Abstracts Book - IMRC 2018

• SB6-P051
MATHEMATICAL MODELING OF DISTRIBUTION OF MAGNETIC
NANOPARTICLES IMMERSED IN POLYMERS FOR POSSIBLE
TREATMENT OF HEPATIC TUMORS.
Tatiana Ivanova Román Valenzuela 1 , Ángel Luis Rodríguez Morales 1 , Miriam Rocío Estévez
González 1 , Ángel Ramón Hernández Martínez 1
1 Universidad Nacional Autónoma de México, Centro de Física Aplicada y Tecnología Avanzada,
Mexico.
We present a mathematical model of the distribution of magnetic nanoparticles
immersed in a polymeric compound sensitive to temperature, it purpose is to
release in a controlled manner an anthracycline (Doxorubicin) for a possible
treatment of liver cancer. The physiological premise indicates that when there is
a cancerous lesion, in some cases an angiogenic process is activated, that due
to the metabolism processes increases the local temperature, making viable the
release of the anthracycline. It is important to know the way in which the
nanoparticles, in a range of 30 to 50 nm, are distributed within the polymeric
matrix, and due to the characteristic of the radiopacity of the iron nanoparticles
it is possible to determine its distribution by X-rays images, the function is to
indicate the positioning in the space of the polymeric compound using X-
rays. The mathematical model obtained by digital image processing indicates
the probability for releasing the drug in the desired area, for a determined time,
in this way it is possible to reduce the collateral damage induced by the cytotoxic
material. This polymeric material is constituted by a hydrogel synthesized by the
polymerization of the monomers N,N-dimethylacrylamide (DMA) and N-
vinylcaprolactam (VCL). By making variations in molar ratio, reaction times and
percentages of crosslinking, hydrogels with different physical properties affect
the way in which the iron oxide (magnetite) nanoparticles are distributed, and
their times of degradation in saline solution.
Keywords: Hydrogel, Anthracycline, Radiopacity
Presenting authors email: tatiana.roman.valenzuela@gmail.com