Abstracts Book - IMRC 2018

• SB6-P044
SYNTHESIS OF LAYERED DOUBLE HYDROXIDE-CARBON DOT
COMPOSITE FOR IMAGING AND TARGETED CANCER THERAPY
Karina Nava Andrade 1 , Gregorio Guadalupe Carbajal Arizaga 1
1 Universidad de Guadalajara, Química, Mexico.
Cancer is the second leading cause of death worldwide and its incidence and
mortality rates have increased in recent years. Layered double hydroxides
(LDH), are nanotechnological innovations that can allow the development of
more effective anticancer treatments. These nanomaterials, also known as
hydrotalcite like compounds are well known for their good biocompatibility,
anion exchange capacity, pH-sensitivity and high chemical stability, therefore
they have been proposed to design smart drug delivery systems. Assemblies of
LDH with other nanoparticles would produce drug delivery vehicles with
targeted and controlled drug release. Particularly, carbon dots (CDs) have
attracted significant attention due to their photoluminescence properties,
chemical inertness, high water solubility, low toxicity, as well as easy and lowcost
synthesis. These relatively new nanomaterials promise many applications
in the fields of biosensing, bioimaging and nanomedicine. Recently, preparation
of CDs using folic acid (FA) has been studied as promising photoluminescent
probe for selective imaging of folate receptor-positive cancerous cells normal
cells. In this work, we describe intercalation of 5-fluorouracil (5-FU), a
chemotherapy drug used to treat different cancers, into the interlayer gallery of
LDH ZnAl, followed by surface adsorption of CDs prepared with FA. The
nanocomposite was characterized by XRD, SEM, and IR, XPS, and UV-visible
spectroscopies.
Acknowledgment:
K. N. A. thanks CONACyT scholarship. Financial support is acknowledged
CONACyT through the project 256690 (Fondo Sectorial de Investigación para la
Educación)
Keywords: Layered double hydroxide, Carbon dots, Targeting
Presenting authors email: karinajeruco@hotmail.com