Abstracts Book - IMRC 2018

• SB5-O006 Invited Talk
MOLECULARLY IMPRINTED POLYMER MODIFIED CdTeS/ZnS QDs
FOR THE RECOGNITION OF DOPAMINE
Raphael Schneider 1
1 Université de Lorraine, LRGP, France.
Dopamine is one of the most important neurotransmitters and is essential for
the normal functions of the central nervous system. Detection and
quantification of dopamine is important in diagnoses, monitoring, prevention
and treatments of several diseases such as schizophrenia, HIV infections, or
Parkinson. Incorporation of quantum dots (QDs) into molecularly imprinted
polymers (MPIs) allows the development of sensor materials with high selectivity
for the template. In this work, nanocomposites composed of core/shell
CdTeS/ZnS QDs and poly(acrylamide) cross-linked with ethylene glycol
dimethylacrylate were prepared for the sensing of dopamine. The fluorescence
intensity of CdTeS/ZnS QDs@MIP composites is quenched within 2 min upon
binding dopamine while that of the non-imprinted polymer capped QDs
remains unaffected. The fluorescence quenching is best described by a Stern-
Volmer type equation and exhibits a good linearity with dopamine
concentration. The fluorescence quenching mechanism, originating from
electron transfers between dopamine and QDs, will also be discussed. The limit
of detection could reach 7 nM indicating that the sensor is highly sensitive for
the detection of dopamine. The sensor was also demonstrated to be weakly
sensitive to other molecules (aminoacids, peptides, proteins, vitamins and other
neurotransmitters) and ions. Finally, the WST-1 results demonstrate that the
CdTeS/ZnS@MIP nanocomposite is of low cytotoxicity and thus of high potential
for the development of efficient dopamine diagnostic tests.
Keywords: quantum dots, MIP, dopamine
Presenting authors email: raphael.schneider@univ-lorraine.fr