Abstracts Book - IMRC 2018

• SB2-P010
ENHANCED BIOLOGICAL COOLING WITH ENCAPSULATED PHASE
CHANGE NANOPARTICLES
Weike Hu 1
1 Northeastern University, Chemical Engineering, United States.
Controlling fever in animal is of importance as temperature plays key role in
determining biological functions. This article reports the use of encapsulated
phase change nanoparticles in the control of fever in animal model, where
paraffin with melting temperature of 37 °C is encapsulated in biocompatible
poly lactic-co-glycolic acid (PLGA). After injecting into mice with chemically
(lipopolysaccharide) induced fever, paraffin nanoparticles with large latent heat
of fusion melt and remove heat inside of the animal to the outside skin by
increasing heat capacity of blood. Encapsulation of nanoparticles avoids
agglomeration and possible reaction of molten nanoparticles, as well as surface
modification to reduce attachment on blood vessel. Temperature
responsiveness of phase change nanoparticles only allow melt until
temperature is sufficiently high, and do not solidify until temperature is
sufficiently low so that heat is deposited through skin to outside.
Acknowledgment:
This work has been supported by a National Institute of Health (NIH) grant
(1DP28016572)
Keywords: Encapsulated phase change nanoparticles, fever control, latent heat of
fusion
Presenting authors email: hu.wei@husky.neu.edu