Abstracts Book - IMRC 2018

• SB6-P102
COENCAPSULATION OF FE3O4 NANOPARTICLES AND
ANTITUMORAL PEPTIDES ON PLGA NANOCAPSULES
Yuniel Gerardo Rodríguez Rivero 1 , Hernani T Yee 2
1 Escuela Superior de Física y Matemáticas IPN, Laboratorio de Espectroscopia Mossbauer y
Técnicas complementarias, Mexico. 2 Escuela Superior de Física y Matemáticas IPN, Laboratorio
de Espectroscopia Mosbauer y Técnicas complementarias, Mexico.
Pharmacokinetic mechanism of conventional drugs in cancer therapy comprises
the steps of drug administration, body distribution, absorption and final
excretion in a relatively short time period. This fact leads to the necessity of
applying prolonged therapies with risks of active principles accumulation in
organs, appearance of systemic side effects and fluctuation of the blood drug
levels. In this way, encapsulation of therapeutic peptides in degradable capsules
of polylactic-co-glycolic acid polymer (PLGA), allows sustained release of the
drug and offers protection against the enzymatic barrier of the organism.
However, these systems must be vectorized to avoid the systemic effects caused
by antitumor treatments. In this field, the magnetite nanoparticles (Fe3O4)
constitute a vectoring agent with many additional applications, which includes
its capacity as contrast agents on Magnetic Resonance Imaging (MRI) for cancer
diagnosis.
The main goal of this work was to design and obtain systems that combine the
potentials of controlled drug release systems in the treatment of tumors
together with the contrasting and magnetic orientation capabilities of magnetite
nanoparticles. In that direction, we have obtained composites capsules of PLGA
loaded with antitumoral peptides and magnetite nanoparticles of 200 nm on
average. The morphology of the nanocapsules has been determined by electron
microscopy techniques (SEM and TEM). Also, the chemical structure of the
composite has been studied by several techniques as XRD, TGA and FT-IR. The
system obtained has shown magnetic response that suggest it can be apply in
the area of nanomedicine.
Keywords: magnetite nanoparticles, PLGA, Control release systems
Presenting authors email: yrrivero90@gmail.com