Abstracts Book - IMRC 2018

• SB6-P004
MULTFUNCTIONAL NANOPLATAFORM COMPOSED OF
SUPERPARAMAGNETIC MANGANESE IRON OXIDE CORE AND A
MESOPOROUS SILICA SHELL FOR SIMULTANEUS DRUG DELIVERY
AND FLUORESCENCE IMAGING
Susel del Sol Fernandez 1 , Yosuan Avila García 1 , Herlys Viltres Cobas 1 , Ricardo García Salcedo 2 ,
Oscar Fernando Odio Chacón 1 , Eva Ramón Gallegos 3 , Edilso Reguera Ruiz 1
1 Centro de Investigación en Ciencia Aplicada y Tecnología Avanzada, Legaría, IPN, LNCAE,
Mexico. 2 Centro de Investigación en Ciencia Aplicada y Tecnología Avanzada, Legaría, IPN,
Física Educativa, Mexico. 3 Escuela Nacional de Ciencias Biológicas, Morfología, Mexico.
Manganese iron oxide nanoparticles (MnFe2O4) hold great promise for future
biomedical applications because of their magnetic and other intrinsic properties
such as low toxicity, colloidal stability, and surface engineering capability. There
has been growing interest in surface-engineered MnFe2O4 NPs with multiple
functionalities for various biomedical applications. Recently, multifunctional
nanostructured materials have been applied to multimodal imaging and
simultaneous diagnosis and therapy. In this context, the integration of
mesoporous silica with superparamagnetic monodisperse nanocrystals to form
uniform core–shell composite particles have great potential for simultaneous
bioimaging and drug delivery. In the present study, mixed ferrite (MnFe2O4) were
coated with a mesoporous silica and small dye molecules (Rhodamine 6G) were
incorporated in the silica framework imparted optical imaging modality. In
addition, anticancer drug was able to be loaded into the pores of mesoporous
silica nanoparticles for drug delivery. In the present study, (MnFe2O4) NPs were
coated with uniform mesoporous dye-doped silica. MnFe2O4@mSiO2-R6G
particles were characterized by DRX, TEM, HRTEM, STEM, FT-IR, PL spectroscopy,
VMS and N2 adsorption/desorption measurement. Results showed that a
spherical, highly-ordered MnFe2O4 nanoparticles with a diameter of around 10
nm, and a narrow size distribution. TEM and HRTEM image revealed that a
multicore MnFe2O4@mSiO2-R6G have a size of 70 nm. The field dependent
magnetism of at 300 K shows no hysteresis, demonstrating a
superparamagnetic behavior. The dye derivatized NPs (MnFe2O4@mSiO2(R6G)
dispersed in water showed the typical emissions of rhodamine 6B at 556 nm. N2
adsorption/desorption isotherms and the corresponding BJH pore size
distribution demonstrate that MnFe2O4@mSiO2 has well-developed 3.2. nm
mesopores; the BET surface area and the total pore volume were 481 and 1.07
cm 3 g _1 , respectively. The integrated capability of the core–shell NPs to be used