Abstracts Book - IMRC 2018

• SB5-O015 Invited Talk
PROTEIN ADSORPTION AND CELLULAR RESPONSE TO
BIOCOMPATIBLE METAL OXIDE COATINGS
Phaedra Suriel Silva Bermudez 1 , Argelia Almaguer Flores 2 , Victor Irahuen García Pérez 2 , Rene
Olivares Navarrete 3 , Sandra Elizabeth Rodil 4
1
Instituto Nacional de Rehabilitacion, Unidad de Ingenieria de Tejidos, Terapia Celular y
Medicina Regenerativa, Mexico. 2 Universidad Nacional Autónoma de México, Division de
Investigación y Estudios de Posgrado, Facultad de Odontología, Mexico. 3 Virginia
Commonwealth University, Department of Biomedical Engineering, United States. 4 Universidad
Nacional Autónoma de México, Instituto de investigaciones en Materiales, Mexico.
Biomaterials with adequate properties to control the biological response and
meet biomechanical requirements are essential for orthopedic and dental
implants. It is well known that physicochemical surface properties of materials
direct their interactions with biological systems. Thus, coatings are interesting
options to tailor the surface properties of mechanically-adequate bulk materials
and, consequently, to functionalize their surfaces to modulate the biological
response. ZrO2 and TiO2, among other biocompatible metal oxides such as
Nb2O5 and Ta2O5, are of great interest as coatings for orthopedic and dental
implants, since it has been shown that they induce adequate oseointegration
processes and enhance mesenchymal stem cells differentiation to osteoblastic
phenotype. It is through a synergistic interaction of their specific surface
properties such as their morphology, wettability or roughness, that these metal
oxides induce specific biological responses. Moreover, changes in properties
such as atomic ordering, which consequently modify other surface properties
such as surface free energy (SFE) and nanotopography, modify the biological
response observed, even to the same surface chemistry. On the other hand, it
is also well known that the biological response to foreign materials is not a single
event but a complex cascade of events triggered upon contact of biological
systems with materials surfaces. Protein adsorption onto the material surface is
one of the first events to occur, leading to formation of an adsorbed protein
layer that mediates, or highly influence, cell-material interactions. In this study,
metal oxide thin films, mainly ZrO2 and TiO2, deposited by magnetron sputtering
on different substrates were used to study the correlations between surface
properties and protein adsorption and surface properties and cell response, in
order to gain a deeper understanding into the biological response to
biocompatible metal oxide coatings with potential applications as surface
functionalization techniques.