Abstracts Book - IMRC 2018

• SB3-P004
A COMPARISON BETWEEN ELECTRO AND ROTARY-JET SPINNING
TO PRODUCE POLYMERIC FIBERS WITH INCORPORATED
NANOHYDROXYAPATITE AND CARBON NANOTUBES: REDUCED
BACTERICIDAL ACTIVITY
Mirian Michelle Machado de Paula 1,2 , Fernanda Roberta Marciano 3 , Marcus Alexandre Finzi
Corat 4 , Conceicao de Maria Vaz Elias 5 , Thomas Webster 1 , Anderson Lobo 3,6
1 Northeastern University, Department of Chemical Engineering, United States. 2 Universidade
do Vale do Paraiba, Laboratory of Biomedical Nanotechnology, Brazil. 3 Universidade Brasil,
Department of Biomedical Engineering, Brazil. 4 Universidade Estadual de Campinas,
Multidisciplinary Center for Biological Research, Brazil. 5 Universidade Brasil, Institute of Science
and Technology, Brazil. 6 Universidade Federal do Piauí, Materials Science Graduation Program,
Brazil.
Despite the progress tissue engineering has made in the development of
biomaterials, inhibiting bacterial infection has not been a central focus. Infection
is a leading cause of implant failures. Development of an implant capable of
reducing bacterial growth (without resorting to the use of antibiotics which
causes antibiotic resistant bacteria) would be an effective way to improve
implant success. Recently, surface modification of FDA approved polymers for
reduce bacterial growth has been gaining momentum. Carbon nanotubes and
hydroxyapatite have also been used to improve the mechanical, bioactivity and
bactericidal activity. However, there is not much research about their ability to
reduce bacteria adhesion when blended with polymers. In this study, electro
and rotary-jet spinning were used to produce nano/micro fibers with
incorporated nanoparticles. Herein, the efficacy of nano/micro fibers with
incorporated nanohydroxyapatite (nHAp) and carbon nanotubes (CNT) were
investigated in terms of their bactericidal properties. Polycaprolactone (PCL)
fibers raw or containing 1% of each CNT; nHAp; or CNT/nHAp (1:99) were
synthesized using electro and rotary jet spinning. SEM micrographs show that
the method used controlled composite morphology and roughness.
Comparatively, the rotary-jet spun nano/micro fibers were thickener and more
porous than those that by electrospun. Interesting, the rotary-jet spun fibers
with CNT, nHAp and CNT/nHAp presented ability to reduce bacteria adhesion
than those that were electrospun. In summary, this study provides significant
promise for the use of rotary jet spun PCL fibers for reducing implant infections
without resorting to the use of antibiotics for several tissue engineering
applications.