Abstracts Book - IMRC 2018

• SB2-O023
CORE-SHELL AND HOLLOW-SPHERE PARTICLES FROM
EUMELANIN VIA ENZYMATIC IN SITU COATING
Oliver Strube 1
1 Universität Paderborn, Biobased & Bioinspired Materials, Germany.
Eumelanin is a highly promising material for manifold applications including lifesciences.
Its most outstanding properties are free radical scavenging,
paramagnetism, radiation protection or hybrid electrical conductivity, combined
with high biocompatibility. Melanin-like materials can be made by manifold
ways of action. However, the optimal properties are gained if the resulting
material is a close to the natural archetype as possible. This can be assured by
enzymatic synthesis and strict parameter control. Major challenges of this
biomimetic approach, are to gain control over particle type and size, and to
incorporate the eumelanin into hybrid materials. Via the novel process of
Enzyme Mediated Autodeposition (EMA), defined layers of eumelanin can be
produced in situ around various submicro- and nano-particles, resulting in a
respective shell. Key aspect of EMA is an enzymatic reaction in direct proximity
to the support surface. This induces site-specific deposition of melanin on the
particle surfaces. With this approach it is possible to synthesize core–shell
particles with defined properties, which can afterwards be turned into hollow
particles as well. By this the desirable properties of biomimetic eumelanin can
be applied to user defined geometries, and applied in may areas of life-sciences;
from drug delivery or radiation therapy drugs to bio-electrical devices.
References:
[1] O. I. Strube, A. Büngeler, W. Bremser, Biomacromolecules 2015, 16, 1608–
1613.
[2] O. I. Strube, A. Büngeler, W. Bremser, Macromol. Mater. Eng. 2016, 301,
801–804.
[3] A. Büngeler, B. Hämisch, O. I. Strube, Int. J. Mol. Sci. 2017, 18.
[4] A. Büngeler, B. Hämisch, K. Huber, W. Bremser, O. I. Strube, Langmuir 2017,
33, 6895-6901.
Keywords: Melanin, Enzymes, Nanoparticles
Presenting authors email: oliver.strube@upb.de