Abstracts Book - IMRC 2018

• SB6-P037
RADIATION-GRAFTING OF POLYPROPYLENE FILMS WITH METHYL
METHACRYLATE AND N-VINYLIMIDAZOLE: A VANCOMYCIN PH-
DEPENDENT RELEASE SYSTEM
F. López Saucedo 1 , G. G. Flores Rojas 1 , S. Gómez Dorantes 1 , E. Bucio 1
1 Instituto de Ciencias Nucleares UNAM, Quimica de Radiaciones y Macromoleculas, Mexico.
This research was addressed to design and modifiy polypropylene (PP) films
initiated by gamma-rays, bringing new features to the films for potential
applications in biomedical devices. The work involves the grafting onto PP films,
in the first step by pre-irradiation oxidative method with the monomer methyl
methacrylate (MMA), followed by the grafting of N-vinylimidazole (NVI) in the
second step by direct irradiation. The binary grafted film (PP-g-MMA)-g-NVI was
tested for vancomycin release at different pH and monitoring it by UV
spectrophotometry during 48 hours. The characterization included Fouriertransform
infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and
studies of physicochemical properties of swelling and contact angle. The main
findings of the (PP-g-MMA)-g-NVI perform a pH-dependent vancomycin release
rate
Acknowledgment:
This work was supported by DGAPA-UNAM under Grant IN201617. The authors
thank B. Leal ICN-UNAM for technical assistance.
Keywords: Gamma radiation, Vancomycin, Polypropylene film
Presenting authors email: ggabofo@hotmail.com