Abstracts Book - IMRC 2018

• SB6-P054
PLLGA COPOLYMERS: A DEGRADATION, DRUG DESORPTION AND
CYTOTOXICITY STUDY
María José Valarezo 1,2 , Lazaro Ruiz Virgen 3 , Rubén Caro Briones 3 , Francisco Rivera Rojas 3
1 Instituto Politécnico Nacional - IPN, Escuela Superior de Ingeniería Química e Industrias
Extractivas, Mexico. 2 Instituto Politécnico Nacional - IPN, ESIQIE-POLÍMEROS, Mexico. 3 Instituto
Politécnico Nacional - IPN, ESIQIE, Mexico.
The aims of the present work, were to study the poli(L-lactic-co glycolic)
copolymers (PLLGA) degradation process, prednisone drug desorption and
PLLGA degradation products cytotoxicity. For these reason three combinations
of (PLLGA) with different lactide to glycolide ratio (70:30, 80:20 and 90:10 %wtL-
LA:%wtGA ) were synthesized by means of ring opening polymerization. The
materials obtained were characterized in order to know their structure, chemical
composition, molecular weight and glass transition temperature. The
degradation and drug desorption studies were realized in vitro during 336h at
37°C in saline solution. For degradation study change in molecular weight, mass
loss and optical microscopy images were taken into account, and for prednisone
desorption UV spectroscopy at 240nm was used. The results showed that PLLGA
degradation followed a first order kinetic and prednisone released was
government by two phenomena diffusion and degradation. For these reason
the drug desorption kinetic was adjusted to two model proposed for
biodegradable systems: Higuchis and Charlie. Drug diffusion coefficients were
higher in copolymers with higher percentage of glycolic acid, and they were
increasing, as the degradation process was progressing. The cytotoxicity assay
evidenced that PLLGA copolymers and PLLGA degradation products were not
toxic in endothelial cells.
Acknowledgment:
Acknowledgment to: Instituto Politécnico Nacional, Escuela Superior de
Ingeniería Química e Industrias Extractivas ESIQIE and Consejo Nacional de
Ciencia y Tecnologia CONACyT
Keywords: PLLGA, Drug desorption, Cytotoxicity
Presenting authors email: marijoe_88@hotmail.com