Abstracts Book - IMRC 2018

• SB6-P067
STUDY OF NIOSOMAS THERMAL STABILITY
María Fernanda Bautista Pérez 1 , Juan Ramón Avendaño Gómez 1 , Obed Andres Solis Gonzalez 1 ,
Citlali Uitz T. 1
1 Instituto Politécnico Nacional - IPN - ESIQIE, Ingeniería Química, Mexico.
In the past few years the use of liposomes and niosomes in encapsulation
systems has become a trending research topic. Niosomes are preferred as
medicine administering system over the liposomes, they are mainly composed
by non-ionic tensoactives, which after being hydrated form nanoscopic lamellar
vesicles. Non-ionic tensoactives are widely used due to their properties and the
capacity to carry out stable formulations, also, they are suitable for the
aggregation of an additive that can reinforce the vesicle.
The present work has as objectives to determine the proper formulation in order
to obtain Niosomes using Tween 20 as tensoactive agent, with the aggregation
of Pluronic (F-108, F-127, F-123) as additive, using the stirring method. A
physicochemical and morphological characterization is to be carried out.
The vesicle was obtained with the stirring method using an aqueous 14 mM
solution of Tween 20, the mixture was stirred during 24 h until and homogenous
solution was obtained, afterwards, the solution was sonicated during 1 h at 40
kHz.
Dynamic Light Scattering (DLS) was used in order to measure the diameter and
the critic micellar concentration (CMC), a polydispersion within 10 and 100 nm
was obtained, as well as a CMC of 0,09 mmol/L at 25 °C.
Several techniques such as Transition Electron Microscopy (TEM) and Scanning
Electron Microscopy(SEM) are to be used for the morphological characterization.
Differential Scanning Calorimetry (DSC) will be used to measure the heat
produced when a phase change occurs. Niosomes characterization is set as a
main and interesting objective in this work.
Keywords: Nanoparticules, Niosomes, Non-ionic surfactants
Presenting authors email: mafer_bp@hotmail.com