Abstracts Book - IMRC 2018

• SB6-P069
SYNTHESIS AND CHARACTERIZATION OF POLYMERIC
NANOPOROUS MICROPARTICLES AS POTENCIAL DRUG
CARRIERS
Sayuri Chong 1 , Itzia I. Padilla Martínez 1 , Monica Corea 2
1 Instituto Politécnico Nacional - IPN, Laboratorio de Química Supramolecular y Nanociencias
UPIBI, Mexico. 2 Instituto Politécnico Nacional - IPN - ESIQIE, Laboratorio de Investigación en
Polímeros y Nanomateriales, Mexico.
Smart” hydrogels can undergo significant changes in their physicochemical
properties in response to a variety of environmental stimuli, such as
temperature, pH, electrical fields, and glucose. Hydrogels containing ionizable
groups can take advantage of their ability to volume changes depending on the
pH of the physiological medium 1 .
One of the ways to delay the therapeutic action of drugs are the functionalized
polymer nano- and micro-particles (NP’s or MP’s) 2 . In this work, nanoporous
MP’s were synthesized with acrylic acid functionalized methyl methacrylate and
crosslinked with ethylene glycol dimethylacrylate (PAA-PMA-EDGM) to achieve
functionalization levels of 20 and 25% and several degrees of cross-linking 0, 0.1,
0.3 and 0.5. MP’s were characterized by dynamic and static dispersion light, they
have a spherical shape and an average size of 300-450 nm at a pH 3 depending
on the functionalization and crosslinking degree. The hydrogels are pH-sensitive
they show pH-dependent swelling behavior. After freeze-drying MP’s showed
BET area in 10-12 m2g-1 range and a porous size of 6-8 nm, in the range of
mesoporous materials. The aim of this work is to develop new form of drug
delivery system for anticancer drugs.
1. Wu Wen, Wang Dong-shen. Reactive & Functional Polymers, 2010, 71, 684–
691.
2. Wan, J.; Geng, S.; Zhao, H.; Peng, X.; Zhou, Q.; Li, H.; He, M.; Zhao, Y.; Yang, X.;
Xun, H.; Journal of Controlled Release, 2016, ASAP article doi:
10.1016/j.jconrel.2016.06.009.
Keywords: nanoporous microparticles, pH-sensitive, freeze-drying
Presenting authors email: another_sayuri_2341@hotmail.com