Abstracts Book - IMRC 2018

• SB2-P023
SYNTHESIS OF HOLLOW NANO-STRUCTURED HYDROXYAPATITE-
Au MICROSPHERES AND THEIR APPLICATION LIKE DRUG
DELIVERY SYSTEM
Gabriela Amor 1 , Ma. Fabiola León Galván 2 , Mónica Trejo 3 , Alejandro Vazquez 1 , Boris Kharisov 1
1 Universidad Autónoma de Nuevo León, Facultad de Ciencias Químicas, Mexico. 2 Universidad
de Guanajuato, Departamento de Alimentos, División de Ciencias de la Vida, Mexico.
3 Universidad de Guanajuato, Departamento de Estudios Multidisciplinarios, Mexico.
The world life expectancy has increased thanks to the scientific and technological
advances in medicine, more specifically in the field of the drug delivery. Oral and
transdermal delivery systems have evolved into smart delivery systems with the
ability to control the drug release time within the body as well as targeting the drug
dosage. In recent years nanoparticles and nanostructures have gained ground in
drug delivery systems because they possess unique physical, electrical, magnetic
and optical properties due to the effects of quantum mechanics in a nanometer
scale. Composites systems are attractive because they can take advantage of the
properties of each compound in a single material. Hydroxyapatite (HA) has excellent
biocompatibility and non-toxicity, as well as its good capacity of drug adsorption.
On the other hand, the Au nanorods possess practically no toxicity to the human
body due to their high stability, they also possess the property of Localized Surface
Plasmon Resonance (LSPR), which has made the Au a widely proposed material for
drug delivery and photothermal therapy. In this project, hollow CaCO 3
microspheres were synthesized by direct precipitation of Ca(NO 3 ) 2 with Na 2 CO 3
using SDS as a stabilizer. The HA was obtained with a similar hollow microsphere
structure by a transformation of CaCO 3 using Na 3 PO 4 solution via microwave; which
is a very attractive synthesis strategy because the morphology can be better
controlled in the synthesis of CaCO 3 than in the direct HA production. The synthesis
of Au nanorods was made by the typical seed-mediated growth method. The HA-Au
composites were obtained by an immersion method of the HA in a diluted solution
of Au nanorods. The materials were characterized by FTIR, XRD, UV-vis and SEM.
The hollow HA-Au microspheres were explored to study the drug loading and
release properties of doxorubicin (DOX), as a model drug, under absence and
presence of infrared radiation. The experimental results show that the HA-Au
material is promising for drug delivery and control dosage applications.
Keywords: Hydroxyapatite-Au, Hollow microspheres, Drug delivery system
Presenting authors email: gabyamor19994@gmail.com