Abstracts Book - IMRC 2018

• SB5-O010 Invited Talk
RING-OPENING POLYMERIZATION OF EUTECTIC MIXTURES IN GEL
EMULSIONS: TOWARDS BIODEGRADABLE HIERARCHICAL
NANOCOMPOSITES FOR TISSUE ENGINEERING
Josue David Mota Morales 1 , María Guadalupe Pérez García 2 , Cristina Velasquillo Martínez 3 ,
Joseline Janai Hidalgo Moyle 1,3 , Jose Manuel Cervantes Díaz 2
1
Universidad Nacional Autónoma de México, Centro de Física Aplicada y Tecnología Avanzada,
Mexico. 2 Universidad de Guadalajara, Centro Universitario de Tonalá, Mexico. 3 Instituto
Nacional de Rehabilitacion, Biotecnología, Mexico.
HIPEs (high internal phase emulsions) or emulsions gel are highly viscous systems
in which the internal volume fraction accounts for more than 74% dispersed within
a minor continuous phase. The introduction of a polymerizable continuous phase
and subsequent extraction of the internal phase allows the synthesis of functional
architectures with unique hierarchical pore distributions. From the synthetic
viewpoint, poly(HIPEs) are very attractive materials because their morphologies and
mechanical properties can be modified by varying surfactant composition,
concentration of the external phase and polymerization conditions. In this talk the
use of HIPEs and eutectic mixtures able to undergo ring-opening polymerization
(ROP) will be introduced as a new approach to obtain biodegradable macroporous
polyesters (e.g. polycaprolactone and polylactide). The unique features of the
precursor monomers in the form of a eutectic mixture allow the ROP in such a way
that polymeric blends with tunable mechanical properties and morphologies are
obtained. Further, by taking advantage of the ability of the eutectic mixture to
disperse nano-objects, nanohydroxiapatite is advantageously used as co-surfactant
to enhance the stability of the HIPE. Upon ROP of the continuous phase of the
emulsion, the nanohydroxiapatite remains exposed functionalizing the inner walls
of the resulting polymeric scaffold. The presence of nanohydroxiapatite provides
another level of hierarchy to the scaffolds, which impacts the fate of the cells
cultured. Finally, biodegrabability profiles of the nanocomposites scaffolds and in
vitro biocompatibility tests using mesenchymal stem cells derived periostium will
be also presented.
Acknowledgment: This work was supported by the National Council of Science
and Technology (CONACYT), Mexico, through grants 252774, 261425 and
287405, PAPIIT-UNAM grant IA202018 and PRODEP grant UDG-PTC-1354.
Keywords: eutectic mixture, emulsion-templating, tissue engineering
Presenting authors email: mota_josue@hotmail.com