Abstracts Book - IMRC 2018

• SB6-P046
PRINTABLE HYDROGELS FOR PERIODONTAL REGENERATION
SYSTEM GELATIN-PVA REINFORCED WITH BIOCERAMICS
Wendy de Lourdes Ortega Lara 1
1 Tecnológico de Monterrey, Escuela de Ingenieria y Ciencias, Mexico.
Periodontitis represents a more advanced form of infection that is characterized
by inflammation, pocket formation, and bone resorption, with the subsequent
destruction of supporting periodontal tissues. One of the trends in regenerative
medicine is the use of new materials that have shown promotion of the healing
process and the formation of a new tissue. On the other hand, the selection of
bioactive ceramics (bone regeneration) and with antibacterial properties, both
very attractive properties during the regenerative process of the tissue.This
study focuses mainly on the development and design of hydrogels for soft tissue
regeneration. The Ag, TiO2, Na2Ti6O13 (sodium hexatitanate) and Ca3(PO4)2 or
tricalcium phosphate (TCP) reinforcement particles possess very interesting
characteristics, such as bioactivity and antibacterial properties. Several studies
were performed in the resulting hydrogel prototypes to have a better
understanding of their potential applications, including the following tests:
mechanical properties, fluids absorption ability, scanning electron microscope
(SEM) to verify the pore size was wide enough to store cells and the hydrogel
behavior while being extruded in a 3D printing machine. Some hydrated
hydrogels showed excellent mechanical properties and deformability. Scanning
electron microscopy images show a high porosity in all samples, especially in the
sample with TiO2 and TCP reinforcement (more than 100 MPa). SEM studies
showed pores large enough to accommodate chondrocytes are observed to
promote tissue regeneration. Further, in vitro analyses are been developing e in
order to confirm viability assays.
Keywords: hydrogel, 3D Printing, PVA-Gelatin
Presenting authors email: wlortega@itesm.mx