacteria
to Man. Eds.: I.B. Holland et al. London: Academic Press
(2003) 423-443.
[18] König, J.; Michalski, C.; Cui, Y.; Nies, A.T.; *Nuessler, A.K.;
*Neuhaus, P.; *Zanger, U.M.; *Klein, K.; *Eichelbaum, M.;
Keppler, D.: Mutations in the sodium-independent bile salt transporter
of human liver, SLC21A6. In: Bile Acids: From Genomics to
Disease and Therapy. Eds.: G. Paumgartner et al. Dordrecht:
Kluwer Academic Publishers (2003) 83-88.
[19] Kojima, H,; Nies, A.T.; König, J.; Uemura, M.; *Fukui, H.;
Keppler, D.: Expression and localization of hepatocellular transporters
and radixin in primary biliary cirrhosis. In: Bile Acids: From
Genomics to Disease and Therapy. Eds.: G. Paumgartner et al.
Dordrecht: Kluwer Academic Publishers (2003) 199-205.
[20] Nies, A.T.; Cui, Y.; König, D.; Keppler, D.: Transport of bilirubin
conjugates across hepatocellular membrane domains and
the conjugated hyperbilirubinemia of Dubin-Johnson syndrome.
In: Molecular Pathogenesis of Cholestasis. (Eds. M. Trauner, P.
Jansen). Georgetown / New York: Landes Bioscience / Kluwer
Acad. Publishers (2003) 195-210.
Abteilung A090
Tumorbiochemie
DKFZ 2004: Wissenschaftlicher Ergebnisbericht 2002 - 2003