Abstracts Book - IMRC 2018

• SB3-P007
2D AND 3D NATURAL-BASED BIOMATERIALS FOR TISSUE
ENGINEERING
Eustolia Rodriguez Velazquez 1 , Remedios Sanchez Diaz 2 , Ana Gabriela Carrillo Varguez 1 , Miguel
Angel Cadena Alcantar 1 , Manuel Alatorre Meda 3
1
Universidad Autónoma de Baja California, Facultad de Odontologia-Tijuana, Mexico.
2 Universidad Autónoma de Baja California, ECISALUD, Mexico. 3 Instituto Tecnológico de
Tijuana, Centro de Graduados e Investigacion en Quimica, Mexico.
Tissue Engineering and Regenerative Medicine (TERM) are interdisciplinary
biomedical fields that integrate biology, engineering, materials science, and
medicine with the aim of developing biological substitutes to interact with living
cells in order to restore, replace, maintain, or enhance tissue and organ
functions. Most of the TERM strategies are based on the use of scaffolds that
are seeded with cells obtained the organ or tissue to be treated. The cells are
expanded in vitro within the scaffold up until they reach a certain level of
proliferation, and then the cell-laden scaffold is implanted in the patient at the
desired site of action. The cellular component is responsible for the generation
of the new tissue; meanwhile, the scaffold material provides a template to guide
the cellular growth and mechanical stability. Polysaccharides are excellent
materials for the synthesis of scaffolds. Among others, as extracted natural
sources, they are usually biocompatible and possess a significant ability to
absorb water. Moreover, they can be conveniently modified by chemical means
so as to display improved biological and physicochemical properties. The last
but not the least, they are abundant in the natural Extracellular Matrix (ECM)
and have a tremendous affinity for different endogenous
macromolecules. Herein, we present an overview of the most significant results
we have obtained in the last 5 years with respect to the synthesis and
characterization of polysaccharide-based 2D and 3D biomaterials for cell
seeding and encapsulation. Key features of the different systems such as the
chemical, superficial, mechanical, and biological characteristics are fully
discussed.
Acknowledgment:
Our work has been funded by CONACyT (Mexico) through the Research Projects
PDCPN-2015-89 and INFR-2015-251863; and by PRODEP (UABC) through Project
NPTC 2017-305/488/E.