Abstracts Book - IMRC 2018

• SB6-P018
WEAR EFFECT ON THE REALESE OF ANTIBIOTIC IN PMMA CEMENT
Rocio Guadalupe Hernandez Garcia 1
1
Universidad Autónoma de Nuevo León, Facultad de Ingenieria Mecanica y Electrica, Mexico.
This investigation was based on determining how wear affects a temporary hip
prosthesis, in which the head of the femur is made with polymethyl
methacrylate (PMMA) and gentamicin, and how it favors the organic matter of
the bone in the performance of the piece.
During the polymerization reaction of the PMMA the oxygen present in the
environment creates a porosity in the piece, which favor the release of the
antibiotic, however, these pores can be eliminated due to the friction to which
the piece is subjected (head of femur versus acetabulum), due to this, we sought
to establish the kinetics of gentamicin release, through a wear test in a hip
simulator using bovine serum as a lubricant, the concentration of gentamicin
was quantified by Uv-Vis spectrophotometry.
Subsequently, PMMA pins and porcine cortical bone discs were created to
perform a tribology test in pin on discfollowing the protocol of ASTM G99-17 and
determine the influence of organic matter in PMMA, performing optical
microscopy before and after of the wear test to the piece.
The results obtained show that if there is a relationship between the porosity
and the release of the drug, however in the prosthesis there is no significant
alteration in the kinetics of release, in addition it is verified as the lubrication
generated by the collagen present in the bone increases the performance of the
piece.
Acknowledgment:
We appreciate the support provided, economic, facilities and equipment, as well
as the advice provided, Universidad Autonoma de Nuevo Leon (UANL), Facultad
de Ingenieria Mecanica y Electrica (FIME), y al Consejo Nacional de Ciencia y
tecnologia ( CONACyT)
Keywords: Prosthesis, Wear, Polymethyl methacrylate
Presenting authors email: rocio_0426@live.com.mx