Abstracts Book - IMRC 2018

• SB6-O001 Invited Talk
SYNTHETIC SMALL CALIBER VASCULAR GRAFTS: CHEMISTRY,
MECHANICS AND BIOCOMPATIBILITY
Juan Valerio Cauich Rodriguez 1
1 Centro de Investigación Científica de Yucatán, Unidad de Materiales, Mexico.
Cardiovascular diseases are the main cause of worldwide death with 29% of total
global mortality. However, despite the increase in cardiovascular diseases, there
are very few substituent biomaterials for native artery, especially for small
diameter vascular grafts (SDVG) (< 6 mm). These SDVG frequently fail due to an
incompatibility between the native artery and the SDVG, and therefore, it is
commonly accepted that less than 50 % of the SDVG remain functional after 5
years. Taking this into consideration, a polyurethane based on HMDI-PCLarginine
(SPUR) was synthesized and blended with a commercial polyurethane
(Tecoflex) and their biocompatibility assesed. In addition, the mechanical
properties (longitudinal, circumferential tensile properties and pressure burst
strength) of these synthetic small vascular grafts was measured and these
properties compared with those of ovine and porcine arteries.
Blends of Tecoflex and SPUR tend to exhibit properties of pristine polymers as
shown by different analytical techniques. However, tensile mechanical
properties of films cannot be easily predicted by a rule of mixture.
Circumferential/longitudinal tensile and burst strength of grafts were above or
below of pristine polymers due to geometrical factors. Biocompatibility
definitively does not follow a simple rule of mixture.
Acknowledgment:
Consejo Nacional de Ciencia y Tecnologia through grants 248378 and 1360
Keywords: polyurethane, vascular graft, mechanical properties
Presenting authors email: jvcr@cicy.mx