Psychische Erkrankungen in der Lebensspanne ... - DGPPN

Topic 3 G Psychotische Störungen, F2 // Psychotic disorders, F2
and Negative Syndrome Scale (PANSS), Clinical Global Impression-Severity
Scale (CGI-S), patient satisfaction, adverse events
(AEs), extrapyramidal symptoms (Extrapyramidal Symptom Rating
Scale; ESRS) and weight change.
Discussion / Results: 81 patients were included (52 % female, mean
age 39.8 ± 12.9 years, 74 % paranoid schizophrenia). 84 % of the
patients completed the 6-month study. Reasons for early discontinuation
were lack of efficacy (8.6 %), lack of efficacy plus AE (3.7 %),
loss to follow-up, patient choice and AE (1.2 % each). The median
mode dose of paliperidone ER was 6 mg/day. 64.2 % of patients had
a ≥20 % improvement in total PANSS at endpoint. Mean total
PANSS decreased statistically significantly from 82.7 ± 18.1 at baseline
to 70.9 ± 25.4 at endpoint (mean change -11.8 ± 19.6; 95 %
confidence interval -16.1;-7.5, p