Abstracts Book - IMRC 2018

• SB6-P098
STUDY OF THE ELECTROCHEMICAL PROPERTIES OF THE LIGANDS
L24, PC, PO AND THEIR CORRESPONDING COPPER COMPLEXES
WITH POTENTIAL BIOMIMETIC ACTIVITY OF ANTIOXIDANT
ENZYMES BY CYCLIC VOLTAMMETRY.
Elio Alberto Molina Martinez 1 , Rocío Sugich Miranda 2 , Felipe Medrano Valenzuela 2 , Hisila
Santacruz Ortega 1 , Alex J. Salazar Medina 1
1 Universidad de Sonora, Departamento de Investigación en Polímeros y Materiales, Mexico.
2 Universidad de Sonora, Departamento de Ciencias Químico Biológicas, Mexico.
The coordination complex of macrocycles with transition metals are currently
considered a promising alternative, which could be supported in the treatment
or prevention of various diseases, as well as helping the understanding of
biological systems (model systems). Previous research has suggested that some
of these complexes have characteristics of biomimetic agents with antioxidant
capacity, this is of great interest due to the wide range of diseases caused by
oxidative stress, this being the excessive accumulation of reactive oxygen
species, which include cancer, atherosclerosis, Parkinsons disease. This
research focuses on the study of the ligands PO, PC, L24 and their corresponding
copper complexes with potential biomimetic and antioxidant activity focused on
obtaining their redox potentials by cyclic voltammetry. These complexes have
the characteristic that their coordination geometry varies at different pH values,
and being in an alkaline environment their coordination geometry is similar to
the active site of the SOD and POx. We performed the electrochemistry
measurements of the ligands with Cu 2+ at pH values of 6.0 and 10.0 to evaluate
the redox behavior of the different coordination geometries by themselves and
to 7.4 to evaluate the behavior of the mixture of species. It was observed that
the complexes are capable of carrying out redox processes by the metal Cu (II) /
Cu (I) and Cu (I) / Cu (0) as well as in the organic fraction. For the complexes the
coordination mode that was most favorable in terms of the concentration of
redox products obtained is the square flat geometry (neutral to alkaline pH)
above the octahedral geometry (acid pH).
Keywords: Antioxidant, Complex, Macrocycles
Presenting authors email: elioalberto.molina@hotmail.com