Abstracts Book - IMRC 2018

• SWMC-O002 Invited Talk
IMPROVED BIOCOMPATIBILITY OF 2D NANOMATERIALS BY
SURFACE MODIFICATION
Guibin Jiang 1
1 Research Center for Eco-Environmental Sciences of CAS, , China.
Two dimensional (2D) nanomaterials display excellent properties for application
in a vast wide of field. As a novel 2D nanomaterials, black phosphorus
nanosheets (BPs) showed promising potential in therapeutics, imaging and drug
delivery. BPs has been already demonstrated as a good nanomaterial in cancer
phototherapies and control release of drugs. However, the introduction of BPs
into the body might induced side-effects due to the possible small size and the
high activity because of the high ratio in surface area. Till now, the data on the
safety of BPs is extremely lack, which limits the wide application of this materials.
We here investigated the toxicity of BPs on mammal with mouse as a model. We
have demonstrated that bare BPs could stimulate the inflammation upon
intravenous injection. We compared the toxicity of bare BPs and titanium
modified BPs (TiL4@BPs). Our results demonstrated that titanium ligand could
protect BPs oxidation and TiL4@BPs exhibited no such adverse immune
responses. We then investigated the mechanisms of bare BPs underlying the
inflammatory effects. Our results indicated that the detailed investigation on the
biological effects of BPs with different modification is useful for their application
with low risks. We reported an efficient method to reduce the toxicity of bare
BPs.
Keywords: Nanomaterials, two dimensional, Black phosphorus
Presenting authors email: gbjiang@rceesa.ac.cn