Abstracts Book - IMRC 2018

• SB3-O005 Invited Talk
DEVELOPMENT OF HYDROGELS REINFORCED WITH
NANOHYDROXYAPATITE WITH INTEGRATION OF MAGNESIUM
AGAINST OSTEOPOROSIS
Gerardo Presbitero 1 , Laura Peña Parás 2 , Cristina Piña Barba 3 , Edgar Rodríguez 2 , Katya
Villarreal 2
1
Universidad Nacional Autónoma de México, Facultad de Ingeniería, Mexico. 2 Universidad de
Monterrey, Departamento de Ingeniería, Mexico. 3 Universidad Nacional Autónoma de México,
Instituto de Investigaciones en Materiales, Mexico.
The number of hip fractures due to osteoporosis in Mexican men and women
will increase to 226,886 cases by 2050, and worldwide could reach until 6.3
million. Additionally, magnesium deficiency in bone results in development of
osteoporosis and its use in the development of biomaterials has great
contribution towards the regeneration of tissues. Due to these reasons, it is
being developed sodium alginate and chitosan hydrogels reinforced with
nanohydroxyapatite, with integration of magnesium to facilitate the
acceleration of remodelling. Sodium alginate (SA) hydrogels reinforced with
halloysite nanotubes (HNT) and hydroxyapatite nanoparticles (HAP) were
prepared to improve the mechanical properties of this polymer. In the
preparation of the hydrogels, different concentrations of HNT and HAP
nanoparticles were used. Samples with different percentages of HAP content
were separated: control, SA with 20% HNT and HAP, SA with 40% HNT and HAP
and SA with 60% HNT and HAP. Up to this point, mechanical compression
characterization tests have been developed. The results showed an increase of
up to 2167.94% in the maximum compression resistance (UCS) and an increase
of 770.32% in Youngs modulus with the addition of these nanoparticles
compared to pure SA. Additionally, biocompatibility tests are carried out and
samples of SA with different concentrations of PAH content indicated above,
were analysed for characterization of porosity and architecture under
computerized microtomography (Micro-CT). These results indicated the amount
of HA particles changed significantly among the samples, accordingly with the
HA percentage used for their preparation. With the implementation of such
scaffolds we will be able to confirm it will be possible to provide the support and
filling required for the tissue affected by osteoporosis; while continuing with the
integration of magnesium will allow regeneration until the physiological
properties of the tissue have been recovered.