Abstracts Book - IMRC 2018

• SB1-O025 Invited Talk
TELODENDRIMERS BASED NANOSTRUCTURES FOR DRUG
DELIVERY: A HYBRID PLATFORM COMBINING ADVANTAGEOUS
TRAITS OF LINEAR POLYMERS WITH DENDRIMERS
Ashok Kakkar 1
1 McGill University, Chemistry, Canada.
Macromolecules based therapeutics (nanomedicine) continues to evolve linear
block-copolymers to branched (miktoarm polymers) and hyperbranched
(dendrimers) architectures. It is becoming increasing clear that combining
important characteristics of linear polymers with those of branched and
hyperbranched architectures could yield hybrid structures (telodendrimers) that
could help address key issues in nanomedicine. Despite tremendous potential,
significant challenges related to simplifying their synthetic schemes,
understanding their self-assembly behavior, and enabling them to multi-task,
still remain. An important parameter for constructing these scaffolds is to
develop synthetic tools that can provide desired spatial distribution of different
components in these nanostructures. The methodologies need to be simple and
highly versatile, and adaptable to the needs of biology. We shall describe how
chemical innovation can provide easy access to a variety of telodendrimers, and
their self-assembly could be tuned with varied compositions. Such functional
nanostructures can be used for monotherapy through physical encapsulation
or drug conjugation, or combination therapy using multiple drugs. Their
structural complexity is ideally suited to adapt to the needs of ever-increasing
complexity of high morbidity rate diseases and facilitate drug delivery at specific
disease sites.
Acknowledgment:
We would like to thank Natural Sciences and Engineering Council of Canada
and Quebec Centre for Advanced Materials (QCAM) for financial support.
Keywords: Telodendrimers, Nanomedicine, Drug Delivery
Presenting authors email: ashok.kakkar@mcgill.ca