Abstracts Book - IMRC 2018

• SWMC-O032 Invited Talk
EVALUATION OF A PEPTIDE-MEDIATED STRATEGY FOR ESCAPING
THE CAPYURE OF NANOPARTICLES BY IMMUNO SYSTEM
Chunlan Liu 1 , Danxia Yu 1 , Limin Yang 1 , Qiuquan Wang 1
1 Xiamen University, Department of Chemistry, China.
When nanomaterials as carriers are used for drug delivery, they cannot escape
the capture of innate immuno system (mononuclear phagocyte system) that
resides in the organs like liver and spleen. It was reported that only less than 1
% nanoscale drug delivery devices could reach the targeted cells, greatly
reducing the efficacy of drugs or other physical treatments. We know that
overexpress of CD47 on the surface of cancer cells, and the interaction between
CD47 and signal regulatory protein alpha (SIRPa) on the phagocyte makes
cancer cells avoiding the capture of macrophages. We recently used the
functional peptide sequence of CD47 to modify SiO 2 nanoparticles (nSiO 2 -
peptide) to see whether nSiO 2 -peptide can be “eaten” or not by the
macrophages RAW264.7. Results CLSM and ICP-MS studies indicated that the
macrophages did not eat nSiO 2 -peptide until 2 hours, while the macrophages
started to devour the nSiO 2 without peptide modification at the very beginning
point of incubation. Such a strategy provide a way to improve drug delivery
efficiency, and thus efficacy of drugs and other later physical treatments.
Acknowledgment:
We thank the financial support from the National Basic Research 973 Program
(Grant 2014CB932004) and the National Natural Science Foundation of China
(Grants 21535007, 21475108) as well as National Science and Technology Basic
Work (2015FY111400).
Keywords: Nanoparticle, Surface modification, Immuno system
Presenting authors email: qqwang@xmu.edu.cn