Abstracts Book - IMRC 2018

• SB6-P057
PREPARATION AND CHARACTERIZATION OF AMPHIPHILIC
COPOLYMERS BLENDED POLY (LACTIC ACID) MEMBRANES FOR
DIALYSIS AND PROTEIN ADSORPTION
Cynthia Xix 1 , Arelly Varguez 1 , Manuel Aguilar 1 , María González 2
1 Centro de Investigación Científica de Yucatán, Unidad de Materiales, Mexico. 2 CONACyT,
Centro de Investigación Científica de Yucatán (CICY), Unidad de Materiales, Mexico.
Over the years, polymeric membranes for dialysis treatment have received
significant attention as an alternative therapy for patients with severe renal
disease. Synthetic polymers such as polyether sulfone (PES), polysulfone (PSF),
polymethylmethacrylate (PMMA) and polyacrylonitrile (PAN) have been
investigated as dialysis membrane materials [1]. Recently, hemodialysis
membranes biodegradable and renewable thermoplastic poly (lactic acid) (PLA)
have been development [2]. However, PLA membranes present hydrophobicity
and biofouling properties, which tends to inhibit their effectiveness. The
introduction of certain hydrophilicity degree resulting in an improved
antifouling capacity while maintaining their biocompatibility performance. In
this work, we used the blending approach to prepare PLA membranes with
different concentrations of amphiphilic copolymers polymethylmethacrylate-bpoly(2-hydroxyethyl
methacrylate) (PMMA-b-PHEMA) and
polymethylmethacrylate-co-poly(2-acryloamido-2-1-propanesulfonic acid)
(PMMA-PAMPS) as additives to enhance the antifouling and biocompatibility
performance of the membranes. Copolymers PMMA-b-PHEMA and PMMA-
PAMPS were synthesized by atom transfer radical polymerization (ATRP) and
free radical polymerization, respectively, and the membranes were elaborated
by nonsolvent induced phase separation technique. The chemistry and
membrane surface were characterized with 1 H-NMR and SEM. The membranes
exhibited an antifouling capacity between 60 and 65% with fluxes of 2.83-3.77
L/m 2 h (1 g/L BSA solution) under 0.4 psi of pressure. We also report the dialysis
results in comparison to pure PLA membrane.
Reference:
[1] L. Zhu, F. Liu, X. Yu, and L. Xue, ACS Appl. Mater. Interfaces, vol. 7, no. 32,
pp. 17748–17755, 2015.