Abstracts Book - IMRC 2018

• SB6-P105
PREPARATION OF SUB-50 NM STRUCTURES OF METHACRYLIC
COPOLYMER/ASPIRIN BY MEANS OF SEMICONTINUOUS
HETEROPHASE POLYMERIZATION WITH A HIGH DRUG CONTENT
Francisco Javier Enriquez 1 , Jose Roberto López 1 , Graciela Morales 1 , Raul Guillermo López 2 ,
Hened Saade Caballero 2
1 Centro de Investigación en Química Aplicada - CIQA , Síntesis de Polímeros, Mexico. 2 Centro
de Investigación en Química Aplicada - CIQA , Procesos de Polimerizacion, Mexico.
Drugs-loaded nanostructures offer several advantages
over actives administrated by conventional ways for reaching better
biopharmacological profiles, for example; promotion of the drug transit through
the different physiological body barriers, controlled release of the drug, higher
selectivity, longer periods of permanence in the blood, protection against
enzymatic degradation, among others. Different kind of nanostructures such as
liposomes, micelles and metallic nanoparticles have been tested for loading and
releasing of countless drugs, however, the use of polymeric nanoparticles (PNP)
have gained importance for these purposes because they offer features related
to greater stability and loading capacity, less toxicity, better control on the drug
release by the possibility to modulate the polymeric chain-lengths and the
crosslinking degree, etc. It is known that, kidneys filter the nanostructures lower
than 10 nm, also that the probability of nanostructures elimination by hepatic
way or by the spleen increases in nanostructures greater than 100 nm. Thus,
considering these and other factors it can be mentioned that drug-loaded
nanostructures with sizes varying between 10 and 50 nm are wanted/preferred
in the development and study of PNP/drugs systems. In these sense, the
Semicontinuous Heterophase Polymerization (SHP, patented by López
Campos et al.) offers the possibility to obtain PNP in the desired size range.
Aspirin-loaded PNP systems with sizes below 50 nm have not been reported in
the literature, thus, in this work it will be presented and discussed
polymerization details for obtaining PNP of poly(methyl methacrylate-comethacrylic
acid) by SHP stabilized in a relative high solids content latex (around
11%), with a composition methyl methacrylate/methacrylic acidmolar ratio
equal to 2/1 (components and composition of the commercial Eudragit S100
widely used as excipient), a number average molecular weight around 400
Kg/mol and an average particle size around 10 nm. It will be also discussed
procedures details for obtaining the aspirin-loaded PNP systems with the
desired average particle sizes and with high drug content, studying different