Abstracts Book - IMRC 2018

• SB6-O004
DESORPTION STUDY OF IMMUNOSUPPRESSIVE,
ANTICOAGULANT AND ANTITHROMBOTIC DRUGS IN POLY (L-
LACTIC-CO-GLYCOLIC ACID) AND POLY (DL-LACTIC-CO-GLYCOLIC
ACID), FOR USE IN DRUG-ELUTING STENTS
María José Valarezo 1 , Lazaro Ruiz Virgen 1 , Rubén Caro Briones 1 , Francisco Rivera 1
1 Instituto Politécnico Nacional - IPN, ESIQIE, Mexico.
In this work, three types of poli(L-lactic-co-glycolic acid) (PLLGA) and poli(DLlactic-co-glycolic
acid) copolymers (PDLGA) with different lactide to glycolide
ratio (70:30, 80:20 and 90:10 %wtL-LA:%wtGA) were synthesized by means of
ring opening polymerization. The materials obtained were characterized by
known techniques to obtain composition, molecular weight distributions,
crystallinity and glass transition temperature. The degradation study of PLLGA
and PDLGA allows to follow molecular weight change, percentage of mass loss
and surface change of copolymers in presence of a saline solution. The results
showed that PLLGA and PDLGA copolymers degradation followed a first order
kinetic. PDLGA copolymers degraded faster than PLLGA copolymers, regardless
of lactide:glycolide ratio. Sodic heparine an antitrombotic, acetylsalicylic acid an
anti-inflammatory drug and prednisone an inmunosupresed drug was
incorporated to the polymer matrices and its release process was quantified by
UV-vis spectroscopy. In the assay it was analyzed the concentration change in
the saline solution. The release of the three drugs was controlled by both drug
diffusion and polymer degradation. In addition, it could be notice that
acetylsalicylic acid causes an unusually faster degradation of PLLGA and PDLGA.
Finally drugs released kinetic was adjusted to two model proposed for
biodegradable systems: Higuchis and Charlie.
Acknowledgment:
Instituto Politécnico Nacional, Escuela Superior de Ingeniería Química e
Industrias Extractivas ESIQIE, Consejo Nacional de Ciencia y Tecnologia
CONACyt
Keywords: PLGA, stent, drug desorption
Presenting authors email: marijoe_88@hotmail.com