Abstracts Book - IMRC 2018

• SB1-O024 Invited Talk
DENDRITIC Β-CYCLODEXTRIN DERIVATIVES AS CONTAINERS OF
HYDROPHOBIC GUESTS. STRUCTURAL ANALYSIS AND ITS IMPACT
IN THE PHARMACEUTICAL DESIRABILITY
Luis José López Méndez 1 , Yareli Rojas Aguirre 1 , Hugo Vázquez Lima 2 , Patricia Guadarrama 1
1 Universidad Nacional Autónoma de México, Polymers, Mexico. 2 Universidad Autónoma
Metropolitana, División de Ciencias Naturales e Ingeniería, Mexico.
Among the physicochemical properties for compounds with pharmaceutical
potential, the solubility and the permeability are the most important ones and
should have a desirable status. An acceptable condition of these properties is
associated with adequate absorption, distribution, metabolism and excretion,
as long as the compound does not exceed the toxicity allowed to reach the
phase I of clinical trials in humans. In the search for drugs with real
pharmaceutical potential, it is considered that the aforementioned properties
are equal, or even more important than the optimization of interactions with
biological receptors.
Various physicochemical descriptors, like logP (logarithm of the partition
coefficient between water and 1-octanol, related to the permeability), have been
proposed to discriminate and molecules with potential application in the
pharmaceutical industry, however, all of them apply to molecules of low
molecular weight, and limited analysis have done about macromolecular
systems.
Taking as starting point the progress in the cyclodextrins chemistry, in this work
was carried out the synthesis of monodisperse dendritic derivatives of βCD,
where systematic structural modifications were made and their effect on
properties like solubility and permeability was analyzed. The results allow
establishing some preliminary rules of discrimination for macromolecular
systems, and place these materials as very attractive ones for further
applications in the formulation and drug delivery fields.
Keywords: Cyclodextrins, Dendrimers, Encapsulation
Presenting authors email: patriciagua@iim.unam.mx