MDCK-MRP2 - Dkfz

380
Forschungsschwerpunkt F
Infektion und Krebs
[7] Poirey, R., *Despons, L., *Leh, V., *Lafuente, M.J., *Potier,
S., *Souciet, J.L. and Jauniaux, J.C. (2002) Functional analysis
of the Saccharomyces cerevisiae DUP240 multigene family reveals
membrane-associated proteins that are not essential for
cell viability. Microbiology 148, 2111-2123.
[8] *Marchini, A., *Accardi, R., *Malanchi, I., *Schyr, E.,
*Oxelmark, E., *De Pinto, V., Jauniaux, J.C., *Maundrell, K. and
*Tommasino, M. (2002) Schizosaccharomyces pombe Pmf1p is a
mitochondrial protein and is structurally and functionally related
to Mmf1p of Saccharomyces cerevisiae. Yeast 19, 703-711.
[9] *Lefebvre, L., *Vanderplasschen, A., *Ciminale, V.,
*Heremans, H., *Dangoisse, O., Jauniaux, J.C., *Toussaint, JF.,
*Zelnik, V., *Burny, A., *Kettmann, R. and *Willems, L. (2002)
Oncoviral bovine leukemia virus G4 and human T-cell leukemia virus
type 1 p13 (II) accessory proteins interact with farnesyl pyrophosphate
synthetase. Journal of Virology 76, 1400-1414.
[10] *Piontek, J., Régnier-Vigouroux, A. and *Brandt, R. (2002)
Contact with astroglial membranes induces axonal and dendritic
growth of human CNS model neurons and affects the distribution
of the growth associated proteins MAP1B and GAP43. Journal of
Neuroscience Research 67, 471-483.
[11] *Weber-Lotfi, F., *Guillemaut, P., Poirey, R., *Schmitz, M.
and *Dietrich, A. (2002) Biochemical and molecular studies on declining
and decline-resistant spruce in the North-East of France.
Environmental Science and Pollution Research International 9,
122-129.
[12] Salomé, N. and Grimm, D. (2002) Gene therapy with
parvoviruses? How viruses can be modified to turn into tools
against cancer. In: Current Cancer Research. Stamatiadis-Smidt
H., ed. Steinkopff Darmstadt-Springer New York, pp.155-160.
[13] Salomé, N. and Grimm, D. (2002) Gentherapie mit
Parvoviren? In: Krebsforschung heute. Stamatiadis-Smidt H., ed.
Steinkopff Darmstadt-Springer New York, pp. 168-173.
[14] Rommelaere, J., *Almendral, J.M., Cornelis, J.J. and
Nüesch, J.P.F. (2002) Parvovirus. In: The Springer Index of Viruses.
Tidona, C.A. and Darai, G., eds. Springer Verlag Heidelberg,
pp. 713-722.
[15] Lachmann, S., Rommelaere, J. and Nüesch, J.P.F. (2003)
Novel PKCγ is required to activate replicative functions of the
major non-structural protein NS1 of minute virus of mice. Journal
of Virology 77, 8048-8060.
[16] *Moehler, M., *Zeidler, M., *Schede, J., Rommelaere, J.,
*Galle, P.R., Cornelis, J.J. and *Heike, M. (2003) Oncolytic
parvovirus H1 induces release of heat-shock protein HSP72 in
susceptible human tumor cells but may not affect primary immune
cells. Cancer Gene Therapy 10, 477-480.
[17] Nüesch, J.P.F., Lachmann, S., Corbau, R. and Rommelaere,
J. (2003) Regulation of MVM NS1 replicative functions by atypical
PKCd in vivo. Journal of Virology 77, 433-442.
[18] *Malerba, M., Daeffler, L., Rommelaere, J. and *Iggo, R.D.
(2003) Replicating parvoviruses which target colon cancer cells.
Journal of Virology 77, 6683-6691.
[19] Wrzesinski, C., Tesfay, L., Salomé, N., Jauniaux, J.C.,
Rommelaere, J., Cornelis, J. and Dinsart, C. (2003) Chimeric and
pseudotyped parvoviruses minimize the contamination of recombinant
stocks with replication-competent viruses and identify a
DNA sequence that restricts parvovirus H-1 in mouse cells. Journal
of Virology 77, 3851-3858.
[20] Zimmer, H., *Riese, S. and Régnier-Vigouroux, A. (2003)
Functional characterization of mannose receptor expressed by
immunocompetent mouse microglia. Glia 42, 89-100.
[21] Régnier-Vigouroux, A. (2003) The mannose receptor in the
brain. International Review of Cytology 226, 321-342.
[22] Daeffler, L., Hörlein, R., Rommelaere, J. and Nüesch, J.P.F.
(2003) Modulation of minute virus of mice cytotoxic activities
through site-directed mutagenesis within the NS coding region.
Journal of Virology 77, 12466-12478.
