Abstracts Book - IMRC 2018

• SB6-P042
SYNTHESIS AND CHARACTERIZATION OF POLYMERIC
BIODEGRADABLE FILM FOR TREATMENT OF OPEN WOUND
Beatriz Martinez Perez 1,2 , Jorge Eduardo Munguía Huerta 2 , Juan Pablo Gutierrez López 2 , Alitzel
Belem García Hernández 2 , Abraham Orozco Bladorni 2 , Guadalupe Ugalde Guerrero 2
1 Facultad de Estudios Superiores Cuautitlán, UNAM., Laboratorio de Sistemas Farmacéuticos
de Liberación Modificada, Mexico. 2 Universidad Politécnica del Valle de México, División de
Ingeniería en Nanotecnología, Mexico.
INTRODUCTION: The utility of polymer biomaterials has become a very
interesting area for research, due to the large number of applications that are
attributed to them. A clear example of the multiple applications are the polymer
microfibers, which have been used in tissue engineering, biosensors,
pharmaceutical, electronic devices, filters and drug delivery (1). Polymeric,
uniaxial poly-ε-caprolactone, biocompatible and biodegradable polymer, and
triclosan were synthesized. Polymeric microfiber has diversity applications for
example to treatment of open wound. AIM: The objective of this research was
to obtain a prolonged delivery drug system of poly-Ô‘-caprolactone
loaded with triclosan as antiseptic film to treatment of open wound.
METHODOLOGY: Electrospinning device: The system was ensemble with
recycled pieces from televisions and printers. Synthesis of microfibers: 0.2g of
poly-Ô‘-caprolactone was dissolved with 0.25 g of triclosan in 3 mL of
acetone. The prepared solution was filled into a glass syringe and pushes it
down with a constant flow and a voltage of 10 kV. Microfibers were collected
from an aluminium sheet. Microbicidal activity was evaluated against
Staphylococcus aureus and Candida Albicans.
RESULTS: A polymeric film of triclosan was obtained. The mean diameter of
microfiber was of 4 µm. Microbicidal and antifungal activity was more efficient
than the triclosan-methanolic solution.
CONCLUSIONS: The electroespinning technique allowed us to synthesize a
polymeric film as an alternative for the treatment of open wounds.
REFERENCES:
1.- Agarwal, S., Wendorff, J. H., Greiner A. 2008. Use of electrospinning technique
for biomedical applications. Polymer. 49, 26(8).
Keywords: TRICLOSAN MICROFIBERS, OPEN WOUND FILM, BIOMEDICAL MATERIALS
Presenting authors email: betymp21@yahoo.com.mx