Abstracts Book - IMRC 2018

• SB6-O031
POLYMER DECORATED PLASMONIC COPPER NANOPARTICLES AS
NANOARMADAS: A COMBINATORIAL CANCER THERAPEUTIC
APPROACH
Goldie Oza 1 , Almendra Reyes 2 , Karen Analy Chavez Bracamont 2 , Mauricio Alberto Medina
Pérez 3 , Ashutosh Sharma 2 , Walter Noe Velazquez Arjona 1 , Luis Gerardo Arriaga Hurtado 1 , Jose
Tapia Ramirez 4
1 Centro de Investigación y Desarrollo Tecnológico en Electroquímica, Laboratorio Nacional de
Micro y Nanofluidics, Mexico. 2 Tecnológico de Monterrey, Departamento de Bioingenieria,
Mexico. 3 Centro de Investigación y de Estudios Avanzados del IPN - CINVESTAV, Nanoscience
and Nanotechnology, Mexico. 4 Centro de Investigación y de Estudios Avanzados del IPN -
CINVESTAV, Genetica y Biologia Molecular, Mexico.
There are plethora of polymers such as PLGA, PLA, High density lipoprotein (HDL)
that are being explored for Cancer therapeutics. Copper nanoparticles have been
emerging as an efficient scaffold for both drug-deliveries as well as for decoration
of ligands such as HDL, thus mimicking biological vesicles transporting metal
complexes. In this reported work, we emphasize specifically on tethering copper
nanoparticles with Doxorubicin since they efficiently kill cancer cells. Moreover
cancer cells undergo aberrant cell proliferation and cholesterol is a known complex
playing an important role in cancer cell progression. Hence, HDL has been used for
assembling on the surface of copper nanoparticles which are already tethered to
anti-cancer drugs. Such HDL nanostructured assembly are known to either target
receptor- mediated endocytic holoparticle or scavenger receptors of the B-class.
Further to make the complex more synaphic, folate are attached on HDL
nanostructured assembly, so that the uptake is further augmented. The mechanism
involves selective uptake of HDL-cholesteryl esters - copper nanoparticle- anticancer
drug complex and then there is subsequent degradation of cholesteryl
esters in an extralysosomal compartment which can be mediated by hormonesensitive
lipase. In comparison to natural HDLs, such biomimicked HDL competes
with the receptors, thus making cells to be deficient of cholesterol, leading to
cellular cholesterol efflux and limited cholesterol delivery. Further, Doxorubicin can
be used to kill cancer cells by binding DNA gyrases. This combinatorial approach of
anticancer drug delivery as well as cholesterol starvation selectively induces
apoptosis and is an efficient modus operandi for Cancer Therapeutics.
Keywords: Polymer, Copper nanoparticles, Doxorubicin
Presenting authors email: goldieoza@gmail.com