[23] Cziepluch, C., Schlehofer, J.R. and *Veldwijk, M.R. (2003)
Parvoviren in der Krebs- und Gentherapie. In: “Onkologie”. Zeller,
W.J. and zur Hausen, H. eds. Ecomed Verlag Landsberg/Lech,
Losbl.-Ausg. IV-21.2, pp. 1-28
Abteilung F010
Tumorvirologie
[24] Cornelis, J.J., Lang, S., Stroh-Dege, A.Y., Balboni, G.,
Dinsart, C. and Rommelaere, J. (2004) Cancer therapy through
autonomous parvovirus-mediated gene transfer. Current Gene
Therapy, 4, 249-261.
[25] *Twizere, J.C., *Kruys, V., *Lefebvre, L.,
*Vanderplasschen, A., *Collete, D., *Debacq, C., *Lai, W.S.,
Jauniaux, J.C., *Bernstein, L., *Semmes, O.J., *Burny, A.,
*Blackshear, P.J., *Kettmann, R. and *Willems, L. (2004) Tax
oncoproteins interact with tristetraprolin and regulate TNF-alpha
expression. Journal of National Cancer, in press.
[26] Cornelis, J.J., Salomé, N., Dinsart, C. and Rommelaere, J.
(2004) Vectors based on autonomous parvoviruses: novel tools
to treat cancer? Journal of Gene Medicine, 6, suppl. 1, 193-204.
[27] Raykov, Z., Balboni, G., *Aprahamian, M. and Rommelaere,
J. (2004) Carrier cell-mediated delivery of oncolytic parvoviruses
for targeting metastasis. International Journal of Cancer, 109,
742-749.
[28] Winnefeld, M., Rommelaere, J. and Cziepluch, C. (2004)
The human small glutamine-rich TPR-containing protein (hSGT) is
required for progress through cell division. Experimental Cell Research
293, 43-57.
[29] Rommelaere, J., Giese, N., Cziepluch, C. and Cornelis, J.J.
(2004) Parvoviruses as anti-cancer agents. In: “Virus Therapy of
Human Cancers” Sinkovics, J.G. and Horvath, J.C., eds. Marcel
Dekker, Inc. in press.
[30] Herrero y Calle, M., Cornelis, J.J., Herold-Mende, C.,
Rommelaere, J., Schlehofer, J.R. and Geletneky, K. (2004)
Parvovirus H-1 infection of human glioma cells leads to complete
viral replication and efficient cell killing. International Journal of
Cancer 109, 76-84
[31] Enderlin, M., *Struyf, S., *Van Damme, J., *Sozzani, S.,
*Vecchi, A., Rommelaere, J., Cornelis, J. and Dinsart, C. Combined
expression of TNFα and IP.10 by means of parvoviruses
induces regression of tumors derived from glioma cells implanted
s.c. in mice. Journal of Gene Medicine (in press)
Patentanmeldungen
Nüesch, J.P.F. and Rommelaere, J. (2003) Fusion polypeptide
suitable as a cytotoxin Application 03 009 952.7 (Eur)
Rommelaere, J., Cornelis, J., Dinsart, C., Schlehofer, J.R.,
Geletneky, K. and Herrero, Y. Calle, M. (2003) Use of parvovirus
for brain tumor therapy Application 10/426.709 (USA)
Cziepluch, C., Rommelaere, J. and Winnefeld, M. (2003) Method
to inhibit the propagation of an undesired cell population Application
03 018 451.9 (Eur)
Hochschulschriften
C. Wrzesinski: Autonome Parvoviren. Entwicklung einer zweiten
Generation von Vektoren für die Tumor-Gentherapie und
Untersuchung des Einflusses der Infektion auf die zelluläre
Genexpression. Dissertation, Tierärztliche Fakultät der Ludwig-
Maximilians-Universität München (2002)
H. Zimmer: Untersuchungen von Mikrogliazellen und des Mannose-Rezeptors
unter einem immunologischen Blickwinkel. Dissertation,
Naturwissenschaftlich-Mathematische Gesamtfakultät,
Universität Heidelberg (2002)
Z. Raykov: Gene transduction by means of parvoviral and chimeric
adenoviral vectors for cancer therapy. Dissertation,
Medizinische Fakultät, Universität Heidelberg (2002)
X. Apsi: Funktion des SGT/NS1-Komplexes im Lebenszyklus
autonomer Parvoviren. Dissertation, Naturwissenschaftlich-
Mathematische Gesamtfakultät, Universität Heidelberg (2002)
J. Li: Antineoplastic activity of autonomous parvovirus H1: identification
of cellular genes differentially expressed in the hepatocellular
carcinoma cell line QGY-7703 after parvovirus H1 infection.
Dissertation, Joint supervision of the Universities of Louis
Pasteur, Strasbourg 1, France, and Fudan of Shanghai, People
Republic of China (2002)
L. Tesfay: Production and efficacy of recombinant parvoviruses
to deliver the isoforms of MIP-1α chemokine in brain tumour cells.
Diplom, Department of Biotechnology, Mannheim University of
applied Sciences (2002)
DKFZ 2004: Wissenschaftlicher Ergebnisbericht 2002 - 2003